Imperial College London

ProfessorCarelLe Roux

Faculty of MedicineDepartment of Metabolism, Digestion and Reproduction

Visiting Professor
 
 
 
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Contact

 

+44 (0)7970 719 453c.leroux

 
 
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Location

 

08, east wingCharing Cross HospitalCharing Cross Campus

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Summary

 

Publications

Publication Type
Year
to

345 results found

Murphy CF, Elliott JA, Docherty NG, Mohamed AA, Vincent RP, Ravi N, Reynolds J, le Roux CWet al., 2021, Exaggerated postprandial GLP-1 secretion following esophagectomy is not associated with gastric emptying and intestinal transit, DISEASES OF THE ESOPHAGUS, Vol: 34, ISSN: 1120-8694

Journal article

Murphy CF, Fanning M, Raftery N, Elliott JA, Docherty NG, Donohoe CL, Ravi N, le Roux CW, Reynolds Jet al., 2021, Early experience with a nutrition and survivorship clinic in esophageal cancer, DISEASES OF THE ESOPHAGUS, Vol: 34, ISSN: 1120-8694

Journal article

Moffett RC, Docherty NG, le Roux CW, 2021, The altered enteroendocrine reportoire following roux-en-Y-gastric bypass as an effector of weight loss and improved glycaemic control, APPETITE, Vol: 156, ISSN: 0195-6663

Journal article

Braga TG, Coelho de Souza MDG, Menezes M, Nogueira Neto JF, Dellatorre-Teixeira L, Bouskela E, le Roux CW, Kraemer-Aguiar LGet al., 2021, Dipeptidyl peptidase-4 activity, lipopolysaccharide, C-reactive protein, glucose metabolism, and gut peptides 3 months after bariatric surgery, SURGERY FOR OBESITY AND RELATED DISEASES, Vol: 17, Pages: 113-120, ISSN: 1550-7289

Journal article

Sudlow AC, le Roux CW, 2021, Why are adolescents with obesity and diabetes not having bariatric surgery earlier?, Surg Obes Relat Dis, Vol: 17, Pages: 33-35

Journal article

Hankir MK, Langseder T, Bankoglu EE, Ghoreishi Y, Dischinger U, Kurlbaum M, Kroiss M, Otto C, le Roux CW, Arora T, Seyfried F, Schlegel Net al., 2020, Simulating the Post-gastric Bypass Intestinal Microenvironment Uncovers a Barrier-Stabilizing Role for FXR, ISCIENCE, Vol: 23

Journal article

McGlone ER, Carey I, Velickovic V, Chana P, Mahawar K, Batterham RL, Hopkins J, Walton P, Kinsman R, Byrne J, Somers S, Kerrigan D, Menon V, Borg C, Ahmed A, Sgromo B, Cheruvu C, Bano G, Leonard C, Thom H, le Roux CW, Reddy M, Welbourn R, Small P, Khan OAet al., 2020, Bariatric surgery for patients with type 2 diabetes mellitus requiring insulin: Clinical outcome and cost-effectiveness analyses, PLoS Medicine, Vol: 17, Pages: 1-22, ISSN: 1549-1277

BackgroundAlthough bariatric surgery is well established as an effective treatment for patients with obesity and type 2 diabetes mellitus (T2DM), there exists reluctance to increase its availability for patients with severe T2DM. The aims of this study were to examine the impact of bariatric surgery on T2DM resolution in patients with obesity and T2DM requiring insulin (T2DM-Ins) using data from a national database and to develop a health economic model to evaluate the cost-effectiveness of surgery in this cohort when compared to best medical treatment (BMT).Methods and findingsClinical data from the National Bariatric Surgical Registry (NBSR), a comprehensive database of bariatric surgery in the United Kingdom, were extracted to analyse outcomes of patients with obesity and T2DM-Ins who underwent primary bariatric surgery between 2009 and 2017. Outcomes for this group were combined with data sourced from a comprehensive literature review in order to develop a state-transition microsimulation model to evaluate cost-effectiveness of bariatric surgery versus BMT for patients over a 5-year time horizon. The main outcome measure for the clinical study was insulin cessation at 1-year post-surgery: relative risks (RR) summarising predictive factors were determined, unadjusted, and after adjusting for variables including age, initial body mass index (BMI), duration of T2DM, and weight loss. Main outcome measures for the economic evaluation were total costs, total quality-adjusted life years (QALYs), and incremental cost-effectiveness ratio (ICER) at willingness-to-pay threshold of GBP£20,000.A total of 2,484 patients were eligible for inclusion, of which 1,847 had 1-year follow-up data (mean age of 51 years, mean initial BMI 47.2 kg/m2, and 64% female). 67% of patients no longer required insulin at 1-year postoperatively: these rates persisted for 4 years. Roux-en-Y gastric bypass (RYGB) was associated with a higher rate of insulin cessation (71.7%) than sleeve gastr

Journal article

Martin WP, le Roux CW, Docherty NG, 2020, Impact of Metabolic Surgery on Renal Injury in Pre-Clinical Models of Diabetic Kidney Disease, NEPHRON, ISSN: 1660-8151

