Imperial College London
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Professor Christoph Lees, MD FRCOG

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Professor of Obstetrics
 
 
 
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Contact

 

+44 (0)20 7594 5770c.lees

 
 
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Assistant

 

Ms Hazel Blackman +44 (0)20 7594 2104

 
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Location

 

Queen Charlottes and Chelsea HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Kyriacou:2021:10.1002/ajum.12247,
author = {Kyriacou, C and Roper, L and Mappouridou, S and Lees, C and Prior, T},
doi = {10.1002/ajum.12247},
journal = {Australasian Journal of Ultrasound Medicine},
pages = {137--142},
title = {Contemporary experience of polyhydramnios: a single-centre experience},
url = {http://dx.doi.org/10.1002/ajum.12247},
volume = {24},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Introduction: Polyhydramnios is common; the majority of cases are idiopathic, but maybe associated with fetal abnormality. Literature suggests the volume of amniotic fluid discriminates idiopathic from pathological polyhydramnios but is not unanimous. We assessed fetal anomaly incidence amongst women with polyhydramnios and the role of discriminatory variables in identifying pathological cases. Methods: Retrospective observational cohort study at an inner-city London fetal medicine centre. Records for patients referred and/or diagnosed with polyhydramnios were reviewed as well as maternal/fetal demographics, amongst singleton pregnancies using the Astraia™ database from January 2015-2016. Estimated fetal weight was calculated using the Hadlock model (biometry undertaken at diagnosis). Student's t-test/one-way ANOVA compared means; chi-squared tests compared proportions. Results: 120 cases were identified. 36 (30%) had fetal abnormality. There was no difference in AFI between fetuses with an abnormality and without (26.7 vs 25.2 cm, P = 0.22). AFI was normalised for weight (AFI (cm)/estimated fetal weight (kg)): AFI/kg was significantly different between cases with fetal abnormality and without (24.4 vs 16.7 cm/kg, P < 0.001) - incidence of abnormality increased with increasing AFI/kg (P = 0.007). Early gestational diagnosis was associated with higher rates of anomaly (P = 0.004). Differences in AFI/kg between those with and without abnormality were not significant when adjusted for gestation. AFI was significantly higher in cases of abnormality diagnosed at later gestation (P = 0.005). Conclusion: Excess volume of amniotic fluid alone does not denote abnormality. Earlier gestations and higher AFI/kg corresponded with significantly increased rates of anomaly. However, the latter is a result of confounding by gestation, which is closely correlated with fetal weight.
AU  - Kyriacou,C
AU  - Roper,L
AU  - Mappouridou,S
AU  - Lees,C
AU  - Prior,T
DO  - 10.1002/ajum.12247
EP  - 142
PY  - 2021///
SN  - 1441-6891
SP  - 137
TI  - Contemporary experience of polyhydramnios: a single-centre experience
T2  - Australasian Journal of Ultrasound Medicine
UR  - http://dx.doi.org/10.1002/ajum.12247
UR  - https://www.ncbi.nlm.nih.gov/pubmed/34765423
UR  - http://hdl.handle.net/10044/1/93416
VL  - 24
ER  -
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