Imperial College London
Alternate

ProfessorCarelLe Roux

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Visiting Professor
 
 
 
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Contact

 

+44 (0)7970 719 453c.leroux

 
 
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Location

 

08, east wingCharing Cross HospitalCharing Cross Campus

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Summary

 

Publications

Publication Type
Year
to

345 results found

Sultan S, Patel AG, El-Hassani S, Whitelaw B, Leca BM, Vincent RP, le Roux CW, Rubino F, Aywlin SJB, Dimitriadis GKet al., 2020, Male Obesity Associated Gonadal Dysfunction and the Role of Bariatric Surgery, FRONTIERS IN ENDOCRINOLOGY, Vol: 11, ISSN: 1664-2392

Journal article

Gomide Braga T, das Gracas Coelho de Souza M, Maranhao PA, Menezes M, Dellatorre-Teixeira L, Bouskela E, Le Roux CW, Kraemer-Aguiar LGet al., 2020, Evaluation of Heart Rate Variability and Endothelial Function 3 Months After Bariatric Surgery, OBESITY SURGERY, Vol: 30, Pages: 2450-2453, ISSN: 0960-8923

Journal article

le Roux CW, 2020, Biography: Carel le Roux, OBESITY SURGERY, Vol: 30, Pages: 2074-2075, ISSN: 0960-8923

Journal article

Neff KJ, Le Roux CW, 2020, The Effect of Metabolic Surgery on the Complications of Diabetes: What Are the Unanswered Questions?, FRONTIERS IN ENDOCRINOLOGY, Vol: 11, ISSN: 1664-2392

Journal article

Sudlow AC, Le Roux CW, Pournaras DJ, 2020, Long-term outcomes of bariatric surgery in patients with diabetes, EXPERT REVIEW OF ENDOCRINOLOGY & METABOLISM, Vol: 15, Pages: 141-146, ISSN: 1744-6651

Journal article

Wilkinson M, Murphy S, Sinclair P, Heneghan H, le Roux CW, Brennan DJet al., 2020, Patient perceptions and understanding of obesity related endometrial cancer, GYNECOLOGIC ONCOLOGY REPORTS, Vol: 32, ISSN: 2352-5789

Journal article

Hyde KM, Blonde GD, Bueter M, le Roux CW, Spector ACet al., 2020, Gastric bypass in female rats lowers concentrated sugar solution intake an preference without affecting brief-access licking after long-term sugar exposure, AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, Vol: 318, Pages: R870-R885, ISSN: 0363-6119

Journal article

Rubino F, Puhl RM, Cummings DE, Eckel RH, Ryan DH, Mechanick J, Nadglowski J, Salas XR, Schauer PR, Twenefour D, Apovian CM, Aronne LJ, Batterham RL, Berthoud H-R, Boza C, Busetto L, Dicker D, De Groot M, Eisenberg D, Flint SW, Huang TT, Kaplan LM, Kirwan JP, Korner J, Kyle TK, Laferrere B, le Roux CW, McIver L, Mingrone G, Nece P, Reid TJ, Rogers AM, Rosenbaum M, Seeley RJ, Torres AJ, Dixon JBet al., 2020, Joint international consensus statement for ending stigma of obesity, NATURE MEDICINE, Vol: 26, Pages: 485-497, ISSN: 1078-8956

Journal article

Nielsen MS, Ritz C, Albrechtsen NJW, Holst JJ, le Roux CW, Sjodin Aet al., 2020, Oxyntomodulin and Glicentin May Predict the Effect of Bariatric Surgery on Food Preferences and Weight Loss, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol: 105, ISSN: 0021-972X

Journal article

McCrimmon RJ, Catarig A-M, Frias JP, Lausvig NL, le Roux CW, Thielke D, Lingvay Iet al., 2020, Effects of once-weekly semaglutide vs once-daily canagliflozin on body composition in type 2 diabetes: a substudy of the SUSTAIN 8 randomised controlled clinical trial, DIABETOLOGIA, Vol: 63, Pages: 473-485, ISSN: 0012-186X

Journal article

Sudlow A, le Roux CW, Pournaras DJ, 2020, The metabolic benefits of different bariatric operations: what procedure to choose?, ENDOCRINE CONNECTIONS, Vol: 9, Pages: R28-R35

Journal article

Martin WP, le Roux CW, 2020, Comment on: Impact of serum uric acid on renal function after bariatric surgery: a retrospective study comment, SURGERY FOR OBESITY AND RELATED DISEASES, Vol: 16, Pages: 295-298, ISSN: 1550-7289

