Imperial College London

ProfessorCristinaLo Celso

Faculty of Natural SciencesDepartment of Life Sciences

Professor of Stem Cell Biology
 
 
 
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Contact

 

+44 (0)20 7594 5359c.lo-celso

 
 
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Location

 

550Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
to

69 results found

Carlson AL, Fujisaki J, Wu J, Runnels JM, Turcotte R, Lo Celso C, Scadden DT, Strom TB, Lin CPet al., 2013, Tracking Single Cells in Live Animals Using a Photoconvertible Near-Infrared Cell Membrane Label, PLOS ONE, Vol: 8, ISSN: 1932-6203

Journal article

Lo Celso C, 2013, IN VIVO IMAGING OF QUIESCENT AND PHYSIOLOGICALLY ACTIVATED HAEMATOPOIETIC STEM CELLS, 42nd Annual Scientific Meeting of the International-Society-for-Experimental-Hematology-and-Stem-Cells (ISEH), Publisher: ELSEVIER SCIENCE INC, Pages: S4-S4, ISSN: 0301-472X

Conference paper

Roeder I, Krinner A, Scherf N, Scott M, Rashidi N, Pompe T, Lo Celso Cet al., 2013, QUANTIFICATION OF STEM CELL/NICHE INTERACTIONS BY COUPLING IN VIVO IMAGING AND IN SILICO SIMULATION, 42nd Annual Scientific Meeting of the International-Society-for-Experimental-Hematology-and-Stem-Cells (ISEH), Publisher: ELSEVIER SCIENCE INC, Pages: S31-S31, ISSN: 0301-472X

Conference paper

Progatzky F, Dallman MJ, Lo Celso C, 2013, From seeing to believing: labelling strategies for in vivo cell-tracking experiments, INTERFACE FOCUS, Vol: 3, ISSN: 2042-8898

Journal article

MacLean AL, Lo Celso C, Stumpf MPH, 2013, Population dynamics of normal and leukaemia stem cells in the haematopoietic stem cell niche show distinct regimes where leukaemia will be controlled, JOURNAL OF THE ROYAL SOCIETY INTERFACE, Vol: 10, ISSN: 1742-5689

Journal article

Fink J, Kent D, Li J, Hawkins E, Lo Celso C, Green Aet al., 2013, Homozygous JAK2V617F drives rapid hematopoietic stem cell proliferation and differentiation at the expense of self-renewal, Publisher: Elsevier, Pages: S15-S15

Conference paper

Sottocornola R, Lo Celso C, 2012, Dormancy in the stem cell niche, STEM CELL RESEARCH & THERAPY, Vol: 3, ISSN: 1757-6512

Journal article

Hawkins ED, Celso CL, 2012, Subdivision of bone marrow microenvironments: purpose built homes for haematopoietic stem cells, The EMBO Journal

Journal article

Barrett O, Sottocornola R, Lo Celso C, 2012, In vivo imaging of hematopoietic stem cells in the bone marrow niche., Methods Mol Biol, Vol: 916, Pages: 231-242

Even though hematopoietic stem cells (HSC) are amongst the first somatic stem cells exploited for therapeutic purposes, their application is still limited by the inability to expand them ex vivo without impairing their function. Moreover, it has recently emerged that several types of leukemia develop and relapse through complex interactions with bone marrow (BM) components and may directly affect the HSC and their niche. Increasing attention has therefore been dedicated to the BM microenvironment the HSC reside in, with the view that a better understanding of the molecular regulators of HSC-niche interaction in vivo will allow improving HSC mobilization, collection and transplantation and provide clues for the development of innovative leukemia treatments. This chapter focuses on a recently established technique for the visualization of transplanted hematopoietic stem and progenitor cells (HSPC) within the calvarium bone marrow of live mice (Lo Celso et al. Nature 457:92-96, 2007). Intravital microscopy is a rapidly developing field, driven by constant improvement in both detection technologies (i.e., spatial resolution, depth of penetration, spectral definition) and probe availability (i.e., increasingly sophisticated genetic and chemical reporter systems). We therefore discuss the current limitations and challenges related to intravital microscopy of the HSC niche and introduce a number of potential imaging approaches, which could be promising candidates for future development of this technique.

