Imperial College London

DrCharalambosMichaeloudes

Faculty of MedicineNational Heart & Lung Institute

Honorary Research Fellow
 
 
 
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Contact

 

c.michaeloudes04

 
 
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Location

 

223Guy Scadding BuildingRoyal Brompton Campus

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Summary

 

Summary

Dr Charalambos Michaeloudes is an Honorary Research Fellow at the Airway Disease Section of the National Heart and Lung Institute. His research is focused on the cellular and molecular mechanisms leading to the development of airway remodelling in asthma and chronic obstructive pulmonary disease (COPD), with particular focus on airway smooth muscle cell and fibroblast biology. His work aims to identify novel therapeutic targets for these diseases.

 Research interests:

  • Molecular mechanisms regulating oxidant-antioxidant balance in the airways
  • Role of redox signalling in the development of airway remodelling
  • Mitochondrial dysfunction and metabolic re-programming in asthma and COPD
  • Molecular mechanisms of intracellular and intercellular mitochondrial movement

Dr Michaeloudes has received funding from the British Heart Foundation and European Respiratory Society.  He has published articles in leading medical and scientific journals and has given numerous talks at national and international conferences. He serves as manuscript reviewer for medical and scientific journals and as abstract reviewer for the European Respiratory Society International Congress. Dr Michaeloudes teaches on undergraduate and postgraduate programmes and acts as a PhD co-supervisor.

Publications

Journals

Michaeloudes C, Bhavsar PK, Mumby S, et al., 2020, Role of metabolic reprogramming in pulmonary innate immunity and Its impact on lung diseases, Journal of Innate Immunity, Vol:12, ISSN:1662-811X, Pages:1-16

Stock CJW, Michaeloudes C, Leoni P, et al., 2019, Bromodomain and extra-terminal (BET) protein inhibition restores redox balance and inhibits myofibroblast activation, Biomed Research International, Vol:2019, ISSN:2314-6133

Perry MM, Lavender P, Scott Kuo C-H, et al., 2018, DNA methylation modules in airway smooth muscle are associated with asthma severity, European Respiratory Journal, Vol:51, ISSN:0903-1936

Conference

Garcia JF, Michaeloudes C, Xu B, et al., 2019, Mechanisms of Mitochondrial Transfer in Health and Disease, International Conference of the American-Thoracic-Society, AMER THORACIC SOC, ISSN:1073-449X

Tsang J, Xu B, Xie J, et al., 2019, Effect of Corticosteroids on Metabolic Gene Expression in Airway Smooth Muscle Cells, International Conference of the American-Thoracic-Society, AMER THORACIC SOC, ISSN:1073-449X

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