Publications
301 results found
Rankin SM, Lloyd CM, Pitchford SC, et al., 2009, CXCR2 mediates the recruitment of endothelial progenitor cells during allergic airways remodeling, Stem cells, Vol: 12, Pages: 3074-3081
Lloyd CM, Hawrylowicz CM, 2009, Regulatory T Cells in Asthma, IMMUNITY, Vol: 31, Pages: 438-449, ISSN: 1074-7613
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- Citations: 260
Saglani S, Mathie SA, Gregory LG, et al., 2009, Pathophysiological Features of Asthma Develop in Parallel in House Dust Mite-Exposed Neonatal Mice, AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, Vol: 41, Pages: 281-289, ISSN: 1044-1549
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- Citations: 75
Kariyawasam HH, Pegorier S, Barkans J, et al., 2009, Activin and transforming growth factor-β signaling pathways are activated after allergen challenge in mild asthma, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 124, Pages: 454-462, ISSN: 0091-6749
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- Citations: 63
Morgan AH, Dioszeghy V, Maskrey BH, et al., 2009, Phosphatidylethanolamine-esterified Eicosanoids in the Mouse <i>TISSUE LOCALIZATION AND INFLAMMATION-DEPENDENT FORMATION IN Th-2 DISEASE</i>, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 284, Pages: 21185-21191
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- Citations: 67
Semitekolou M, Alissafi T, Aggelakopoulou M, et al., 2009, Activin-A induces regulatory T cells that suppress T helper cell immune responses and protect from allergic airway disease, JOURNAL OF EXPERIMENTAL MEDICINE, Vol: 206, Pages: 1769-1785, ISSN: 0022-1007
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- Citations: 94
Ahern D, Lloyd CM, Robinson DS, 2009, Chemokine responsiveness of CD4+CD25+regulatory and CD4+CD25-T cells from atopic and nonatopic donors, ALLERGY, Vol: 64, Pages: 1121-1129, ISSN: 0105-4538
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- Citations: 21
Campbell JD, Buckland KF, McMillan SJ, et al., 2009, Peptide immunotherapy in allergic asthma generates IL-10-dependent immunological tolerance associated with linked epitope suppression, JOURNAL OF EXPERIMENTAL MEDICINE, Vol: 206, Pages: 1535-1547, ISSN: 0022-1007
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- Citations: 168
Kearley J, Buckland KF, Mathie SA, et al., 2009, Resolution of Allergic Inflammation and Airway Hyperreactivity Is Dependent upon Disruption of the T1/ST2-IL-33 Pathway, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 179, Pages: 772-781, ISSN: 1073-449X
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- Citations: 190
Lloyd CM, 2009, Dust mites' dirty dealings in the lung, NATURE MEDICINE, Vol: 15, Pages: 366-367, ISSN: 1078-8956
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- Citations: 17
Lloyd CM, 2009, Airway Remodeling in Small Animal Models, Vol: 1, Pages: 1202-1213
Animal models have been used extensively to unravel the complexities of the many features of asthma in humans. Allergic asthma is a complex disease incorporating airway inflammation as well as changes in airway function. In addition, airway remodeling is increasingly recognized to be a serious consequence of chronic asthma. Although airway eosinophilia and changes in lung function have been modeled extensively in small rodents using a variety of protocols, the structural changes occurring in the lung have only recently been investigated. Investigators have manipulated a variety of different protocols and systems to try to mimic the main pathophysiologic features of the human disease. In this chapter the main systems that have been used to identify the immunologic and pathophysiologic mechanisms that underlie the asthma phenotype are reviewed. The recent efforts to improve models by trying to replicate the structural remodeling that occurs in the lung as a consequence of chronic allergen-driven inflammation are highlighted. The effects of different allergens as well as protocols for sensitization and challenge are discussed. The use of animal models has enabled us to highlight particular pathways and has given us the opportunity to determine the functional contribution of individual pathways to disease parameters. In addition it has been possible to manipulate disease progression to determine whether pathophysiologic features of disease are dependent on each other. © 2008 Blackwell Publishing.
