69 results found
Lo Celso C, Klein RJ, Scadden DT, 2007, Analysis of the hematopoietic stem cell niche., Curr Protoc Stem Cell Biol, Vol: Chapter 2, Pages: Unit-2A.5
Hematopoietic stem cells (HSCs) continuously replenish all blood cell lineages not only to maintain the normal rapid turnover of differentiated cells but also to respond to injury and stress. Cell-extrinsic mechanisms are critical determinants of the fine balance between HSC self-renewal and differentiation. The bone marrow microenvironment has emerged as a new area of intense study to identify which of its many components constitute the HSC niche and regulate HSC fate. While HSCs have been isolated, characterized and used in clinical practice for many years thanks to the development of very specific assays and technology (i.e., bone marrow transplants and fluorescence activated cell sorting), study of the HSC niche has evolved by combining experimental designs developed in different fields. In this unit we describe a collection of protocols spanning a wide range of techniques that can help every researcher tackling questions regarding the nature of the HSC niche.
Lo Celso C, Scadden DT, 2007, Stem cells remember their grade, CELL STEM CELL, Vol: 1, Pages: 132-134, ISSN: 1934-5909
Lo Celso C, Scadden D, 2007, Isolation and transplantation of hematopoietic stem cells (HSCs)., J Vis Exp
Estrach S, Ambler CA, Lo Celso C, et al., 2006, Jagged 1 is a beta-catenin target gene required for ectopic hair follicle formation in adult epidermis, DEVELOPMENT, Vol: 133, Pages: 4427-4438, ISSN: 0950-1991
Morita K, Lo Celso C, Spencer-Dene B, et al., 2006, HAN11 binds mDia1 and controls GLI1 transcriptional activity, JOURNAL OF DERMATOLOGICAL SCIENCE, Vol: 44, Pages: 11-20, ISSN: 0923-1811
Watt FM, Lo Celso C, Silva-Vargas V, 2006, Epidermal stem cells: an update, CURRENT OPINION IN GENETICS & DEVELOPMENT, Vol: 16, Pages: 518-524, ISSN: 0959-437X
Silva-Vargas V, Lo Celso C, Giangreco A, et al., 2005, beta-catenin and hedgehog signal strength can specify number and location of hair follicles in adult epidermis without recruitment of bulge stem cells, DEVELOPMENTAL CELL, Vol: 9, Pages: 121-131, ISSN: 1534-5807
Lo Celso C, Prowse DM, Watt FM, 2004, Transient activation of beta-catenin signalling in adult mouse epidermis is sufficient to induce new hair follicles but continuous activation is required to maintain hair follicle tumours, DEVELOPMENT, Vol: 131, Pages: 1787-1799, ISSN: 0950-1991
Medico E, Gentile A, Lo Celso C, et al., 2001, Osteopontin is an autocrine mediator of hepatocyte growth factor-induced invasive growth, CANCER RESEARCH, Vol: 61, Pages: 5861-5868, ISSN: 0008-5472
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