Journal article

Nair M, Martin WP, Zhernovkov V, Elliott JA, Fearon N, Eckhardt H, McCormack J, Godson C, Brennan EP, Marai M, Fandriks L, Docherty NG, le Roux CWet al., 2020, Characterization of the renal cortical transcriptome following Roux-en-Y gastric bypass surgery in experimental diabetic kidney disease, BMJ OPEN DIABETES RESEARCH & CARE, Vol: 8

Journal article

Canney AL, Cohen R, Elliotti JA, Aboud CM, Martini WP, Docherty NG, le Roux CWet al., 2020, Improvements in diabetic albuminuria and podocyte differentiation following Roux-en-Y gastric bypass surgery, DIABETES & VASCULAR DISEASE RESEARCH, Vol: 17, ISSN: 1479-1641

Journal article

Grannell A, Al-Najim W, Mangan A, Kapoor N, Martin WP, Murphy JC, Docherty NG, le Roux CW, Davenport Cet al., 2019, Fat free mass is positively associated with hunger and energy intake at extremes of obesity, APPETITE, Vol: 143, ISSN: 0195-6663

Journal article

Sudlow AC, le Roux CW, Pournaras DJ, 2019, Review of Advances in Anti-obesity Pharmacotherapy: Implications for a Multimodal Treatment Approach with Metabolic Surgery, OBESITY SURGERY, Vol: 29, Pages: 4095-4104, ISSN: 0960-8923

Journal article

Friedman AN, Wang J, Wahed AS, Docherty NG, Fennern E, Pomp A, Purnell JQ, le Roux CW, Wolfe Bet al., 2019, The Association Between Kidney Disease and Diabetes Remission in Bariatric Surgery Patients With Type 2 Diabetes, AMERICAN JOURNAL OF KIDNEY DISEASES, Vol: 74, Pages: 761-770, ISSN: 0272-6386

Journal article

Nielsen MS, Andersen INSK, Lange B, Ritz C, le Roux CW, Schmidt JB, Sjodin A, Bredie WLPet al., 2019, Bariatric Surgery Leads to Short-Term Effects on Sweet Taste Sensitivity and Hedonic Evaluation of Fatty Food Stimuli, OBESITY, Vol: 27, Pages: 1796-1804, ISSN: 1930-7381

Journal article

Kokkinos A, Tsilingiris D, le Roux CW, Rubino F, Mantzoros CSet al., 2019, Will medications that mimic gut hormones or target their receptors eventually replace bariatric surgery?, METABOLISM-CLINICAL AND EXPERIMENTAL, Vol: 100, ISSN: 0026-0495

Journal article

Lingvay I, Catarig A-M, Frias JP, Kumar H, Lausvig NL, le Roux CW, Thielke D, Viljoen A, McCrimmon RJet al., 2019, Efficacy and safety of once-weekly semaglutide versus daily canagliflozin as add-on to metformin in patients with type 2 diabetes (SUSTAIN 8): a double-blind, phase 3b, randomised controlled trial, LANCET DIABETES & ENDOCRINOLOGY, Vol: 7, Pages: 834-844, ISSN: 2213-8587

Journal article

Holland JA, Martin WP, Docherty NG, le Roux CWet al., 2019, Impact of intentional weight loss on diabetic kidney disease, DIABETES OBESITY & METABOLISM, Vol: 21, Pages: 2338-2341, ISSN: 1462-8902

Journal article

Sudlow A, le Roux CW, Pournaras DJ, 2019, Review of multimodal treatment for type 2 diabetes: combining metabolic surgery and pharmacotherapy, THERAPEUTIC ADVANCES IN ENDOCRINOLOGY AND METABOLISM, Vol: 10, ISSN: 2042-0188

Journal article

Mangan AM, Al Najim W, McNamara N, Martin WP, Antanaitis A, Bleiel SB, Kent RM, le Roux CW, Docherty NGet al., 2019, Effect of Macronutrient Type and Gastrointestinal Release Site on PYY Response in Normal Healthy Subjects, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol: 104, Pages: 3661-3669, ISSN: 0021-972X

Journal article

Nielsen MS, Schmidt JB, le Roux CW, Sjodin Aet al., 2019, Effects of Roux-en-Y Gastric Bypass and Sleeve Gastrectomy on Food Preferences and Potential Mechanisms Involved, CURRENT OBESITY REPORTS, Vol: 8, Pages: 292-300, ISSN: 2162-4968