Journal article

Strydom N, Lo Celso C, Scott M, Rankin Set al., 2011, Using intravital microscopy to investigate the molecules that regulate the homing of senescent neutrophils to the bone marrow and their phagocytosis by bone marrow macrophages, Annual Congress of the British-Society-for-Immunology, Publisher: WILEY-BLACKWELL, Pages: 127-127, ISSN: 0019-2805

Conference paper

Silberstein L, Osawa M, Lin C, Kharchenko P, Lo Celso C, Aribeana C, Scadden DTet al., 2011, Real-Time RT-PCR Analysis of Individual Osteolineage Cells within the Hematopoietic Stem Cell Niche, 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis, Publisher: AMER SOC HEMATOLOGY, Pages: 1028-1029, ISSN: 0006-4971

Conference paper

Lo Celso C, Scadden DT, 2011, The haematopoietic stem cell niche at a glance, JOURNAL OF CELL SCIENCE, Vol: 124, Pages: 3529-3535, ISSN: 0021-9533

Journal article

Lane SW, Wang YJ, Lo Celso C, Ragu C, Bullinger L, Sykes SM, Ferraro F, Shterental S, Lin CP, Gilliland DG, Scadden DT, Armstrong SA, Williams DAet al., 2011, Differential niche and Wnt requirements during acute myeloid leukemia progression, BLOOD, Vol: 118, Pages: 2849-2856, ISSN: 0006-4971

Journal article

Cornejo MG, Mabialah V, Sykes SM, Khandan T, Lo Celso C, Lopez CK, Rivera-Munoz P, Rameau P, Tothova Z, Aster JC, DePinho RA, Scadden DT, Gilliland DG, Mercher Tet al., 2011, Crosstalk between NOTCH and AKT signaling during murine megakaryocyte lineage specification, BLOOD, Vol: 118, Pages: 1264-1273, ISSN: 0006-4971

Journal article

Rodriguez S, Wang L, Mumaw C, Srour EF, Lo Celso C, Nakayama K-I, Carlesso Net al., 2011, The SKP2 E3 ligase regulates basal homeostasis and stress-induced regeneration of HSCs, BLOOD, Vol: 117, Pages: 6509-6519, ISSN: 0006-4971

Journal article

Fujisaki J, Wu J, Carlson AL, Silberstein L, Putheti P, Larocca R, Gao W, Saito TI, Lo Celso C, Tsuyuzaki H, Sato T, Cote D, Sykes M, Strom TB, Scadden DT, Lin CPet al., 2011, In vivo imaging of T-reg cells providing immune privilege to the haematopoietic stem-cell niche, NATURE, Vol: 474, Pages: 216-U256, ISSN: 0028-0836

Journal article

Sanchez-Aguilera A, Lee Y-J, Lo Celso C, Ferraro F, Brumme K, Mondal S, Kim C, Dorrance A, Luo HR, Scadden DT, Williams DAet al., 2011, Guanine nucleotide exchange factor Vav1 regulates perivascular homing and bone marrow retention of hematopoietic stem and progenitor cells, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 108, Pages: 9607-9612, ISSN: 0027-8424

Journal article

Lo Celso C, Lin CP, Scadden DT, 2011, In vivo imaging of transplanted hematopoietic stem and progenitor cells in mouse calvarium bone marrow, NATURE PROTOCOLS, Vol: 6, Pages: 1-14, ISSN: 1754-2189

Journal article

Sanchez-Aguilera A, Lee Y-J, Lo Celso C, Ferraro F, Brumme K, Mondal S, Kim C, Adrienne D, Luo HR, Scadden DT, Williams DAet al., 2010, Vav1 Regulates Perivascular Homing, Bone Marrow Retention and Engraftment of Hematopoietic Stem Cells Via SDF1a Signaling, 52nd Annual Meeting of the American-Society-of-Hematology (ASH), Publisher: AMER SOC HEMATOLOGY, Pages: 179-179, ISSN: 0006-4971

Conference paper

Lane SW, Sykes SM, Ferraro F, Lin CP, Gilliland DG, Williams DA, Scadden DT, Lo Celso Cet al., 2010, LEUKEMIA STEM CELLS OCCUPY NICHES THAT ARE PHYSICALLY DISTINCT AND INDEPENDENT OF THE NORMAL CONSTRAINTS THAT APPLY TO HEMATOPOIETIC STEM CELLS, 39th Annual Scientific Meeting of the ISEH - Society-for-Hematology-and-Stem-Cells, Publisher: ELSEVIER SCIENCE INC, Pages: S38-S38, ISSN: 0301-472X

