Publications
300 results found
Schuttelkopf AW, Andersen OA, Rao FV, et al., 2006, Screening-based discovery and structural dissection of a novel family 18 chitinase inhibitor, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 281, Pages: 27278-27285
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- Citations: 49
Kearley J, Robinson DS, Lloyd CM, 2006, Therapeutic administration of allergen-specific CD4<SUP>+</SUP>CD25<SUP>+</SUP> regulatory T cells suppresses chronic allergen-induced airway inflammation and remodelling in a murine model, 62nd Annual Meeting of the American-Academy-of-Allergy-Asthma-and-Immunology, Publisher: MOSBY, INC, Pages: S84-S84, ISSN: 0091-6749
Martins SC, Nouri-Aria KT, Banfield GK, et al., 2006, Allergen-induced late cutaneous responses are associated with elevated CD3<SUP>+</SUP>CCR4<SUP>+</SUP> cells and no change in CD3<SUP>+</SUP>CCR3<SUP>+</SUP> or CD3<SUP>+</SUP>CCR8<SUP>+</SUP> cells, 62nd Annual Meeting of the American-Academy-of-Allergy-Asthma-and-Immunology, Publisher: MOSBY, INC, Pages: S282-S282, ISSN: 0091-6749
Campbell D, Gronlund H, van Hage-Hamsten M, et al., 2006, Peptide immunotherapy in Fel d 1-sensitized HLA-DR1 transgenic mice is associated with increased IL-10 but independent of TGFbeta and Foxp3 expression, 62nd Annual Meeting of the American-Academy-of-Allergy-Asthma-and-Immunology, Publisher: MOSBY, INC, Pages: S327-S327, ISSN: 0091-6749
Uller L, Lloyd CM, Rydell-Törmänen K, et al., 2006, Effects of steroid treatment on lung CC chemokines, apoptosis and transepithelial cell clearance during development and resolution of allergic airway inflammation, CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 36, Pages: 111-121, ISSN: 0954-7894
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- Citations: 27
Lloyd CM, Brown Z, 2006, Chemokine receptors : therapeutic potential in asthma., Treat Respir Med, Vol: 5, Pages: 159-166, ISSN: 1176-3450
Leukocyte infiltration of the lung is a characteristic feature of allergic asthma and it is thought that these cells are selectively recruited by chemokines. Extensive research has confirmed that chemokine receptors are expressed on the main cell types involved in asthma, including eosinophils, T helper type 2 cells, mast cells and even neutrophils. Moreover, animal experiments have outlined a functional role for these receptors and their ligands. Chemokines signal via seven-transmembrane spanning G-protein coupled receptors, which are favored targets of the pharmaceutical industry due to the possibility of designing small-molecule inhibitors. In fact, this family represents the first group of cytokines where small-molecule inhibitors have been designed. However, the search for efficient antagonists of chemokine/chemokine receptors has not been easy; a particular feature of the chemokine system is the number of molecules with overlapping functions and binding specificities, as well as the difficulty in reconciling the in vivo biologic functional validation of chemokines in rodent models with the development of antagonists which bind the human receptor, because of the lack of species cross-reactivity. The chemokines and their receptors that are active during allergic reactions are reviewed. Possible points of interaction that may be a target for development of new therapies, as well as the progress to date in developing inhibitors of key chemokine receptors for asthma therapy, are also discussed.
Kearley J, Barker JE, Robinson DS, et al., 2005, Resolution of airway inflammation and hyperreactivity after in vivo transfer of CD4<SUP>+</SUP> CD25<SUP>+</SUP> regulatory T cells is interleukin 10 dependent, JOURNAL OF EXPERIMENTAL MEDICINE, Vol: 202, Pages: 1539-1547, ISSN: 0022-1007
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- Citations: 408
Kearley J, Robinson DS, Lloyd CM, 2005, Suppression of allergen-induced airway inflammation by allergen-specific CD4<SUP>+</SUP>CD25<SUP>+</SUP> regulatory T cells is IL-10 dependent, IMMUNOLOGY, Vol: 116, Pages: 14-14, ISSN: 0019-2805
Lloyd CM, 2005, Airway remodelling in asthma, IMMUNOLOGY, Vol: 116, Pages: 52-53, ISSN: 0019-2805
Bell MJ, Freeman M, Connor P, et al., 2005, Changes in lung function and remodelling following prolonged allergen exposure in mice, IMMUNOLOGY, Vol: 116, Pages: 53-53, ISSN: 0019-2805
Tourdot S, Hussell T, Openshaw PJM, et al., 2005, RSV infection provokes airway remodelling in non-sensitised allergen challenged mice, IMMUNOLOGY, Vol: 116, Pages: 53-53, ISSN: 0019-2805
Furukido K, Banfield GK, Nouri-Aria KT, et al., 2005, Allergen-induced late nasal responses are associated with an increase in CCR4 (mRNA & protein) expression in atopic subjects, Annual Meeting of the British-Society-for-Allergy-and-Clinical-Immunology, Publisher: BLACKWELL PUBLISHING, Pages: 1412-1412, ISSN: 0954-7894
