Imperial College London
Alternate

ProfessorCeciliaMattevi

Faculty of Engineering, Department of Materials

Professor of Materials Science
 
 
 
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Contact

 

+44 (0)20 7594 0833c.mattevi

 
 
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Location

 

2.11Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Weiss:2020:10.1021/acsnano.0c03697,
author = {Weiss, C and Carriere, M and Fusco, L and Capua, I and Regla-Nava, JA and Pasquali, M and Scott, JA and Vitale, F and Unal, MA and Mattevi, C and Bedognetti, D and Merkoçi, A and Tasciotti, E and Yilmazer, A and Gogotsi, Y and Stellacci, F and Delogu, LG},
doi = {10.1021/acsnano.0c03697},
journal = {ACS Nano},
pages = {6383--6406},
title = {Toward nanotechnology-enabled approaches against the COVID-19 pandemic},
url = {http://dx.doi.org/10.1021/acsnano.0c03697},
volume = {14},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The COVID-19 outbreak has fueled a global demand for effective diagnosis and treatment as well as mitigation of the spread of infection, all through large-scale approaches such as specific alternative antiviral methods and classical disinfection protocols. Based on an abundance of engineered materials identifiable by their useful physicochemical properties through versatile chemical functionalization, nanotechnology offers a number of approaches to cope with this emergency. Here, through a multidisciplinary Perspective encompassing diverse fields such as virology, biology, medicine, engineering, chemistry, materials science, and computational science, we outline how nanotechnology-based strategies can support the fight against COVID-19, as well as infectious diseases in general, including future pandemics. Considering what we know so far about the life cycle of the virus, we envision key steps where nanotechnology could counter the disease. First, nanoparticles (NPs) can offer alternative methods to classical disinfection protocols used in healthcare settings, thanks to their intrinsic antipathogenic properties and/or their ability to inactivate viruses, bacteria, fungi, or yeasts either photothermally or via photocatalysis-induced reactive oxygen species (ROS) generation. Nanotechnology tools to inactivate SARS-CoV-2 in patients could also be explored. In this case, nanomaterials could be used to deliver drugs to the pulmonary system to inhibit interaction between angiotensin-converting enzyme 2 (ACE2) receptors and viral S protein. Moreover, the concept of "nanoimmunity by design" can help us to design materials for immune modulation, either stimulating or suppressing the immune response, which would find applications in the context of vaccine development for SARS-CoV-2 or in counteracting the cytokine storm, respectively. In addition to disease prevention and therapeutic potential, nanotechnology has important roles in diagnostics, with potential to sup
AU  - Weiss,C
AU  - Carriere,M
AU  - Fusco,L
AU  - Capua,I
AU  - Regla-Nava,JA
AU  - Pasquali,M
AU  - Scott,JA
AU  - Vitale,F
AU  - Unal,MA
AU  - Mattevi,C
AU  - Bedognetti,D
AU  - Merkoçi,A
AU  - Tasciotti,E
AU  - Yilmazer,A
AU  - Gogotsi,Y
AU  - Stellacci,F
AU  - Delogu,LG
DO  - 10.1021/acsnano.0c03697
EP  - 6406
PY  - 2020///
SN  - 1936-0851
SP  - 6383
TI  - Toward nanotechnology-enabled approaches against the COVID-19 pandemic
T2  - ACS Nano
UR  - http://dx.doi.org/10.1021/acsnano.0c03697
UR  - https://www.ncbi.nlm.nih.gov/pubmed/32519842
UR  - https://pubs.acs.org/doi/10.1021/acsnano.0c03697
UR  - http://hdl.handle.net/10044/1/79931
VL  - 14
ER  -
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