Publications
345 results found
Laurenius A, Werling M, Le Roux CW, et al., 2014, More symptoms but similar blood glucose curve after oral carbohydrate provocation in patients with a history of hypoglycemia-like symptoms compared to asymptomatic patients after Roux-en-Y gastric bypass, SURGERY FOR OBESITY AND RELATED DISEASES, Vol: 10, Pages: 1047-1054, ISSN: 1550-7289
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- Citations: 26
Taylor DR, Alaghband-Zadeh J, Cross GF, et al., 2014, Urine Bile Acids Relate to Glucose Control in Patients with Type 2 Diabetes Mellitus and a Body Mass Index Below 30 kg/m<SUP>2</SUP>, PLOS ONE, Vol: 9, ISSN: 1932-6203
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- Citations: 21
Salinari S, le Roux CW, Bertuzzi A, et al., 2014, Duodenal-Jejunal Bypass and Jejunectomy Improve Insulin Sensitivity in Goto-Kakizaki Diabetic Rats Without Changes in Incretins or Insulin Secretion, DIABETES, Vol: 63, Pages: 1069-1078, ISSN: 0012-1797
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- Citations: 50
Miras AD, le Roux CW, 2014, Can medical therapy mimic the clinical efficacy or physiological effects of bariatric surgery?, INTERNATIONAL JOURNAL OF OBESITY, Vol: 38, Pages: 325-333, ISSN: 0307-0565
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- Citations: 45
Miras AD, le Roux CW, 2014, Metabolic surgery: shifting the focus from glycaemia and weight to end-organ health, LANCET DIABETES & ENDOCRINOLOGY, Vol: 2, Pages: 141-151, ISSN: 2213-8587
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- Citations: 24
Pournaras DJ, le Roux CW, 2014, Can we predict diabetes remission after weight-loss surgery?, LANCET DIABETES & ENDOCRINOLOGY, Vol: 2, Pages: 4-6, ISSN: 2213-8587
Miras AD, Risstad H, Baqai N, et al., 2014, Application of the International Diabetes Federation and American Diabetes Association criteria in the assessment of metabolic control after bariatric surgery, DIABETES OBESITY & METABOLISM, Vol: 16, Pages: 86-89, ISSN: 1462-8902
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- Citations: 15
Neff KJ, Prener C, Chuah LL, et al., 2014, A holistic assessment of bariatric surgical outcomes in a Northern Irish cohort., Ir Med J, Vol: 107, Pages: 24-26, ISSN: 0332-3102
The King's Obesity Staging system was developed to evaluate the effect of obesity treatments in multiple physical, psychological and functional domains. In this prospective cohort study, a Northern Irish cohort was scored using the King's Obesity Staging system before and 1 year after bariatric surgery. 71 individuals underwent surgery and 31 (44%) had type 2 diabetes. Bariatric surgery improved each health domain (p < 0.05). A subgroup with type 2 diabetes showed a significantly greater improvement in gonadal disease (polycystic ovarian syndrome and sub-fertility) (p = 0.02), and a trend towards greater improvement in cardiovascular disease (p = 0.07) compared with the non-diabetic subgroup. Half of those with pre-diabetes were normoglycaemic postoperatively (p < 0.05). The King's Obesity Staging system can be used to holistically evaluate the outcomes of bariatric surgery. Patients benefit from bariatric surgery in many ways, but those with diabetes may benefit more.