Wells JW, Choy K, Lloyd CM, et al., 2009, Suppression of allergic airway inflammation and IgE responses by a class I restricted allergen peptide vaccine, MUCOSAL IMMUNOLOGY, Vol: 2, Pages: 54-62, ISSN: 1933-0219
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- Citations: 13
Tan H, Regamey N, Hilliard T, et al., 2009, EXPLORING THE PHENOTYPE OF THE LYMPHOCYTIC INFILTRATE IN THE CF AIRWAY: DO IL17+CELLS PLAY A ROLE IN DISEASE PATHOGENESIS?, PEDIATRIC PULMONOLOGY, Pages: 254-254, ISSN: 8755-6863
Kell SA, Campbell JD, Trivedi SG, et al., 2009, CD154/Intracellular Cytokine Staining of Antigen-Specific T Cell Responses Functions as a Biomarker for Immunostimulatory DNA Sequence (ISS)-Induced Disease Modification in a Chronic Mouse Asthma Model., AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 179, ISSN: 1073-449X
Kearley J, Erjefalt J, Andersson C, et al., 2009, A Central Role for IL-9 in Mediating Mast Cell Progenitor Mobilization to the Lung and Chronic Remodeling of the Airways., AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 179, ISSN: 1073-449X
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- Citations: 1
Causton B, Gregory LG, Bell MJ, et al., 2008, Signalling via TLR-4 is not essential for development of HDM-induced allergic airway disease, Annual Congress of the British-Society-of-Immunology, Publisher: WILEY-BLACKWELL PUBLISHING, INC, Pages: 114-114, ISSN: 0019-2805
Murdoch JR, Lloyd CM, 2008, γδ T-cells and IL-17 regulate allergic airway inflammation and airway hyper-responsiveness, Annual Congress of the British-Society-of-Immunology, Publisher: WILEY-BLACKWELL PUBLISHING, INC, Pages: 28-29, ISSN: 0019-2805
Buckland KF, Hussell T, Lloyd CN, 2008, Development of a model of viral-induced exacerbation of allergic airways disease, Annual Congress of the British-Society-of-Immunology, Publisher: WILEY-BLACKWELL PUBLISHING, INC, Pages: 105-105, ISSN: 0019-2805
Leggat JA, Gibbons DL, Haque SFY, et al., 2008, Innate responsiveness of CD8 memory T-cell populations nonspecifically inhibits allergic sensitization, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 122, Pages: 1014-1021, ISSN: 0091-6749
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- Citations: 22
Kearley J, Robinson DS, Lloyd CM, 2008, CD4<SUP>+</SUP>CD25<SUP>+</SUP> regulatory T cells reverse established allergic airway inflammation and prevent airway remodeling, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 122, Pages: 617-624, ISSN: 0091-6749
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- Citations: 153
Tourdot S, Mathie S, Hussell T, et al., 2008, Respiratory syncytial virus infection provokes airway remodelling in allergen-exposed mice in absence of prior allergen sensitization (vol 38, pg 1016, 2008), CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 38, Pages: 1241-1241, ISSN: 0954-7894
Francis JN, Sabroe I, Lloyd CM, et al., 2008, Elevated CCR6<SUP>+</SUP> CD4<SUP>+</SUP> T lymphocytes in tissue compared with blood and induction of CCL20 during the asthmatic late response, CLINICAL AND EXPERIMENTAL IMMUNOLOGY, Vol: 152, Pages: 440-447, ISSN: 0009-9104
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- Citations: 26
Tourdot S, Mathie S, Hussell T, et al., 2008, Respiratory syncytial virus infection provokes airway remodelling in allergen-exposed mice in absence of prior allergen sensitization, CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 38, Pages: 1016-1024, ISSN: 0954-7894
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- Citations: 43
Bartlett NW, Walton RP, Edwards MR, et al., 2008, Mouse models of rhinovirus-induced disease and exacerbation of allergic airway inflammation, NATURE MEDICINE, Vol: 14, Pages: 199-204, ISSN: 1078-8956
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- Citations: 285
Semitekolou M, Alissafi T, Lloyd MC, et al., 2008, Activin A suppresses Th effector responses through induction of IL-10 and exerts anti-inflammatory role in allergic airway disease, 27th Congress of the European-Academy-of-Allergology-and-Clinical-Immunology, Publisher: BLACKWELL PUBLISHING, Pages: 337-337, ISSN: 0105-4538
Kearley J, McMillan SJ, Lloyd CM, 2007, Th2-driven, allergen-induced airway inflammation is reduced after treatment with anti-Tim-3 antibody in vivo, JOURNAL OF EXPERIMENTAL MEDICINE, Vol: 204, Pages: 1289-1294, ISSN: 0022-1007
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- Citations: 55
Lloyd CM, 2007, Building better mouse models of asthma, CURRENT ALLERGY AND ASTHMA REPORTS, Vol: 7, Pages: 231-236, ISSN: 1529-7322
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- Citations: 39
Trivedi SG, Lloyd CM, 2007, Eosinophils in the pathogenesis of allergic airways disease, CELLULAR AND MOLECULAR LIFE SCIENCES, Vol: 64, Pages: 1269-1289, ISSN: 1420-682X
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- Citations: 104
Xanthou G, Alissafi T, Semitekolou M, et al., 2007, Osteopontin has a crucial role in allergic airway disease through regulation of dendritic cell subsets, NATURE MEDICINE, Vol: 13, Pages: 570-578, ISSN: 1078-8956
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- Citations: 152
Lloyd CM, Robinson DS, 2007, Allergen-induced airway remodelling, EUROPEAN RESPIRATORY JOURNAL, Vol: 29, Pages: 1020-1032, ISSN: 0903-1936
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- Citations: 60
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