Conference paper

Lane SW, Sykes SM, Al-Shahrour F, Shterental S, Paktinat M, Lo Celso C, Jesneck JL, Ebert BL, Williams DA, Gilliland DGet al., 2010, The Apc(min) mouse has altered hematopoietic stem cell function and provides a model for MPD/MDS., Blood, Vol: 115, Pages: 3489-3497

Apc, a negative regulator of the canonical Wnt signaling pathway, is a bona-fide tumor suppressor whose loss of function results in intestinal polyposis. APC is located in a commonly deleted region on human chromosome 5q, associated with myelodysplastic syndrome (MDS), suggesting that haploinsufficiency of APC contributes to the MDS phenotype. Analysis of the hematopoietic system of mice with the Apc(min) allele that results in a premature stop codon and loss of function showed no abnormality in steady state hematopoiesis. Bone marrow derived from Apc(min) mice showed enhanced repopulation potential, indicating a cell intrinsic gain of function in the long-term hematopoietic stem cell (HSC) population. However, Apc(min) bone marrow was unable to repopulate secondary recipients because of loss of the quiescent HSC population. Apc(min) mice developed a MDS/myeloproliferative phenotype. Our data indicate that Wnt activation through haploinsufficiency of Apc causes insidious loss of HSC function that is only evident in serial transplantation strategies. These data provide a cautionary note for HSC-expansion strategies through Wnt pathway activation, provide evidence that cell extrinsic factors can contribute to the development of myeloid disease, and indicate that loss of function of APC may contribute to the phenotype observed in patients with MDS and del(5q).

Journal article

Lo Celso C, 2010, Every cloud has a silver lining, BLOOD, Vol: 115, Pages: 438-439, ISSN: 0006-4971

Journal article

Ferraro F, Lo Celso C, Scadden D, 2010, ADULT STEM CELLS AND THEIR NICHES, CELL BIOLOGY OF STEM CELLS, Vol: 695, Pages: 155-168, ISSN: 0065-2598

Journal article

Lo Celso C, Wu JW, Lin CP, 2009, In vivo imaging of hematopoietic stem cells and their microenvironment, JOURNAL OF BIOPHOTONICS, Vol: 2, Pages: 619-631, ISSN: 1864-063X

Journal article

Adams GB, Alley IR, Chung U-I, Chabner KT, Jeanson NT, Lo Celso C, Marsters ES, Chen M, Weinstein LS, Lin CP, Kronenberg HM, Scadden DTet al., 2009, Haematopoietic stem cells depend on G alpha(s)-mediated signalling to engraft bone marrow, NATURE, Vol: 459, Pages: 103-U111, ISSN: 0028-0836

Journal article

Lo Celso C, Fleming HE, Wu JW, Zhao CX, Miake-Lye S, Fujisaki J, Cote D, Rowe DW, Lin CP, Scadden DTet al., 2009, Live-animal tracking of individual haematopoietic stem/progenitor cells in their niche, NATURE, Vol: 457, Pages: 92-U96, ISSN: 0028-0836

Journal article

Szotek PP, Chang HL, Brennand K, Fujino A, Pieretti-Vanmarcke R, Lo Celso C, Dombkowski D, Preffer F, Cohen KS, Teixeira J, Donahoe PKet al., 2008, Normal ovarian surface epithelial label-retaining cells exhibit stem/progenitor cell characteristics, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 105, Pages: 12469-12473, ISSN: 0027-8424

Journal article

Janzen V, Fleming HE, Riedt T, Karlsson G, Riese MJ, Lo Celso C, Reynolds G, Milne CD, Paige CJ, Karlsson S, Woo M, Scadden DTet al., 2008, Hematopoietic stem cell responsiveness to exogenous signals is limited by Caspase-3, CELL STEM CELL, Vol: 2, Pages: 584-594, ISSN: 1934-5909

Journal article

Lo Celso C, Berta MA, Braun KM, Frye M, Lyle S, Zouboulis CC, Watt FMet al., 2008, Characterization of bipotential epidermal progenitors derived from human sebaceous gland: Contrasting roles of c-Myc and beta-catenin, STEM CELLS, Vol: 26, Pages: 1241-1252, ISSN: 1066-5099

Journal article

Fleming HE, Janzen V, Lo Celso C, Guo J, Leahy KM, Kronenberg HM, Scadden DTet al., 2008, Wnt signaling in the niche enforces hematopoietic stem cell quiescence and is necessary to preserve self-renewal in vivo, CELL STEM CELL, Vol: 2, Pages: 274-283, ISSN: 1934-5909

Journal article

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