Imperial College London
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Professor Christoph Lees, MD FRCOG

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Professor of Obstetrics
 
 
 
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Contact

 

+44 (0)20 7594 5770c.lees

 
 
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Assistant

 

Ms Hazel Blackman +44 (0)20 7594 2104

 
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Location

 

Queen Charlottes and Chelsea HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Jaspal:2022:10.1007/s44200-022-00019-9,
author = {Jaspal, R and Allen, M and Cornette, J and Rizopoulos, D and Lees, C},
doi = {10.1007/s44200-022-00019-9},
journal = {Artery Research},
pages = {100--104},
title = {Validation of non-invasive measurements of cardiac output: using whole body bio-impedance versus inert gas rebreathing in healthy women undergoing in vitro fertilisation},
url = {http://dx.doi.org/10.1007/s44200-022-00019-9},
volume = {28},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background:Haemodynamic assessment in and before pregnancy is becoming increasingly important in relation to pregnancy complications and outcomes. Different methodologies exist but there is no gold-standard technique for non-invasive measurement of cardiac output (CO). We sought to assess two methods of CO measurement in healthy women undergoing In Vitro Fertilisation Cycles (IVF). This was a prospective longitudinal study of 71 women aged 18-44yrs planning IVF undergoing CO measurements obtained via Inert Gas rebreathing (IGR) using InnocorTM and whole-body bio-impedance (WBI) using NicasTM in order to assess the reproducibility between the methods.  Four visits occurred at which both techniques were used: initial assessment,  embryo transfer, day of pregnancy test and 4 weeks post transfer (regardless of whether conception occurred).Cross-sectional agreement of the methods was assessed using the calculation of bias, percentage error and Limits of Agreement (LOA) via the Bland-Altman analysis. Longitudinal agreement of the methods was assessed using a 4-quadrant plot with concordance rate, angular bias and radial limits of agreement (%).Results:113 measurements from 44 participants were suitable for cross-sectional (Bland-Altman) analysis. IGR (InnocorTM) Mean CO was 4.61 L/min and 5.05 L/min with WBI (NicasTM). The bias was 0.44L/min. The percentage error was 76% and intra-correlation coefficient was 0.135 (95%CI -0.43 – 0.306).59 measurements from 28 participants were suitable for longitudinal (4Q-plot) analysis. The concordance rate was 64.4 %, angular bias -0.14, radial limits of agreement +- 13.25°.Conclusions:There was poor cross-sectional and longitudinal agreement between inert gas rebreathing and whole-body bio- impedance techniques. These techniques cannot be used interchangeably when measuring CO in women undergoing IVF, and these results may be more generalizable.
AU  - Jaspal,R
AU  - Allen,M
AU  - Cornette,J
AU  - Rizopoulos,D
AU  - Lees,C
DO  - 10.1007/s44200-022-00019-9
EP  - 104
PY  - 2022///
SN  - 1872-9312
SP  - 100
TI  - Validation of non-invasive measurements of cardiac output: using whole body bio-impedance versus inert gas rebreathing in healthy women undergoing in vitro fertilisation
T2  - Artery Research
UR  - http://dx.doi.org/10.1007/s44200-022-00019-9
UR  - http://hdl.handle.net/10044/1/98290
VL  - 28
ER  -
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