Dr Charalambos Michaeloudes is an Honorary Research Fellow at the Airway Disease Section of the National Heart and Lung Institute. His research is focused on the cellular and molecular mechanisms leading to the development of airway remodelling in asthma and chronic obstructive pulmonary disease (COPD), with particular focus on airway smooth muscle cell and fibroblast biology. His work aims to identify novel therapeutic targets for these diseases.
- Molecular mechanisms regulating oxidant-antioxidant balance in the airways
- Role of redox signalling in the development of airway remodelling
- Mitochondrial dysfunction and metabolic re-programming in asthma and COPD
- Molecular mechanisms of intracellular and intercellular mitochondrial movement
Dr Michaeloudes has received funding from the British Heart Foundation and European Respiratory Society. He has published articles in leading medical and scientific journals and has given numerous talks at national and international conferences. He serves as manuscript reviewer for medical and scientific journals and as abstract reviewer for the European Respiratory Society International Congress. Dr Michaeloudes teaches on undergraduate and postgraduate programmes and acts as a PhD co-supervisor.
et al., 2020, Role of metabolic reprogramming in pulmonary innate immunity and Its impact on lung diseases, Journal of Innate Immunity, Vol:12, ISSN:1662-811X, Pages:1-16
et al., 2019, Bromodomain and extra-terminal (BET) protein inhibition restores redox balance and inhibits myofibroblast activation, Biomed Research International, Vol:2019, ISSN:2314-6133
et al., 2018, DNA methylation modules in airway smooth muscle are associated with asthma severity, European Respiratory Journal, Vol:51, ISSN:0903-1936
et al., 2019, Mechanisms of Mitochondrial Transfer in Health and Disease, International Conference of the American-Thoracic-Society, AMER THORACIC SOC, ISSN:1073-449X
et al., 2019, Effect of Corticosteroids on Metabolic Gene Expression in Airway Smooth Muscle Cells, International Conference of the American-Thoracic-Society, AMER THORACIC SOC, ISSN:1073-449X