Imperial College London

ProfessorCristinaLo Celso

Faculty of Natural SciencesDepartment of Life Sciences

Professor of Stem Cell Biology
 
 
 
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Contact

 

+44 (0)20 7594 5359c.lo-celso

 
 
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Location

 

550Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@inproceedings{Khorshed:2016:10.1109/ISBI.2016.7493485,
author = {Khorshed, R and Lo, Celso C},
doi = {10.1109/ISBI.2016.7493485},
publisher = {IEEE},
title = {Machine learning classification of complex vasculature structures from in vivo bone marrow 3D data},
url = {http://dx.doi.org/10.1109/ISBI.2016.7493485},
year = {2016}
}

RIS format (EndNote, RefMan)

TY  - CPAPER
AB - Blood vessels inside the bone marrow (BM) play a vital role in the maintenance of hematopoietic stem cell (HSCs). Investigating the interaction of HSCs relative to vasculature has become the main headline for many recent studies. Advances in microscopy and image analysis using mouse models have allowed detection, identification and automated quantification of HSCs alongside their vascular niche. This resulted in new hypotheses concerning the activation state of HSCs adjacent to different blood vessel types (for example sinusoids vs. arterioles). Identifying the different types of BM vasculature has become critically important, however it still requires the use of complex immunostainings ex vivo or transgenic reporter mouse lines in vivo. To eliminate these requirements and increase the throughput of studies focusing on the HSC niche, we present a machine learning classification approach based on the Decision Tree Classifier to classify different regions of bone marrow vasculature into four distinct classes based on their discriminative features.
AU - Khorshed,R
AU - Lo,Celso C
DO - 10.1109/ISBI.2016.7493485
PB - IEEE
PY - 2016///
SN - 1945-8452
TI - Machine learning classification of complex vasculature structures from in vivo bone marrow 3D data
UR - http://dx.doi.org/10.1109/ISBI.2016.7493485
UR - http://hdl.handle.net/10044/1/45828
ER -