Publications
90 results found
Strydom N, Lo Celso C, Scott M, et al., 2011, Using intravital microscopy to investigate the molecules that regulate the homing of senescent neutrophils to the bone marrow and their phagocytosis by bone marrow macrophages, Annual Congress of the British-Society-for-Immunology, Publisher: WILEY-BLACKWELL, Pages: 127-127, ISSN: 0019-2805
Silberstein L, Osawa M, Lin C, et al., 2011, Real-Time RT-PCR Analysis of Individual Osteolineage Cells within the Hematopoietic Stem Cell Niche, 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis, Publisher: AMER SOC HEMATOLOGY, Pages: 1028-1029, ISSN: 0006-4971
Lo Celso C, Scadden DT, 2011, The haematopoietic stem cell niche at a glance, JOURNAL OF CELL SCIENCE, Vol: 124, Pages: 3529-3535, ISSN: 0021-9533
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- Citations: 91
Lane SW, Wang YJ, Lo Celso C, et al., 2011, Differential niche and Wnt requirements during acute myeloid leukemia progression, BLOOD, Vol: 118, Pages: 2849-2856, ISSN: 0006-4971
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- Citations: 119
Cornejo MG, Mabialah V, Sykes SM, et al., 2011, Crosstalk between NOTCH and AKT signaling during murine megakaryocyte lineage specification, BLOOD, Vol: 118, Pages: 1264-1273, ISSN: 0006-4971
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- Citations: 56
Rodriguez S, Wang L, Mumaw C, et al., 2011, The SKP2 E3 ligase regulates basal homeostasis and stress-induced regeneration of HSCs, BLOOD, Vol: 117, Pages: 6509-6519, ISSN: 0006-4971
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- Citations: 36
Fujisaki J, Wu J, Carlson AL, et al., 2011, <i>In vivo</i> imaging of T<sub>reg</sub> cells providing immune privilege to the haematopoietic stem-cell niche, NATURE, Vol: 474, Pages: 216-U256, ISSN: 0028-0836
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- Citations: 409
Sanchez-Aguilera A, Lee Y-J, Lo Celso C, et al., 2011, Guanine nucleotide exchange factor Vav1 regulates perivascular homing and bone marrow retention of hematopoietic stem and progenitor cells, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 108, Pages: 9607-9612, ISSN: 0027-8424
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- Citations: 28
Lo Celso C, Lin CP, Scadden DT, 2011, <i>In vivo</i> imaging of transplanted hematopoietic stem and progenitor cells in mouse calvarium bone marrow, NATURE PROTOCOLS, Vol: 6, Pages: 1-14, ISSN: 1754-2189
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- Citations: 80
Sanchez-Aguilera A, Lee Y-J, Lo Celso C, et al., 2010, Vav1 Regulates Perivascular Homing, Bone Marrow Retention and Engraftment of Hematopoietic Stem Cells Via SDF1a Signaling, 52nd Annual Meeting of the American-Society-of-Hematology (ASH), Publisher: AMER SOC HEMATOLOGY, Pages: 179-179, ISSN: 0006-4971
Lane SW, Sykes SM, Ferraro F, et al., 2010, LEUKEMIA STEM CELLS OCCUPY NICHES THAT ARE PHYSICALLY DISTINCT AND INDEPENDENT OF THE NORMAL CONSTRAINTS THAT APPLY TO HEMATOPOIETIC STEM CELLS, 39th Annual Scientific Meeting of the ISEH - Society-for-Hematology-and-Stem-Cells, Publisher: ELSEVIER SCIENCE INC, Pages: S38-S38, ISSN: 0301-472X
Lane SW, Sykes SM, Al-Shahrour F, et al., 2010, The <i>Apc<SUP>min</SUP></i> mouse has altered hematopoietic stem cell function and provides a model for MPD/MDS, BLOOD, Vol: 115, Pages: 3489-3497, ISSN: 0006-4971
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- Citations: 80
Lo Celso C, 2010, Every cloud has a silver lining, BLOOD, Vol: 115, Pages: 438-439, ISSN: 0006-4971
Ferraro F, Lo Celso C, Scadden D, 2010, ADULT STEM CELLS AND THEIR NICHES, CELL BIOLOGY OF STEM CELLS, Vol: 695, Pages: 155-168, ISSN: 0065-2598
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- Citations: 105
Lo Celso C, Wu JW, Lin CP, 2009, <i>In vivo</i> imaging of hematopoietic stem cells and their microenvironment, JOURNAL OF BIOPHOTONICS, Vol: 2, Pages: 619-631, ISSN: 1864-063X
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- Citations: 55
Adams GB, Alley IR, Chung U-I, et al., 2009, Haematopoietic stem cells depend on Gα<sub>s</sub>-mediated signalling to engraft bone marrow, NATURE, Vol: 459, Pages: 103-U111, ISSN: 0028-0836
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- Citations: 54
Lo Celso C, Fleming HE, Wu JW, et al., 2009, Live-animal tracking of individual haematopoietic stem/progenitor cells in their niche, NATURE, Vol: 457, Pages: 92-U96, ISSN: 0028-0836