Baechler T, Schiesser M, Lutz TA, et al., 2014, Where to Begin and Where to End? Preoperative Assessment for Patients Undergoing Metabollic Surgery, DIGESTIVE SURGERY, Vol: 31, Pages: 25-32, ISSN: 0253-4886
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- Citations: 5
Le Roux C, Miras A, Risstad H, et al., 2013, Application of the International Diabetes Federation and American Diabetes Association Criteria in the Assessment of Metabolic Control After Bariatric Surgery, OBESITY SURGERY, Vol: 23, Pages: 1147-1147, ISSN: 0960-8923
Cohen R, le Roux CW, Papamargaritis D, et al., 2013, Role of proximal gut exclusion from food on glucose homeostasis in patients with Type 2 diabetes, DIABETIC MEDICINE, Vol: 30, Pages: 1482-1486, ISSN: 0742-3071
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- Citations: 33
Seyfried F, Miras AD, Bueter M, et al., 2013, Effects of preoperative exposure to a high-fat versus a low-fat diet on ingestive behavior after gastric bypass surgery in rats, SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES, Vol: 27, Pages: 4192-4201, ISSN: 0930-2794
Neff KJ, Frankel AH, Tam FWK, et al., 2013, The effect of bariatric surgery on renal function and disease: a focus on outcomes and inflammation, NEPHROLOGY DIALYSIS TRANSPLANTATION, Vol: 28, Pages: 73-82, ISSN: 0931-0509
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- Citations: 32
Werling M, Vincent RP, Cross GF, et al., 2013, Enhanced fasting and post-prandial plasma bile acid responses after Roux-en-Y gastric bypass surgery, SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, Vol: 48, Pages: 1257-1264, ISSN: 0036-5521
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- Citations: 60
Pournaras DJ, le Roux CW, 2013, Preventing Type 2 Diabetes, CVD, and Mortality: Surgical Versus Non-surgical Weight Loss Strategies, CURRENT ATHEROSCLEROSIS REPORTS, Vol: 15, ISSN: 1523-3804
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- Citations: 4
Lyons T, Neff KJ, Benn J, et al., 2013, Body mass index and diabetes status do not affect postoperative infection rates after bariatric surgery, SURGERY FOR OBESITY AND RELATED DISEASES, Vol: 10, Pages: 291-297, ISSN: 1550-7289
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- Citations: 12
Miras AD, le Roux CW, 2013, Mechanisms underlying weight loss after bariatric surgery, NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY, Vol: 10, Pages: 575-584, ISSN: 1759-5045
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- Citations: 219
Neff KJ, Miras AD, le Roux C, 2013, Duodenal-jejunal bypass liners: outcomes in glycaemic control and weight loss, CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY, Vol: 20, Pages: 420-428, ISSN: 1752-296X
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- Citations: 3
de Jonge C, Rensen SS, Verdam FJ, et al., 2013, Endoscopic Duodenal-Jejunal Bypass Liner Rapidly Improves Type 2 Diabetes, OBESITY SURGERY, Vol: 23, Pages: 1354-1360, ISSN: 0960-8923
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- Citations: 113
Sam A, Busbridge M, Amin A, et al., 2013, Hepcidin levels in diabetes mellitus and polycystic ovary syndrome, Diabetic Medicine, Vol: 30, Pages: 1495-1499, ISSN: 0742-3071
Osto M, Abegg K, Bueter M, et al., 2013, Roux-en-Y gastric bypass surgery in rats alters gut microbiota profile along the intestine, PHYSIOLOGY & BEHAVIOR, Vol: 119, Pages: 92-96, ISSN: 0031-9384
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- Citations: 74
Vincent RP, Omar S, Ghozlan S, et al., 2013, Higher circulating bile acid concentrations in obese patients with type 2 diabetes, ANNALS OF CLINICAL BIOCHEMISTRY, Vol: 50, Pages: 360-364, ISSN: 0004-5632
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- Citations: 61
Pournaras DJ, le Roux CW, 2013, Are Bile Acids the New Gut Hormones? Lessons From Weight Loss Surgery Models, ENDOCRINOLOGY, Vol: 154, Pages: 2255-2256, ISSN: 0013-7227
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- Citations: 33
Elliott JA, Patel VM, Kirresh A, et al., 2013, Fast-track laparoscopic bariatric surgery: a systematic review., Updates Surg, Vol: 65, Pages: 85-94, ISSN: 2038-131X
This study aimed to systematically evaluate the evidence-based literature on fast-track laparoscopic Roux-en-Y gastric bypass (LRYGB) and laparoscopic adjustable gastric banding (LAGB) to determine the feasibility and safety of fast-track laparoscopic bariatric surgery. A literature search of PubMed, EMBASE and Cochrane Library using the MeSH terms "bariatric surgery", "ambulatory surgical procedures" and related terms as keywords was performed. The study included articles that reported on intended next-day discharge for LRYGB and same-day discharge for LAGB. Data were extracted on study design and size, patient demographics, patient-selection criteria, patient preparation, perioperative management, operative details, clinical outcomes, and follow-up. The review included 13 studies classified as level 3b or 4 evidence. There were seven studies that investigated LAGB, five studies investigated LRYGB and one study detailed outcomes from both LRYGB and LAGB. Next-day discharge rate ranged from 81 to 100 % for LRYGB. Same-day discharge rate ranged from 76 to 98 % for LAGB. In LRYGB and LAGB complication, re-admission and mortality rates (≤10.5, ≤7.5, ≤0.1 %, respectively) were comparable with the conventional perioperative care. From our results, the fast-track management of patients undergoing LRYGB and LAGB is feasible. With careful patient selection and preparation within high-volume centres, and application of care pathways including close outpatient follow-up, outcomes for fast-track bariatric procedures can compare favourably with those reported in the literature for standard management, but with decreased cost. However, further studies from independent researchers are required to determine the safety of a generalised adoption of this approach outside of dedicated bariatric units, and to formally demonstrate the cost-benefit of fast-track bariatric surgery.
