Dr Charalambos Michaeloudes is an Honorary Research Fellow at the Airway Disease Section of the National Heart and Lung Institute. His research is focused on the cellular and molecular mechanisms leading to the development of airway remodelling in asthma and chronic obstructive pulmonary disease (COPD), with particular focus on airway smooth muscle cell and fibroblast biology. His work aims to identify novel therapeutic targets for these diseases.
- Molecular mechanisms regulating oxidant-antioxidant balance in the airways
- Role of redox signalling in the development of airway remodelling
- Mitochondrial dysfunction and metabolic re-programming in asthma and COPD
- Molecular mechanisms of intracellular and intercellular mitochondrial movement
Dr Michaeloudes has received funding from the British Heart Foundation and European Respiratory Society. He has published articles in leading medical and scientific journals and has given numerous talks at national and international conferences. He serves as manuscript reviewer for medical and scientific journals and as abstract reviewer for the European Respiratory Society International Congress. Dr Michaeloudes teaches on undergraduate and postgraduate programmes and acts as a PhD co-supervisor.
et al., 2020, Effect of silver nanospheres and nanowires on human airway smooth muscle cells: role of sulfidation, Nanoscale Advances, Vol:2, ISSN:2516-0230, Pages:5635-5647
et al., 2020, Mitochondrial dysfunction in airways and quadriceps muscle of patients with Chronic Obstructive Pulmonary Disease, Respiratory Research, Vol:21, ISSN:1465-9921
et al., 2020, TLR3/TAK1 signalling regulates rhinovirus-induced interleukin-33 in bronchial smooth muscle cells, Erj Open Research, Vol:6
et al., 2020, Role of metabolic reprogramming in pulmonary innate immunity and Its impact on lung diseases, Journal of Innate Immunity, Vol:12, ISSN:1662-811X, Pages:1-16
et al., 2019, REGULATION OF MITOCHONDRIAL TRANSFER BETWEEN AIRWAY SMOOTH MUSCLE CELLS (ASMCS): RELEVANCE TO COPD, Winter Meeting of the British-Thoracic-Society, BMJ PUBLISHING GROUP, Pages:A48-A49, ISSN:0040-6376