Martins SC, Banfield GK, Watanabe H, et al., 2005, CCR4 and CXCR3 on CD3<SUP>+</SUP> cells in the skin following allergen and PPD challenge in atopics and non-atopic individuals, Annual Meeting of the British-Society-for-Allergy-and-Clinical-Immunology, Publisher: BLACKWELL PUBLISHING, Pages: 1410-1411, ISSN: 0954-7894
McMillan SJ, Xanthou G, Lloyd CM, 2005, Manipulation of allergen-induced airway remodeling by treatment with anti-TGF-β antibody:: Effect on the Smad signaling pathway, JOURNAL OF IMMUNOLOGY, Vol: 174, Pages: 5774-5780, ISSN: 0022-1767
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- Citations: 219
McMillan SJ, Xanthou G, Lloyd CM, 2005, Therapeutic administration of Budesonide ameliorates allergen-induced airway remodelling, CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 35, Pages: 388-396, ISSN: 0954-7894
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- Citations: 54
Humbles AA, LLoyd CM, McMillan SJ, et al., 2004, A critical role for eosinophils in allergic airways remodeling, Science, Vol: 305, Pages: 1776-1779, ISSN: 0036-8075
Mcmillan SJ, Lloyd CM, 2004, Prolonged allergen challenge in mice leads to persistent airway remodelling, CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 34, Pages: 497-507, ISSN: 0954-7894
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- Citations: 184
McMillan SJ, Kearley J, Campbell JD, et al., 2004, Matrix metalloproteinase-9 deficiency results in enhanced allergen-induced airway inflammation, JOURNAL OF IMMUNOLOGY, Vol: 172, Pages: 2586-2594, ISSN: 0022-1767
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- Citations: 145
Francis JN, Jacobson MR, Lloyd CM, et al., 2004, CXCR1<SUP>+</SUP>CD4<SUP>+</SUP> T cells in human allergic disease, JOURNAL OF IMMUNOLOGY, Vol: 172, Pages: 268-273, ISSN: 0022-1767
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- Citations: 16
Lloyd CM, Robinson DS, McMillan SJ, 2004, Modelling airway remodelling in asthma, Drug Discovery Today: Disease Models, Vol: 1, Pages: 425-430, ISSN: 1740-6757
Airway remodelling is increasingly recognised to be a serious consequence of chronic asthma. Although the acute inflammation associated with asthma has been modelled extensively both in vitro and in vivo, the structural changes occurring in the lung have only recently been investigated. Here, we review the recent advances in systems designed to examine the pathways leading to allergen induced airway remodelling. © 2004 Elsevier Ltd. All rights reserved.
Lloyd CM, Gutierrez-Ramos J-C, 2004, Animal models to study chemokine receptor function: in vivo mouse models of allergic airway inflammation., Methods Mol Biol, Vol: 239, Pages: 199-210, ISSN: 1064-3745
Banwell ME, Robinson DS, Lloyd CM, 2003, Adenoid-derived T<sub>H</sub>2 cells reactive to allergen and recall antigen express CC chemokine receptor 4, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 112, Pages: 1155-1161, ISSN: 0091-6749
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- Citations: 13
Conroy DM, Jopling LA, Lloyd CM, et al., 2003, CCR4 blockade does not inhibit allergic airways inflammation, JOURNAL OF LEUKOCYTE BIOLOGY, Vol: 74, Pages: 558-563, ISSN: 0741-5400
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- Citations: 48
Lloyd CM, Rankin SM, 2003, Chemokines in allergic airway disease, CURRENT OPINION IN PHARMACOLOGY, Vol: 3, Pages: 443-448, ISSN: 1471-4892
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- Citations: 59
Bishop B, Lloyd CM, 2003, CC chemokine ligand 1 promotes recruitment of eosinophils but not Th2 cells during the development of allergic airways disease, JOURNAL OF IMMUNOLOGY, Vol: 170, Pages: 4810-4817, ISSN: 0022-1767
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- Citations: 50
Nouri-Aria KT, Wilson D, Francis JN, et al., 2002, CCR4 in human allergen-induced late responses in the skin and lung, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 32, Pages: 1933-1938, ISSN: 0014-2980
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- Citations: 54
Robinson DS, Lloyd CM, 2002, Asthma: T-bet - A master controller?, CURRENT BIOLOGY, Vol: 12, Pages: R322-R324, ISSN: 0960-9822
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- Citations: 36
Sabroe I, Lloyd CM, Whyte MKB, et al., 2002, Chemokines, innate and adaptive immunity, and respiratory disease, EUROPEAN RESPIRATORY JOURNAL, Vol: 19, Pages: 350-355, ISSN: 0903-1936
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- Citations: 48
Lloyd C, 2002, Chemokines in allergic lung inflammation, IMMUNOLOGY, Vol: 105, Pages: 144-154, ISSN: 0019-2805
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- Citations: 59
McMillan S, Bishop B, Townsend MJ, et al., 2002, The absence of interleukin 9 does not affect the development of allergen-induced pulmonary inflammation nor airway hyperreactivity, JOURNAL OF EXPERIMENTAL MEDICINE, Vol: 195, Pages: 51-57, ISSN: 0022-1007
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- Citations: 112
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