ProfessorCristinaLo Celso

Faculty of Natural Sciences, Department of Life Sciences

Co-Director Centre for Haematology & Prof Stem Cell Biology

Contact

c.lo-celso

Location

548Sir Alexander Fleming BuildingSouth Kensington Campus

Summary

For more information on the lab, including details of any open position, visit our group website here.

Research

Dr Lo Celso’s work focuses on the dynamic processes underlying healthy and malignant haematopoiesis, using an interdisciplinary approach that combines advanced intravital microscopy, computational image analysis, flow cytometry and mathematical modelling.

Video placeholder image — 14 hours long time lapse of a T cell acute lymphoblastic leukaemia (T-ALL) cells observed using confocal microscopy of live mouse calvarium bone marrow. The T-ALL cell expresses DsRed fluorescent protein (red) and also visible are bone marrow vasculature (cy5 dextran, blue) and GFP-expressing osteoblastic cells (green).

Recruitment

From time to time there may be open positions to join Dr Lo Celso’s research team. These will be posted on the group website (here: link to http://www3.imperial.ac.uk/locelsolab/group). If there are no open positions but you are interested in joining the group as a postdoc or PhD student, please get in touch directly via email.

Teaching

Dr Lo Celso teaches and co-organises with Dr Anita Hall the Stem Cells, Regeneration and Ageing (SCRA) course for the 3rd year of the Biochemistry and Biology degrees. She also teaches development of the immune system and haematopoietic stem cell biology in the Immunology courses of Biochemistry and Biology degrees and cell and stem cell biology in the Cell and Developmental Biology course of the Biology degree. These are 2nd year courses.

Dr Lo Celso runs a number of tutorials for first, second and third year courses as well as the SCRA practical. She is personal tutor for the Biochemistry degree, supervises third year literature projects and accommodates third year Biochemistry laboratory projects within her research group.

Dr Lo Celso provides lectures on stem cell biology and intravital microscopy for the MSc Applied Biosciences and Biotechnology and the MSc, PG Cert Genes, Drugs and Stem Cells - Novel Therapies. She is guest lecturer at Queen Mary University in the Regenerative Medicine Msc and was faculty at the Hydra Stem Cells summer school 2016

Publications

Journals

Pirillo C, Birch F, Tissot FS, et al.Pirillo C, Birch F, Tissot FS, Anton SG, Haltalli M, Tini V, Kong I, Piot C, Partridge B, Pospori C, Keeshan K, Santamaria S, Hawkins E, Falini B, Marra A, Duarte D, Lee CF, Roberts E, Lo Celso C close, 2022, Metalloproteinase inhibition reduces AML growth, prevents stem cell loss, and improves chemotherapy effectiveness, Blood Advances, Vol:6, ISSN:2473-9529, Pages:3126-3141

Zhou L, Kong G, Palmisano I, et al.Zhou L, Kong G, Palmisano I, Cencioni MT, Danzi M, De Virgiliis F, Chadwick JS, Crawford G, Yu Z, De Winter F, Lemmon V, Bixby J, Puttagunta R, Verhaagen J, Pospori C, Lo Celso C, Strid J, Botto M, Di Giovanni S close, 2022, Reversible CD8 T cell-neuron cross-talk causes aging-dependent neuronal regenerative decline., Science, Vol:376, ISSN:0036-8075, Pages:1-15

Haltalli MLR, Lo Celso C, 2021, Intravital Imaging of Bone Marrow Niches, Bone Marrow Environment, Vol:2308, ISSN:1064-3745, Pages:203-222

Haltalli MLR, Watcham S, Wilson NK, et al.Haltalli MLR, Watcham S, Wilson NK, Eilers K, Lipien A, Ang H, Birch F, Anton SG, Pirillo C, Ruivo N, Vainieri ML, Pospori C, Sinden RE, Luis TC, Langhorne J, Duffy KR, Gottgens B, Blagborough AM, Lo Celso C close, 2020, Manipulating niche composition limits damage to haematopoietic stem cells during Plasmodium infection, Nature Cell Biology, Vol:22, ISSN:1465-7392, Pages:1399-1410

Conference

Soto CA, Lo Celso C, Purton LE, et al.Soto CA, Lo Celso C, Purton LE, Frisch BJ close, 2021, From the niche to malignant hematopoiesis and back: reciprocal interactions between leukemia and the bone marrow microenvironment, WILEY

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