Imperial College London
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Professor Christoph Lees, MD FRCOG

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Professor of Obstetrics
 
 
 
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Contact

 

+44 (0)20 7594 5770c.lees

 
 
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Assistant

 

Ms Hazel Blackman +44 (0)20 7594 2104

 
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Location

 

Queen Charlottes and Chelsea HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Mullins:2022:10.1016/j.ejogrb.2022.07.010,
author = {Mullins, E and Perry, A and Banerjee, J and Townson, J and Grozeva, D and Milton, R and Kirby, N and Playle, R and Bourne, T and Lees, C and PAN-COVID, Investigators},
doi = {10.1016/j.ejogrb.2022.07.010},
journal = {European Journal of Obstetrics Gynecology and Reproductive Biology},
pages = {161--167},
title = {Pregnancy and neonatal outcomes of COVID-19: The PAN-COVID study.},
url = {http://dx.doi.org/10.1016/j.ejogrb.2022.07.010},
volume = {276},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - OBJECTIVE: To assess perinatal outcomes for pregnancies affected by suspected or confirmed SARS-CoV-2 infection. METHODS: Prospective, web-based registry. Pregnant women were invited to participate if they had suspected or confirmed SARS-CoV-2 infection between 1st January 2020 and 31st March 2021 to assess the impact of infection on maternal and perinatal outcomes including miscarriage, stillbirth, fetal growth restriction, pre-term birth and transmission to the infant. RESULTS: Between April 2020 and March 2021, the study recruited 8239 participants who had suspected or confirmed SARs-CoV-2 infection episodes in pregnancy between January 2020 and March 2021. Maternal death affected 14/8197 (0.2%) participants, 176/8187 (2.2%) of participants required ventilatory support. Pre-eclampsia affected 389/8189 (4.8%) participants, eclampsia was reported in 40/ 8024 (0.5%) of all participants. Stillbirth affected 35/8187 (0.4 %) participants. In participants delivering within 2 weeks of delivery 21/2686 (0.8 %) were affected by stillbirth compared with 8/4596 (0.2 %) delivering ≥ 2 weeks after infection (95 % CI 0.3-1.0). SGA affected 744/7696 (9.3 %) of livebirths, FGR affected 360/8175 (4.4 %) of all pregnancies. Pre-term birth occurred in 922/8066 (11.5%), the majority of these were indicated pre-term births, 220/7987 (2.8%) participants experienced spontaneous pre-term births. Early neonatal deaths affected 11/8050 livebirths. Of all neonates, 80/7993 (1.0%) tested positive for SARS-CoV-2. CONCLUSIONS: Infection was associated with indicated pre-term birth, most commonly for fetal compromise. The overall proportions of women affected by SGA and FGR were not higher than expected, however there was the proportion affected by stillbirth in participants delivering within 2 weeks of infection was significantly higher than those delivering ≥ 2 weeks after infection. We suggest that clinicians' thresh
AU  - Mullins,E
AU  - Perry,A
AU  - Banerjee,J
AU  - Townson,J
AU  - Grozeva,D
AU  - Milton,R
AU  - Kirby,N
AU  - Playle,R
AU  - Bourne,T
AU  - Lees,C
AU  - PAN-COVID,Investigators
DO  - 10.1016/j.ejogrb.2022.07.010
EP  - 167
PY  - 2022///
SN  - 0301-2115
SP  - 161
TI  - Pregnancy and neonatal outcomes of COVID-19: The PAN-COVID study.
T2  - European Journal of Obstetrics Gynecology and Reproductive Biology
UR  - http://dx.doi.org/10.1016/j.ejogrb.2022.07.010
UR  - https://www.ncbi.nlm.nih.gov/pubmed/35914420
UR  - https://www.sciencedirect.com/science/article/pii/S0301211522004328?via%3Dihub
UR  - http://hdl.handle.net/10044/1/98959
VL  - 276
ER  -
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