Imperial College London

ProfessorCristinaLo Celso

Faculty of Natural SciencesDepartment of Life Sciences

Professor of Stem Cell Biology
 
 
 
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Contact

 

+44 (0)20 7594 5359c.lo-celso

 
 
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Location

 

550Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
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69 results found

Lo Celso C, Klein RJ, Scadden DT, 2007, Analysis of the hematopoietic stem cell niche., Curr Protoc Stem Cell Biol, Vol: Chapter 2, Pages: Unit-2A.5

Hematopoietic stem cells (HSCs) continuously replenish all blood cell lineages not only to maintain the normal rapid turnover of differentiated cells but also to respond to injury and stress. Cell-extrinsic mechanisms are critical determinants of the fine balance between HSC self-renewal and differentiation. The bone marrow microenvironment has emerged as a new area of intense study to identify which of its many components constitute the HSC niche and regulate HSC fate. While HSCs have been isolated, characterized and used in clinical practice for many years thanks to the development of very specific assays and technology (i.e., bone marrow transplants and fluorescence activated cell sorting), study of the HSC niche has evolved by combining experimental designs developed in different fields. In this unit we describe a collection of protocols spanning a wide range of techniques that can help every researcher tackling questions regarding the nature of the HSC niche.

Journal article

Lo Celso C, Scadden DT, 2007, Stem cells remember their grade, CELL STEM CELL, Vol: 1, Pages: 132-134, ISSN: 1934-5909

Journal article

Lo Celso C, Scadden D, 2007, Isolation and transplantation of hematopoietic stem cells (HSCs)., J Vis Exp

Journal article

Estrach S, Ambler CA, Lo Celso C, Hozumi K, Watt FMet al., 2006, Jagged 1 is a beta-catenin target gene required for ectopic hair follicle formation in adult epidermis, DEVELOPMENT, Vol: 133, Pages: 4427-4438, ISSN: 0950-1991

Journal article

Morita K, Lo Celso C, Spencer-Dene B, Zouboulis CC, Watt FMet al., 2006, HAN11 binds mDia1 and controls GLI1 transcriptional activity, JOURNAL OF DERMATOLOGICAL SCIENCE, Vol: 44, Pages: 11-20, ISSN: 0923-1811

Journal article

Watt FM, Lo Celso C, Silva-Vargas V, 2006, Epidermal stem cells: an update, CURRENT OPINION IN GENETICS & DEVELOPMENT, Vol: 16, Pages: 518-524, ISSN: 0959-437X

Journal article

Silva-Vargas V, Lo Celso C, Giangreco A, Ofstad T, Prowse DM, Braun KM, Watt FMet al., 2005, beta-catenin and hedgehog signal strength can specify number and location of hair follicles in adult epidermis without recruitment of bulge stem cells, DEVELOPMENTAL CELL, Vol: 9, Pages: 121-131, ISSN: 1534-5807

Journal article

Medico E, Gentile A, Lo Celso C, Williams TA, Gambarotta G, Trusolino L, Comoglio PMet al., 2001, Osteopontin is an autocrine mediator of hepatocyte growth factor-induced invasive growth, CANCER RESEARCH, Vol: 61, Pages: 5861-5868, ISSN: 0008-5472

Journal article

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