Imperial College London
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Professor Christoph Lees, MD FRCOG

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Professor of Obstetrics
 
 
 
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Contact

 

+44 (0)20 7594 5770c.lees

 
 
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Assistant

 

Ms Hazel Blackman +44 (0)20 7594 2104

 
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Location

 

Queen Charlottes and Chelsea HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Smith:2023:10.1136/bmjgh-2022-009495,
author = {Smith, ER and Oakley, E and Grandner, GW and Ferguson, K and Farooq, F and Afshar, Y and Ahlberg, M and Ahmadzia, H and Akelo, V and Aldrovandi, G and Barr, BAT and Bevilacqua, E and Brandt, JS and Broutet, N and Buhigas, IF and Carrillo, J and Clifton, R and Conry, J and Cosmi, E and Crispi, F and Crovetto, F and Delgado-Lopez, C and Divakar, H and Driscoll, AJ and Favre, G and Flaherman, VJ and Gale, C and Gil, MM and Gottlieb, SL and Gratacos, E and Hernandez, O and Jones, S and Kalafat, E and Khagayi, S and Knight, M and Kotloff, K and Lanzone, A and Le, Doare K and Lees, C and Litman, E and Lokken, EM and Laurita, Longo V and Madhi, SA and Magee, LA and Martinez-Portilla, RJ and McClure, EM and Metz, TD and Miller, ES and Money, D and Moungmaithong, S and Mullins, E and Nachega, JB and Nunes, MC and Onyango, D and Panchaud, A and Poon, LC and Raiten, D and Regan, L and Rukundo, G and Sahota, D and Sakowicz, A and Sanin-Blair, J and Soderling, J and Stephansson, O and Temmerman, M },
doi = {10.1136/bmjgh-2022-009495},
journal = {BMJ Global Health},
pages = {1--19},
title = {Adverse maternal, fetal, and newborn outcomes among pregnant women with SARS-CoV-2 infection: an individual participant data meta-analysis},
url = {http://dx.doi.org/10.1136/bmjgh-2022-009495},
volume = {8},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Introduction Despite a growing body of research on the risks of SARS-CoV-2 infection during pregnancy, there is continued controversy given heterogeneity in the quality and design of published studies.Methods We screened ongoing studies in our sequential, prospective meta-analysis. We pooled individual participant data to estimate the absolute and relative risk (RR) of adverse outcomes among pregnant women with SARS-CoV-2 infection, compared with confirmed negative pregnancies. We evaluated the risk of bias using a modified Newcastle-Ottawa Scale.Results We screened 137 studies and included 12 studies in 12 countries involving 13 136 pregnant women.Pregnant women with SARS-CoV-2 infection—as compared with uninfected pregnant women—were at significantly increased risk of maternal mortality (10 studies; n=1490; RR 7.68, 95% CI 1.70 to 34.61); admission to intensive care unit (8 studies; n=6660; RR 3.81, 95% CI 2.03 to 7.17); receiving mechanical ventilation (7 studies; n=4887; RR 15.23, 95% CI 4.32 to 53.71); receiving any critical care (7 studies; n=4735; RR 5.48, 95% CI 2.57 to 11.72); and being diagnosed with pneumonia (6 studies; n=4573; RR 23.46, 95% CI 3.03 to 181.39) and thromboembolic disease (8 studies; n=5146; RR 5.50, 95% CI 1.12 to 27.12).Neonates born to women with SARS-CoV-2 infection were more likely to be admitted to a neonatal care unit after birth (7 studies; n=7637; RR 1.86, 95% CI 1.12 to 3.08); be born preterm (7 studies; n=6233; RR 1.71, 95% CI 1.28 to 2.29) or moderately preterm (7 studies; n=6071; RR 2.92, 95% CI 1.88 to 4.54); and to be born low birth weight (12 studies; n=11 930; RR 1.19, 95% CI 1.02 to 1.40). Infection was not linked to stillbirth. Studies were generally at low or moderate risk of bias.Conclusions This analysis indicates that SARS-CoV-2 infection at any time during pregnancy increases the risk of maternal death, severe maternal morbidities and neonatal morbidity, but not stillbirth or intrauterine growth r
AU  - Smith,ER
AU  - Oakley,E
AU  - Grandner,GW
AU  - Ferguson,K
AU  - Farooq,F
AU  - Afshar,Y
AU  - Ahlberg,M
AU  - Ahmadzia,H
AU  - Akelo,V
AU  - Aldrovandi,G
AU  - Barr,BAT
AU  - Bevilacqua,E
AU  - Brandt,JS
AU  - Broutet,N
AU  - Buhigas,IF
AU  - Carrillo,J
AU  - Clifton,R
AU  - Conry,J
AU  - Cosmi,E
AU  - Crispi,F
AU  - Crovetto,F
AU  - Delgado-Lopez,C
AU  - Divakar,H
AU  - Driscoll,AJ
AU  - Favre,G
AU  - Flaherman,VJ
AU  - Gale,C
AU  - Gil,MM
AU  - Gottlieb,SL
AU  - Gratacos,E
AU  - Hernandez,O
AU  - Jones,S
AU  - Kalafat,E
AU  - Khagayi,S
AU  - Knight,M
AU  - Kotloff,K
AU  - Lanzone,A
AU  - Le,Doare K
AU  - Lees,C
AU  - Litman,E
AU  - Lokken,EM
AU  - Laurita,Longo V
AU  - Madhi,SA
AU  - Magee,LA
AU  - Martinez-Portilla,RJ
AU  - McClure,EM
AU  - Metz,TD
AU  - Miller,ES
AU  - Money,D
AU  - Moungmaithong,S
AU  - Mullins,E
AU  - Nachega,JB
AU  - Nunes,MC
AU  - Onyango,D
AU  - Panchaud,A
AU  - Poon,LC
AU  - Raiten,D
AU  - Regan,L
AU  - Rukundo,G
AU  - Sahota,D
AU  - Sakowicz,A
AU  - Sanin-Blair,J
AU  - Soderling,J
AU  - Stephansson,O
AU  - Temmerman,M
AU  - Thorson,A
AU  - Tolosa,JE
AU  - Townson,J
AU  - Valencia-Prado,M
AU  - Visentin,S
AU  - von,Dadelszen P
AU  - Waldorf,KA
AU  - Whitehead,C
AU  - Yassa,M
AU  - Tielsch,JM
DO  - 10.1136/bmjgh-2022-009495
EP  - 19
PY  - 2023///
SN  - 2059-7908
SP  - 1
TI  - Adverse maternal, fetal, and newborn outcomes among pregnant women with SARS-CoV-2 infection: an individual participant data meta-analysis
T2  - BMJ Global Health
UR  - http://dx.doi.org/10.1136/bmjgh-2022-009495
UR  - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000926228300001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb
UR  - https://gh.bmj.com/content/8/1/e009495
UR  - http://hdl.handle.net/10044/1/104684
VL  - 8
ER  -
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