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@article{Wolf:2021:10.1002/uog.23615,
author = {Wolf, H and Stampalija, T and Lees, CC and Arabin, B and Berger, A and Bergman, E and Bhide, A and Bilardo, CM and Breeze, AC and Brodszki, J and Calda, P and Cesari, E and Cetin, I and Derks, J and Ebbing, C and Ferrazzi, E and Frusca, T and Ganzevoort, W and Gordijn, SJ and Gyselaers, W and Hecher, K and Klaritsch, P and Krofta, L and Lindgren, P and Lobmaier, SM and Marlow, N and Maruotti, GM and Mecacci, F and Myklestad, K and Napolitano, R and Prefumo, F and Raio, L and Richter, J and Sande, RK and Thornton, J and Valensise, H and Visser, GHA and Wee, L},
doi = {10.1002/uog.23615},
journal = {Ultrasound in Obstetrics and Gynecology},
pages = {705--715},
title = {Fetal cerebral blood-flow redistribution: analysis of Doppler reference charts and association of different thresholds with adverse perinatal outcome},
url = {http://dx.doi.org/10.1002/uog.23615},
volume = {58},
year = {2021}
}

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TY  - JOUR
AB  - ObjectivesFirst, to compare published Doppler reference charts of the ratios of flow in the fetal middle cerebral and umbilical arteries (i.e. the cerebroplacental ratio (CPR) and umbilicocerebral ratio (UCR)). Second, to assess the association of thresholds of CPR and UCR based on these charts with short-term composite adverse perinatal outcome in a cohort of pregnancies considered to be at risk of late preterm fetal growth restriction.MethodsStudies presenting reference charts for CPR or UCR were searched for in PubMed. Formulae for plotting the median and the 10th percentile (for CPR) or the 90th percentile (for UCR) against gestational age were extracted from the publication or calculated from the published tables. Data from a prospective European multicenter observational cohort study of singleton pregnancies at risk of fetal growth restriction at 32 + 0 to 36 + 6 weeks' gestation, in which fetal arterial Doppler measurements were collected longitudinally, were used to compare the different charts. Specifically, the association of UCR and CPR thresholds (CPR < 10th percentile or UCR ≥ 90th percentile and multiples of the median (MoM) values) with composite adverse perinatal outcome was analyzed. The association was also compared between chart-based thresholds and absolute thresholds. Composite adverse perinatal outcome comprised both abnormal condition at birth and major neonatal morbidity.ResultsTen studies presenting reference charts for CPR or UCR were retrieved. There were large differences between the charts in the 10th and 90th percentile values of CPR and UCR, respectively, while median values were more similar. In the gestational-age range of 28–36 weeks, there was no relationship between UCR or CPR and gestational age. From the prospective observational study, 856 pregnancies at risk of late-onset preterm fetal growth restriction were included in the analysis. The association of abnorm
AU  - Wolf,H
AU  - Stampalija,T
AU  - Lees,CC
AU  - Arabin,B
AU  - Berger,A
AU  - Bergman,E
AU  - Bhide,A
AU  - Bilardo,CM
AU  - Breeze,AC
AU  - Brodszki,J
AU  - Calda,P
AU  - Cesari,E
AU  - Cetin,I
AU  - Derks,J
AU  - Ebbing,C
AU  - Ferrazzi,E
AU  - Frusca,T
AU  - Ganzevoort,W
AU  - Gordijn,SJ
AU  - Gyselaers,W
AU  - Hecher,K
AU  - Klaritsch,P
AU  - Krofta,L
AU  - Lindgren,P
AU  - Lobmaier,SM
AU  - Marlow,N
AU  - Maruotti,GM
AU  - Mecacci,F
AU  - Myklestad,K
AU  - Napolitano,R
AU  - Prefumo,F
AU  - Raio,L
AU  - Richter,J
AU  - Sande,RK
AU  - Thornton,J
AU  - Valensise,H
AU  - Visser,GHA
AU  - Wee,L
DO  - 10.1002/uog.23615
EP  - 715
PY  - 2021///
SN  - 0960-7692
SP  - 705
TI  - Fetal cerebral blood-flow redistribution: analysis of Doppler reference charts and association of different thresholds with adverse perinatal outcome
T2  - Ultrasound in Obstetrics and Gynecology
UR  - http://dx.doi.org/10.1002/uog.23615
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000713324900007&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://obgyn.onlinelibrary.wiley.com/doi/10.1002/uog.23615
UR  - http://hdl.handle.net/10044/1/93847
VL  - 58
ER  -

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