Journal article

Martin WP, le Roux CW, 2020, Can Metabolic Surgery Be Used to Improve Access to and Outcomes of Kidney Transplantation?, OBESITY, Vol: 28, Pages: 2259-2259, ISSN: 1930-7381

Journal article

le Roux CW, 2020, COVID-19 alters thinking and management in metabolic diseases, NATURE REVIEWS ENDOCRINOLOGY, Vol: 17, Pages: 71-72, ISSN: 1759-5029

Journal article

Cohen RV, Pereira TV, le Roux CW, 2020, Frailty and Postoperative Morbidity and Mortality-Here, There, and Everywhere COMMENT & RESPONSE, JAMA SURGERY, Vol: 156, Pages: 206-207, ISSN: 2168-6254

Journal article

Shulman A, Andersson-Assarsson JC, Sjostrom CD, Jacobson P, Taube M, Sjoholm K, le Roux CW, Peltonen M, Carlsson LMS, Svensson P-Aet al., 2020, Remission and progression of pre-existing micro- and macroalbuminuria over 15 years after bariatric surgery in Swedish Obese Subjects study, INTERNATIONAL JOURNAL OF OBESITY, Vol: 45, Pages: 535-546, ISSN: 0307-0565

Journal article

Murphy CF, Stratford N, Docherty NG, Moran B, Elliott JA, Healy M-L, McMorrow JP, Ravi N, Goldstone AP, Reynolds JV, le Roux CWet al., 2020, A Pilot Study of Gut-Brain Signaling After Octreotide Therapy for Unintentional Weight Loss After Esophagectomy., J Clin Endocrinol Metab

BACKGROUND: Recurrence-free patients after esophageal cancer surgery face long-term nutritional consequences, occurring in the context of an exaggerated post-prandial gut hormone response. Acute gut hormone suppression influences brain reward signaling and eating behavior. This study aimed to suppress gut hormone secretion and characterize reward responses and eating behavior among post-esophagectomy patients with unintentional weight loss. METHODS: This pilot study prospectively studied post-operative patients with ≥10% body weight loss (BWL) beyond one year who were candidates for clinical treatment with long-acting Octreotide (LAR). Before and after four weeks of treatment, gut hormone secretion, food cue reactivity (functional MRI), eating motivation (progressive ratio task), ad libitum food intake, body composition, and symptom burden were assessed. RESULTS: 8 patients (7 male, age: mean±SD 62.8±9.4 years, post-operative BWL: 15.5±5.8%) participated. Octreotide LAR did not significantly suppress total post-prandial plasma GLP-1 response at four weeks (P=0.08). Post-prandial symptom burden improved after treatment (Sigstad score median(range): 12(2-28) vs. 8(3-18), P=0.04), but weight remained stable (Pre:68.6±12.8kg vs. Post:69.2±13.4kg, P=0.13). There was no significant change in brain reward system responses, during evaluation of high-energy or low-energy food pictures, nor their appeal rating. Moreover, treatment did not alter motivation to eat (P=0.41) nor ad libitum food intake(P=0.46). CONCLUSION: The protocol used made it feasible to characterize the gut-brain axis and eating behavior in this cohort. Inadequate suppression of gut hormone responses four weeks after Octreotide LAR administration may explain the lack of gut-brain pathway alterations. A higher dose or shorter inter-dose interval may be required to optimize the intervention.

Journal article

Martin WP, Tuohy C, Doody A, Jackson S, Canavan RJ, Slattery D, Twomey PJ, McKenna MJ, le Roux CW, Docherty NGet al., 2020, Parallel assessment of albuminuria and plasma sTNFR1 in people with type 2 diabetes and advanced chronic kidney disease provides accurate prognostication of the risks of renal decline and death, SCIENTIFIC REPORTS, Vol: 10, ISSN: 2045-2322

Journal article

Minnock D, Annibalini G, Le Roux CW, Contarelli S, Krause M, Saltarelli R, Valli G, Stocchi V, Barbieri E, De Vito Get al., 2020, Effects of acute aerobic, resistance and combined exercises on 24-h glucose variability and skeletal muscle signalling responses in type 1 diabetics, EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY, Vol: 120, Pages: 2677-2691, ISSN: 1439-6319

Journal article

Grannell A, le Roux CW, McGillicuddy D, 2020, "I am terrified of something happening to me" The lived experience of people with obesity during theCOVID-19 pandemic, CLINICAL OBESITY, Vol: 10, ISSN: 1758-8103

Journal article

Kwok S, Adam S, Ho JH, Iqbal Z, Turkington P, Razvi S, Le Roux CW, Soran H, Syed AAet al., 2020, Obesity: A critical risk factor in the COVID-19 pandemic, CLINICAL OBESITY, Vol: 10, ISSN: 1758-8103

Journal article

Silveira FC, Docherty NG, Sallet PC, Moraes M, Monclaro T, Arruda e Silva M, Pizani CE, Sallet JA, le Roux CWet al., 2020, Early Post-operative Weight Change After Roux-en-Y Gastric Bypass Predicts Weight Loss at 12-Month Follow-up, OBESITY SURGERY, Vol: 30, Pages: 5020-5025, ISSN: 0960-8923