Werling M, Olbers T, Fandriks L, et al., 2013, Increased Postprandial Energy Expenditure May Explain Superior Long Term Weight Loss after Roux-en-Y Gastric Bypass Compared to Vertical Banded Gastroplasty, PLOS ONE, Vol: 8, ISSN: 1932-6203
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- Citations: 62
Neff KJ, O'Shea D, le Roux CW, 2013, Glucagon like peptide-1 (GLP-1) dynamics following bariatric surgery: a Signpost to a new frontier., Curr Diabetes Rev, Vol: 9, Pages: 93-101
Glucagon like peptide-1 (GLP-1) is one of the gastrointestinal peptides implicated in glycaemic homeostasis. In non-obese individuals with normal glucose tolerance GLP-1 is secreted in response to nutrient intake. However, this GLP- 1 response is generally accepted to be significantly diminished in those with diabetes, obesity or both. Given that GLP-1 is secreted from enteroendocrine L cells in the intestine, it is not surprising that manipulation of the gastro- intestinal tract has been shown to alter GLP-1 secretion; particularly when this intestinal manipulation is designed to aid weight reduction. GLP-1 dynamics are altered by bariatric surgery, with an improved secretory response to nutrient intake. However, there remains debate on the mechanisms responsible for the alterations in GLP-1 dynamics. Here we review the evidence for GLP-1 dynamics after Roux-en-Y gastric bpyass (RYGB), adjustable gastric banding (AGB), biliopancreatic diversion (BPD) and sleeve gastrectomy (SG), and make comparisons between modalities. In addition, we review the potential mechanisms underlying these dynamics, other molecules that may add to the "incretin effect" and other possible roles for GLP-1 following bariatric surgery. Finally, we will offer our critique of the evidence base.
Seyfried F, Li JV, Miras AD, et al., 2013, Urinary Phenotyping Indicates Weight Loss-Independent Metabolic Effects of Roux-en-Y Gastric Bypass in Mice, JOURNAL OF PROTEOME RESEARCH, Vol: 12, Pages: 1245-1253, ISSN: 1535-3893
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- Citations: 14
Iesari S, le Roux CW, De Gaetano A, et al., 2013, Twenty-Four Hour Energy Expenditure and Skeletal Muscle Gene Expression Changes After Bariatric Surgery, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol: 98, Pages: E321-E327, ISSN: 0021-972X
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- Citations: 11
Vincent RP, Omar S, Elnenaei MO, et al., 2013, Adherence to the national institute of clinical excellence guidance on parenteral nutrition screening is not enough to improve outcomes, CLINICAL NUTRITION, Vol: 32, Pages: 73-76, ISSN: 0261-5614
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- Citations: 5
Neff KJH, le Roux CW, 2013, Bariatric surgery: a best practice article, JOURNAL OF CLINICAL PATHOLOGY, Vol: 66, Pages: 90-98, ISSN: 0021-9746
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- Citations: 34
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