Summary
Clara is a Research Fellow at the IRDB, Department of Metabolism, Digestion and Reproduction.
After completing her Ph.D. in Genetics at the University of Leicester, Clara was a Postdoctoral Fellow at the Institute Curie (Paris), where she studied the replication and organisation of telomeres, and then at the Institute GIGA (Liege), when she investigated the epigenetic alterations of telomeres in cancer cells. Clara then joined the Babraham Institute (Cambridge) to study the three-dimensional organisation of the genome in stem cells and reprogramming.
Clara uses the transiting pluripotency states of embryonic stem cells to understand the molecular mechanisms responsible for genome stability and architecture.
Selected Publications
Journal Articles
Novo CL, Wong E, Hockings C, et al., 2022, Satellite repeat transcripts modulate heterochromatin condensates and safeguard chromosome stability in mouse embryonic stem cells, Nature Communications, Vol:13, ISSN:2041-1723, Pages:1-16
Lopes Novo C, 2021, A tale of two states: pluripotency regulation of telomeres, Frontiers in Cell and Developmental Biology, Vol:9, ISSN:2296-634X
Novo CL, Javierre B-M, Cairns J, et al., 2018, Long-range enhancer interactions are prevalent in mouse embryonic stem cells and are reorganized upon pluripotent state transition, Cell Reports, Vol:22, ISSN:2211-1247, Pages:2615-2627
Novo CL, Rugg-Gunn PJ, 2016, Chromatin organization in pluripotent cells: emerging approaches to study and disrupt function, Briefings in Functional Genomics, Vol:15, ISSN:1473-9550, Pages:305-314
Novo CL, Tang C, Ahmed K, et al., 2016, The pluripotency factor <i>Nanog</i> regulates pericentromeric heterochromatin organization in mouse embryonic stem cells, Genes & Development, Vol:30, ISSN:0890-9369, Pages:1101-1115
Novo CL, Polese C, Matheus N, et al., 2013, A new role for histone deacetylase 5 in the maintenance of long telomeres, The FASEB Journal, Vol:27, ISSN:0892-6638, Pages:3632-3642
Novo C, Arnoult N, Bordes W-Y, et al., 2013, The heterochromatic chromosome caps in great apes impact telomere metabolism, Nucleic Acids Research, Vol:41, ISSN:0305-1048, Pages:4792-4801
Novo CL, Londono-Vallejo JA, 2013, Telomeres and the nucleus, Seminars in Cancer Biology, Vol:23, ISSN:1044-579X, Pages:116-124