Publications
300 results found
Lloyd C, Cullinan P, 2015, Year in review 2014: basic science and epidemiology, Thorax, Vol: 70, Pages: 581-584, ISSN: 1468-3296
Lloyd CM, Saglani S, 2015, Epithelial cytokines and pulmonary allergic inflammation, Current Opinion in Immunology, Vol: 34, Pages: 52-58, ISSN: 1879-0372
The triad of epithelial derived cytokines, IL-25, IL-33 and TSLP are important for the initiation and development of pulmonary immune responses to environmental stimuli. Data from experiments using mouse models provide compelling evidence for their involvement in both innate and adaptive immunity to drive type-2 responses, allergic inflammation and airway remodelling. These cytokines are known to be expressed in human lung tissue and immune cells, however their involvement in mediating allergic pulmonary responses in patients is less clear than in murine models of disease. This article focuses on evidence for the role of IL-25, IL-33 and TSLP in human allergic disease and discusses their potential as therapeutic targets for severe asthma.
Lloyd CM, 2015, Special delivery: How macrophages get the message across, JOURNAL OF EXPERIMENTAL MEDICINE, Vol: 212, Pages: 598-598, ISSN: 0022-1007
Lee DC, Walker SA, Byrne AJ, et al., 2015, Perinatal paracetamol exposure in mice does not affect the development of allergic airways disease in early life., Thorax, ISSN: 1468-3296
Current data concerning maternal paracetamol intake during pregnancy, or intake during infancy and risk of wheezing or asthma in childhood is inconclusive based on epidemiological studies. We have investigated whether there is a causal link between maternal paracetamol intake during pregnancy and lactation and the development of house dust mite (HDM) induced allergic airways disease (AAD) in offspring using a neonatal mouse model.
Johnson JR, Folestad E, Rowley JE, et al., 2015, Pericytes contribute to airway remodeling in a mouse model of chronic allergic asthma, AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, Vol: 308, Pages: L658-L671, ISSN: 1040-0605
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- Citations: 28
Nagakumar P, Denney L, Fleming L, et al., 2015, Type 2 Innate Lymphoid Cells Are Increased In Bal And Induced Sputum But Not Blood In Children With Severe Therapy Resistant Asthma (stra), International Conference of the American-Thoracic-Society (ATS), Publisher: AMER THORACIC SOC, ISSN: 1073-449X
Denney L, Gregory LG, Shea TJ, et al., 2014, Pulmonary epithelial-derived TGF-β1 is critical for the inception of innate lymphoid cell mediated allergic airways disease, Publisher: WILEY-BLACKWELL, Pages: 41-41, ISSN: 0019-2805
Loeser S, Zhang Y, Gregory L, et al., 2014, Novel insights into the <i>in vivo</i> function of <i>Ormdl3</i> - a gene associated with the onset of childhood asthma, IMMUNOLOGY, Vol: 143, Pages: 59-59, ISSN: 0019-2805
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- Citations: 3
Lloyd CM, 2014, Chair's summary: Innate and adaptive immune responses in airway disease., Ann Am Thorac Soc, Vol: 11 Suppl 5, Pages: S234-S235
Mathie SA, Dixon KL, Walker SA, et al., 2014, Alveolar macrophages are sentinels of murine pulmonary homeostasis following inhaled antigen challenge., Allergy, Vol: 70, Pages: 80-89, ISSN: 1398-9995
Alveolar macrophages are sentinels of the pulmonary mucosa and central to maintaining immunological homeostasis. However, their role in governing the response to allergen is not fully understood. Inappropriate responses to the inhaled environment manifest as asthma.
Murdoch JR, Gregory LG, Lloyd CM, 2014, γδT cells regulate chronic airway inflammation and development of airway remodelling, CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 44, Pages: 1386-1398, ISSN: 0954-7894
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- Citations: 12
Vasiliou JE, Lui S, Walker SA, et al., 2014, Vitamin D deficiency induces Th2 skewing and eosinophilia in neonatal allergic airways disease, ALLERGY, Vol: 69, Pages: 1380-1389, ISSN: 0105-4538
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- Citations: 75
Snelgrove RJ, Gregory LG, Peiro T, et al., 2014, Alternaria-derived serine protease activity drives IL-33-mediated asthma exacerbations, Journal of Allergy and Clinical Immunology, Vol: 134, Pages: 583-592.e6, ISSN: 1097-6825
BackgroundThe fungal allergen Alternaria alternata is implicated in severe asthma and rapid onset life-threatening exacerbations of disease. However, the mechanisms that underlie this severe pathogenicity remain unclear.ObjectiveWe sought to investigate the mechanism whereby Alternaria was capable of initiating severe, rapid onset allergic inflammation.MethodsIL-33 levels were quantified in wild-type and ST2−/− mice that lacked the IL-33 receptor given inhaled house dust mite, cat dander, or Alternaria, and the effect of inhibiting allergen-specific protease activities on IL-33 levels was assessed. An exacerbation model of allergic airway disease was established whereby mice were sensitized with house dust mite before subsequently being challenged with Alternaria (with or without serine protease activity), and inflammation, remodeling, and lung function assessed 24 hours later.ResultsAlternaria, but not other common aeroallergens, possessed intrinsic serine protease activity that elicited the rapid release of IL-33 into the airways of mice through a mechanism that was dependent upon the activation of protease activated receptor-2 and adenosine triphosphate signaling. The unique capacity of Alternaria to drive this early IL-33 release resulted in a greater pulmonary inflammation by 24 hours after challenge relative to the common aeroallergen house dust mite. Furthermore, this Alternaria serine protease–IL-33 axis triggered a rapid, augmented inflammation, mucus release, and loss of lung function in our exacerbation model.