Journal article

le Roux CW, Ottosson J, Naslund E, Cohen R, Stenberg E, Sundbom M, Naslund Iet al., 2020, Bariatric Surgery: There Is a Room for Improvement to Reduce Mortality in Patients with Type 2 Diabetes, OBESITY SURGERY, Vol: 31, Pages: 461-463, ISSN: 0960-8923

Journal article

Martin WP, Bauer J, Coleman J, Dellatorre-Teixeira L, Reeve JLV, Twomey PJ, Docherty NG, O'Riordan A, Watson AJ, le Roux CW, Holian Jet al., 2020, Obesity is common in chronic kidney disease and associates with greater antihypertensive usage and proteinuria: evidence from a cross-sectional study in atertiary nephrology centre, CLINICAL OBESITY, Vol: 10, ISSN: 1758-8103

Journal article

Martin WP, White J, Lopez-Hernandez FJ, Docherty NG, le Roux CWet al., 2020, Metabolic Surgery to Treat Obesity in Diabetic Kidney Disease, Chronic Kidney Disease, and End-Stage Kidney Disease; What Are the Unanswered Questions?, FRONTIERS IN ENDOCRINOLOGY, Vol: 11, ISSN: 1664-2392

Journal article

Docherty NG, le Roux CW, 2020, Bariatric surgery for the treatment of chronic kidney disease in obesity and type 2 diabetes mellitus, NATURE REVIEWS NEPHROLOGY, Vol: 16, Pages: 709-720, ISSN: 1759-5061

Journal article

Cohen RV, Pereira TV, Aboud CM, Zanata Petry TB, Lopes Correa JL, Schiavon CA, Pompilio CE, Quirino Pechy FN, Calmon da Costa Silva AC, Gomes de Melo FL, Cunha da Silveira LP, de Paris Caravatto PP, Halpern H, Jacy Monteiro FDL, Martins BDC, Kuga R, Sarian Palumbo TM, Docherty NG, le Roux CWet al., 2020, Effect of Gastric Bypass vs Best Medical Treatment on Early-Stage Chronic Kidney Disease in Patients With Type 2 Diabetes and Obesity A Randomized Clinical Trial, JAMA SURGERY, Vol: 155, ISSN: 2168-6254

Journal article

Wallenius V, Elias E, Elebring E, Haisma B, Casselbrant A, Larraufie P, Spak E, Reimann F, le Roux CW, Docherty NG, Gribble FM, Fandriks Let al., 2020, Suppression of enteroendocrine cell glucagon-like peptide (GLP)-1 release by fat-induced small intestinal ketogenesis: a mechanism targeted by Roux-en-Y gastric bypass surgery but not by preoperative very-low-calorie diet, GUT, Vol: 69, Pages: 1423-1431, ISSN: 0017-5749

Journal article

Hopkins M, Andrews R, Salem V, Taylor R, le Roux CW, Robertson E, Burns Eet al., 2020, Improving understanding of type 2 diabetes remission: research recommendations from Diabetes UK's 2019 remission workshop, DIABETIC MEDICINE, Vol: 37, Pages: 1944-1950, ISSN: 0742-3071

Journal article

Grannell A, Fallon F, Pournaras D, le Roux CWet al., 2020, Exploring patient beliefs and perceptions regarding obesity as a disease, obesity causation and treatment, IRISH JOURNAL OF MEDICAL SCIENCE, Vol: 190, Pages: 163-168, ISSN: 0021-1265

Journal article

Rubino F, Cohen R, Mingrone G, le Roux CW, Mechanick J, Arterburn DE, Vidal J, Alberti G, Amiel SA, Batterham RL, Bornstein S, Chamseddine G, Del Prato S, Dixon JB, Eckel RH, Hopkins D, McGowan BM, Pan A, Patel A, Pattou F, Schauer PR, Zimmet PZ, Cummings DEet al., 2020, Bariatric and metabolic surgery during and after the COVID-19 pandemic: DSS recommendations for management of surgical candidates and postoperative patients and prioritisation of access to surgery, LANCET DIABETES & ENDOCRINOLOGY, Vol: 8, Pages: 640-648, ISSN: 2213-8587

Journal article

Sultan S, Patel AG, El-Hassani S, Whitelaw B, Leca BM, Vincent RP, le Roux CW, Rubino F, Aywlin SJB, Dimitriadis GKet al., 2020, Male Obesity Associated Gonadal Dysfunction and the Role of Bariatric Surgery, FRONTIERS IN ENDOCRINOLOGY, Vol: 11, ISSN: 1664-2392

Journal article

Gomide Braga T, das Gracas Coelho de Souza M, Maranhao PA, Menezes M, Dellatorre-Teixeira L, Bouskela E, Le Roux CW, Kraemer-Aguiar LGet al., 2020, Evaluation of Heart Rate Variability and Endothelial Function 3 Months After Bariatric Surgery, OBESITY SURGERY, Vol: 30, Pages: 2450-2453, ISSN: 0960-8923

Journal article

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