Publications

BibTex format

@article{Mylrea-Foley:2022:10.1136/bmjopen-2021-055543,
author = {Mylrea-Foley, B and Thornton, JG and Mullins, E and Marlow, N and Hecher, K and Ammari, C and Arabin, B and Berger, A and Bergman, E and Bhide, A and Bilardo, C and Binder, J and Breeze, A and Brodszki, J and Calda, P and Cannings-John, R and Cerny, A and Cesari, E and Cetin, I and Dall'Asta, A and Diemert, A and Ebbing, C and Eggebo, T and Fantasia, I and Ferrazzi, E and Frusca, T and Ghi, T and Goodier, J and Greimel, P and Gyselaers, W and Hassan, W and Von, Kaisenberg C and Kholin, A and Klaritsch, P and Krofta, L and Lindgren, P and Lobmaier, S and Marsal, K and Maruotti, GM and Mecacci, F and Myklestad, K and Napolitano, R and Ostermayer, E and Papageorghiou, A and Potter, C and Prefumo, F and Raio, L and Richter, J and Sande, RK and Schlembach, D and Schleussner, E and Stampalija, T and Thilaganathan, B and Townson, J and Valensise, H and Ha, Visser G and Wee, L and Wolf, H and Lees, CC},
doi = {10.1136/bmjopen-2021-055543},
journal = {BMJ Open},
pages = {1--8},
title = {Perinatal and 2-year neurodevelopmental outcome in late preterm fetal compromise: the TRUFFLE 2 randomised trial protocol},
url = {http://dx.doi.org/10.1136/bmjopen-2021-055543},
volume = {12},
year = {2022}
}

Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Introduction Following the detection of fetal growth restriction, there is no consensus about the criteria that should trigger delivery in the late preterm period. The consequences of inappropriate early or late delivery are potentially important yet practice varies widely around the world, with abnormal findings from fetal heart rate monitoring invariably leading to delivery. Indices derived from fetal cerebral Doppler examination may guide such decisions although there are few studies in this area. We propose a randomised, controlled trial to establish the optimum method of timing delivery between 32 weeks and 36 weeks 6 days of gestation. We hypothesise that delivery on evidence of cerebral blood flow redistribution reduces a composite of perinatal poor outcome, death and short-term hypoxia-related morbidity, with no worsening of neurodevelopmental outcome at 2 years.Methods and analysis Women with non-anomalous singleton pregnancies 32+0 to 36+6 weeks of gestation in whom the estimated fetal weight or abdominal circumference is <10th percentile or has decreased by 50 percentiles since 18–32 weeks will be included for observational data collection. Participants will be randomised if cerebral blood flow redistribution is identified, based on umbilical to middle cerebral artery pulsatility index ratio values. Computerised cardiotocography (cCTG) must show normal fetal heart rate short term variation (≥4.5 msec) and absence of decelerations at randomisation. Randomisation will be 1:1 to immediate delivery or delayed delivery (based on cCTG abnormalities or other worsening fetal condition). The primary outcome is poor condition at birth and/or fetal or neonatal death and/or major neonatal morbidity, the secondary non-inferiority outcome is 2-year infant general health and neurodevelopmental outcome based on the Parent Report of Children’s Abilities-Revised questionnaire.Ethics and dissemination The Study Coordination Centre has obtaine
AU  - Mylrea-Foley,B
AU  - Thornton,JG
AU  - Mullins,E
AU  - Marlow,N
AU  - Hecher,K
AU  - Ammari,C
AU  - Arabin,B
AU  - Berger,A
AU  - Bergman,E
AU  - Bhide,A
AU  - Bilardo,C
AU  - Binder,J
AU  - Breeze,A
AU  - Brodszki,J
AU  - Calda,P
AU  - Cannings-John,R
AU  - Cerny,A
AU  - Cesari,E
AU  - Cetin,I
AU  - Dall'Asta,A
AU  - Diemert,A
AU  - Ebbing,C
AU  - Eggebo,T
AU  - Fantasia,I
AU  - Ferrazzi,E
AU  - Frusca,T
AU  - Ghi,T
AU  - Goodier,J
AU  - Greimel,P
AU  - Gyselaers,W
AU  - Hassan,W
AU  - Von,Kaisenberg C
AU  - Kholin,A
AU  - Klaritsch,P
AU  - Krofta,L
AU  - Lindgren,P
AU  - Lobmaier,S
AU  - Marsal,K
AU  - Maruotti,GM
AU  - Mecacci,F
AU  - Myklestad,K
AU  - Napolitano,R
AU  - Ostermayer,E
AU  - Papageorghiou,A
AU  - Potter,C
AU  - Prefumo,F
AU  - Raio,L
AU  - Richter,J
AU  - Sande,RK
AU  - Schlembach,D
AU  - Schleussner,E
AU  - Stampalija,T
AU  - Thilaganathan,B
AU  - Townson,J
AU  - Valensise,H
AU  - Ha,Visser G
AU  - Wee,L
AU  - Wolf,H
AU  - Lees,CC
DO  - 10.1136/bmjopen-2021-055543
EP  - 8
PY  - 2022///
SN  - 2044-6055
SP  - 1
TI  - Perinatal and 2-year neurodevelopmental outcome in late preterm fetal compromise: the TRUFFLE 2 randomised trial protocol
T2  - BMJ Open
UR  - http://dx.doi.org/10.1136/bmjopen-2021-055543
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000783842400035&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://bmjopen.bmj.com/content/12/4/e055543
UR  - http://hdl.handle.net/10044/1/92857
VL  - 12
ER  -

Download

Professor Christoph Lees, MD FRCOG

Contact

Assistant

Location

Summary

Citation

BibTex format

RIS format (EndNote, RefMan)