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- Citations: 675
Szotek PP, Chang HL, Brennand K, et al., 2008, Normal ovarian surface epithelial label-retaining cells exhibit stem/progenitor cell characteristics, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 105, Pages: 12469-12473, ISSN: 0027-8424
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- Citations: 95
Janzen V, Fleming HE, Riedt T, et al., 2008, Hematopoietic stem cell responsiveness to exogenous signals is limited by Caspase-3, CELL STEM CELL, Vol: 2, Pages: 584-594, ISSN: 1934-5909
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- Citations: 98
Lo Celso C, Berta MA, Braun KM, et al., 2008, Characterization of bipotential epidermal progenitors derived from human sebaceous gland:: Contrasting roles of c-Myc and β-catenin, STEM CELLS, Vol: 26, Pages: 1241-1252, ISSN: 1066-5099
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- Citations: 93
Fleming HE, Janzen V, Lo Celso C, et al., 2008, Wnt signaling in the niche enforces hematopoietic stem cell quiescence and is necessary to preserve self-renewal in vivo, CELL STEM CELL, Vol: 2, Pages: 274-283, ISSN: 1934-5909
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- Citations: 387
Lo Celso C, Klein RJ, Scadden DT, 2007, Analysis of the hematopoietic stem cell niche., Curr Protoc Stem Cell Biol, Vol: Chapter 2, Pages: Unit-2A.5
Hematopoietic stem cells (HSCs) continuously replenish all blood cell lineages not only to maintain the normal rapid turnover of differentiated cells but also to respond to injury and stress. Cell-extrinsic mechanisms are critical determinants of the fine balance between HSC self-renewal and differentiation. The bone marrow microenvironment has emerged as a new area of intense study to identify which of its many components constitute the HSC niche and regulate HSC fate. While HSCs have been isolated, characterized and used in clinical practice for many years thanks to the development of very specific assays and technology (i.e., bone marrow transplants and fluorescence activated cell sorting), study of the HSC niche has evolved by combining experimental designs developed in different fields. In this unit we describe a collection of protocols spanning a wide range of techniques that can help every researcher tackling questions regarding the nature of the HSC niche.
Lo Celso C, Scadden DT, 2007, Stem cells remember their grade, CELL STEM CELL, Vol: 1, Pages: 132-134, ISSN: 1934-5909
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- Citations: 1
Lo Celso C, Scadden D, 2007, Isolation and transplantation of hematopoietic stem cells (HSCs)., J Vis Exp
Estrach S, Ambler CA, Lo Celso C, et al., 2006, Jagged 1 is a β-catenin target gene required for ectopic hair follicle formation in adult epidermis, DEVELOPMENT, Vol: 133, Pages: 4427-4438, ISSN: 0950-1991
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- Citations: 187
Watt FM, Lo Celso C, Silva-Vargas V, 2006, Epidermal stem cells: an update, CURRENT OPINION IN GENETICS & DEVELOPMENT, Vol: 16, Pages: 518-524, ISSN: 0959-437X
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- Citations: 155
Morita K, Lo Celso C, Spencer-Dene B, et al., 2006, HAN11 binds mDia1 and controls GLI1 transcriptional activity, JOURNAL OF DERMATOLOGICAL SCIENCE, Vol: 44, Pages: 11-20, ISSN: 0923-1811
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- Citations: 23
Silva-Vargas V, Lo Celso C, Giangreco A, et al., 2005, β-catenin and hedgehog signal strength can specify number and location of hair follicles in adult epidermis without recruitment of bulge stem cells, DEVELOPMENTAL CELL, Vol: 9, Pages: 121-131, ISSN: 1534-5807
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- Citations: 202
Lo Celso C, Prowse DM, Watt FM, 2004, Transient activation of β-catenin signalling in adult mouse epidermis is sufficient to induce new hair follicles but continuous activation is required to maintain hair follicle tumours, DEVELOPMENT, Vol: 131, Pages: 1787-1799, ISSN: 0950-1991
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- Citations: 252
Medico E, Gentile A, Lo Celso C, et al., 2001, Osteopontin is an autocrine mediator of hepatocyte growth factor-induced invasive growth, CANCER RESEARCH, Vol: 61, Pages: 5861-5868, ISSN: 0008-5472
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- Citations: 64
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