Journal article

Casella-Mariolo J, Castagneto-Gissey L, Angelini G, Zoli A, Marini P, Bornstein SR, Pournaras DJ, Rubino F, le Roux CW, Mingrone G, Casella Get al., 2019, Simulation of gastric bypass effects on glucose metabolism and non-alcoholic fatty liver disease with the Sleeveballoon device, EBIOMEDICINE, Vol: 46, Pages: 452-462, ISSN: 2352-3964

Journal article

Behary P, Tharakan G, Alexiadou K, Johnson N, Wewer Albrechtsen NJ, Kenkre J, Cuenco J, Hope D, Anyiam O, Choudhury S, Alessimii H, Poddar A, Minnion J, Doyle C, Frost G, Le Roux C, Purkayastha S, Moorthy K, Dhillo W, Holst JJ, Ahmed AR, Prevost AT, Bloom SR, Tan TMet al., 2019, Combined GLP-1, oxyntomodulin, and peptide YY improves body weight and glycemia in obesity and prediabetes/type 2 diabetes: a randomized single-blinded placebo controlled study, Diabetes Care, Vol: 42, Pages: 1446-1453, ISSN: 0149-5992

OBJECTIVE: Roux-en-Y gastric bypass (RYGB) augments postprandial secretion of glucagon-like peptide 1 (GLP-1), oxyntomodulin (OXM), and peptide YY (PYY). Subcutaneous infusion of these hormones ("GOP"), mimicking postprandial levels, reduces energy intake. Our objective was to study the effects of GOP on glycemia and body weight when given for 4 weeks to patients with diabetes and obesity. RESEARCH DESIGN AND METHODS: In this single-blinded mechanistic study, obese patients with prediabetes/diabetes were randomized to GOP (n = 15) or saline (n = 11) infusion for 4 weeks. We also studied 21 patients who had undergone RYGB and 22 patients who followed a very low-calorie diet (VLCD) as unblinded comparators. Outcomes measured were 1) body weight, 2) fructosamine levels, 3) glucose and insulin during a mixed meal test (MMT), 4) energy expenditure (EE), 5) energy intake (EI), and 6) mean glucose and measures of glucose variability during continuous glucose monitoring. RESULTS: GOP infusion was well tolerated over the 4-week period. There was a greater weight loss (P = 0.025) with GOP (mean change -4.4 [95% CI -5.3, -3.5] kg) versus saline (-2.5 [-4.1, -0.9] kg). GOP led to a greater improvement (P = 0.0026) in fructosamine (-44.1 [-62.7, -25.5] µmol/L) versus saline (-11.7 [-18.9, -4.5] µmol/L). Despite a smaller weight loss compared with RYGB and VLCD, GOP led to superior glucose tolerance after a mixed-meal stimulus and reduced glycemic variability compared with RYGB and VLCD. CONCLUSIONS: GOP infusion improves glycemia and reduces body weight. It achieves superior glucose tolerance and reduced glucose variability compared with RYGB and VLCD. GOP is a viable alternative for the treatment of diabetes with favorable effects on body weight.

Journal article

Dehestani B, le Roux CW, 2019, The Role of the Small Bowel in Unintentional Weight Loss after Treatment of Upper Gastrointestinal Cancers, JOURNAL OF CLINICAL MEDICINE, Vol: 8

Journal article

Suliman M, Buckley A, Al Tikriti A, Tan T, le Roux CW, Lessan N, Barakat Met al., 2019, Routine clinical use of liraglutide 3 mg for the treatment of obesity: Outcomes in non-surgical and bariatric surgery patients, DIABETES OBESITY & METABOLISM, Vol: 21, Pages: 1498-1501, ISSN: 1462-8902

Journal article

Martin WP, le Roux CW, 2019, Comment on: Metabolic surgery improves renal injury independent of weight loss: a meta-analysis, SURGERY FOR OBESITY AND RELATED DISEASES, Vol: 15, Pages: 1020-1023, ISSN: 1550-7289

Journal article

Elliott JA, Docherty NG, Murphy CF, Eckhardt H-G, Doyle SL, Guinan EM, Ravi N, Reynolds JV, le Roux CWet al., 2019, Changes in gut hormones, glycaemic response and symptoms after oesophagectomy, BRITISH JOURNAL OF SURGERY, Vol: 106, Pages: 735-746, ISSN: 0007-1323

Journal article

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