Gollwitzer ES, Saglani S, Trompette A, et al., 2014, Lung microbiota promotes tolerance to allergens in neonates via PD-L1, Nature Medicine, Vol: 20, Pages: 642-647, ISSN: 1078-8956
Epidemiological data point toward a critical period in early life during which environmental cues can set an individual on a trajectory toward respiratory health or disease1,2,3,4,5,6,7,8. The neonatal immune system matures during this period9, although little is known about the signals that lead to its maturation. Here we report that the formation of the lung microbiota is a key parameter in this process. Immediately following birth, neonatal mice were prone to develop exaggerated airway eosinophilia, release type 2 helper T cell cytokines and exhibit airway hyper-responsiveness following exposure to house dust mite allergens, even though their lungs harbored high numbers of natural CD4+Foxp3+CD25+Helios+ regulatory T (Treg) cells. During the first 2 weeks after birth, the bacterial load in the lungs increased, and representation of the bacterial phyla shifts from a predominance of Gammaproteobacteria and Firmicutes towards Bacteroidetes. The changes in the microbiota were associated with decreased aeroallergen responsiveness and the emergence of a Helios− Treg cell subset that required interaction with programmed death ligand 1 (PD-L1) for development. Absence of microbial colonization10 or blockade of PD-L1 during the first 2 weeks postpartum maintained exaggerated responsiveness to allergens through to adulthood. Adoptive transfer of Treg cells from adult mice to neonates before aeroallergen exposure ameliorated disease. Thus, formation of the airway microbiota induces regulatory cells early in life, which, when dysregulated, can lead to sustained susceptibility to allergic airway inflammation in adulthood.
Cullinan P, Lloyd CM, 2014, Year in review 2013: basic science and epidemiology, THORAX, Vol: 69, Pages: 505-507, ISSN: 0040-6376
Campbell JD, Kell SA, Kozy HM, et al., 2014, A limited CpG-containing oligodeoxynucleotide therapy regimen induces sustained suppression of allergic airway inflammation in mice, THORAX, Vol: 69, Pages: 565-573, ISSN: 0040-6376
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- Citations: 33
Saglani S, Lloyd CM, 2014, Eosinophils in the pathogenesis of paediatric severe asthma, CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 14, Pages: 143-148, ISSN: 1528-4050
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- Citations: 37
Moldaver DM, Bharhani MS, Wattie JN, et al., 2014, Amelioration of ovalbumin-induced allergic airway disease following Der p 1 peptide immunotherapy is not associated with induction of IL-35, MUCOSAL IMMUNOLOGY, Vol: 7, Pages: 379-390, ISSN: 1933-0219
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- Citations: 16
Lloyd C, Lewkowich IP, Wills-Karp M, et al., 2014, Mouse Models of Allergic Airways Disease, Middleton's Allergy: Principles and Practice: Eighth Edition, Pages: 842-860, ISBN: 9780323085939
Gregory LG, Jones CP, Mathie SA, et al., 2013, Endothelin-1 directs airway remodeling and hyper-reactivity in a murine asthma model, ALLERGY, Vol: 68, Pages: 1579-1588, ISSN: 0105-4538
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- Citations: 25
Mathie SA, Bena S, Mondae M, et al., 2013, Activation of annexin A1-FPR2 axis promotes resolution of house dust mite induced airway hyper-reactivity, Annual Congress of the British-Society-for-Immunology, Publisher: WILEY-BLACKWELL, Pages: 82-83, ISSN: 0019-2805
Denney L, Byrne AJ, Saglani S, et al., 2013, GATA3 expressing innate lymphoid cells are an important early source of Th2 cytokines driving allergen induced inflammation and AHR, Annual Congress of the British-Society-for-Immunology, Publisher: WILEY-BLACKWELL, Pages: 90-90, ISSN: 0019-2805
Mathie S, Hussell T, Lloyd C, 2013, The role of alveolar macrophages during the resolution of house dust mite induced allergic airways disease, EUROPEAN RESPIRATORY JOURNAL, Vol: 42, ISSN: 0903-1936
Byrne A, Lloyd C, Walker S, et al., 2013, Overexpression of IRF5 ameliorates house dust mite-mediated airway hyper-responsiveness via macrophage polarisation towards a classically activated phenotype, EUROPEAN RESPIRATORY JOURNAL, Vol: 42, ISSN: 0903-1936
Vasiliou J, Lui S, Sherburn R, et al., 2013, LSC 2013 abstract - Early sources of IL-13 in house dust mite-induced neonatal allergic airways disease, EUROPEAN RESPIRATORY JOURNAL, Vol: 42, ISSN: 0903-1936
Vasiliou J, Lui S, Sherburn R, et al., 2013, LSC 2013 abstract - Early sources of IL-13 in house dust mite-induced neonatal allergic airways disease, EUROPEAN RESPIRATORY JOURNAL, Vol: 42, ISSN: 0903-1936
Sherburn R, Saglani S, Vasiliou J, et al., 2013, Age of first allergen exposure is critical in determining the development of allergic airway disease, EUROPEAN RESPIRATORY JOURNAL, Vol: 42, ISSN: 0903-1936
Saglani S, Lui S, Ullmann N, et al., 2013, IL-33 promotes airway remodeling in pediatric patients with severe steroid-resistant asthma, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 132, Pages: 676-+, ISSN: 0091-6749
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- Citations: 200
Cullinan P, Lloyd C, 2013, The double macchiato years; awards for the best basic science and epidemiology papers in 2012, THORAX, Vol: 68, Pages: 777-779, ISSN: 0040-6376
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- Citations: 1
Lloyd CM, Saglani S, 2013, Eosinophils in the spotlight Finding the link between obesity and asthma, NATURE MEDICINE, Vol: 19, Pages: 976-977, ISSN: 1078-8956
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- Citations: 26
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