Publications
70 results found
Starke RD, Paschalaki K, Millar CM, et al., 2014, Von Willebrand factor (VWF) regulates angiogenesis through angiopoietin-2 (Ang-2)-dependent and independent pathways, ANGIOGENESIS, Vol: 17, Pages: 290-290, ISSN: 0969-6970
Yu Y, Millar CM, 2014, Measurement of factor IX activity in plasma-derived and recombinant concentrates: insights from thrombin generation and activation-based assays, JOURNAL OF THROMBOSIS AND HAEMOSTASIS, Vol: 12, Pages: 62-70, ISSN: 1538-7933
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- Citations: 12
Millar CM, 2014, vCJD and hemophilia, TEXTBOOK OF HEMOPHILIA, 3RD EDITION, Editors: Lee, Berntorp, Hoots, Publisher: BLACKWELL SCIENCE PUBL, Pages: 277-282, ISBN: 978-1-118-39824-1
Mannucci PM, Kempton C, Millar C, et al., 2013, Pharmacokinetics and safety of a novel recombinant human von Willebrand factor manufactured with a plasma-free method: a prospective clinical trial, BLOOD, Vol: 122, Pages: 648-657, ISSN: 0006-4971
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- Citations: 91
Starke RD, Paschalaki KE, Dyer CEF, et al., 2013, Defective angiopoietin-2 release from von Willebrand disease patients' blood outgrowth endothelial cells, JOURNAL OF THROMBOSIS AND HAEMOSTASIS, Vol: 11, Pages: 175-175, ISSN: 1538-7933
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- Citations: 3
Mangles SE, Paschalaki KE, Starke RD, et al., 2013, Increased fibrinolysis on blood outgrowth endothelial cells (BOEC) from chronic thromboembolic pulmonary hypertension (CTEPH) patients, JOURNAL OF THROMBOSIS AND HAEMOSTASIS, Vol: 11, Pages: 920-921, ISSN: 1538-7933
Yu Y, Laffan MA, Millar CM, 2013, Treatment of haemophilia B- comparison study of the <i>in vitro</i> activities of plasma derived and recombinant factor IX, JOURNAL OF THROMBOSIS AND HAEMOSTASIS, Vol: 11, Pages: 538-539, ISSN: 1538-7933
Lentaigne CE, Sodhi V, Usman N, et al., 2013, Haemostatic management of pregnant women with platelet function disorders: utility of PFA-100, JOURNAL OF THROMBOSIS AND HAEMOSTASIS, Vol: 11, Pages: 1152-1152, ISSN: 1538-7933
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- Citations: 1
Millar CM, Lane DA, 2013, Blocking direct inhibitor bleeding, BLOOD, Vol: 121, Pages: 3543-3544, ISSN: 0006-4971
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- Citations: 8
Starke R, Paschalaki K, Dyer C, et al., 2013, DEFECTIVE VON WILLEBRAND FACTOR AND ANGIOPOIETIN-2 RELEASE FROM VON WILLEBRAND DISEASE PATIENTS' BLOOD OUTGROWTH ENDOTHELIAL CELLS, Annual Conference of the British-Cardiovascular-Society (BCS), Publisher: BMJ PUBLISHING GROUP, Pages: A106-A106, ISSN: 1355-6037
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- Citations: 1
Watson HG, Wilde JT, Dolan G, et al., 2013, Update to UKHCDO guidance on vaccination against hepatitis A and B viruses in patients with inherited coagulation factor deficiencies and von Willebrand disease, HAEMOPHILIA, Vol: 19, Pages: E191-E192, ISSN: 1351-8216
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- Citations: 5
Starke RD, Paschalaki KE, Dyer CE, et al., 2013, Cellular and molecular basis of von Willebrand disease: studies on blood outgrowth endothelial cells, Blood, Vol: 121, Pages: 2773-2784
Von Willebrand disease (VWD) is a heterogeneous bleeding disorder caused by decrease or dysfunction of von Willebrand factor (VWF). A wide range of mutations in the VWF gene have been characterized; however, their cellular consequences are still poorly understood. Here we have used a recently developed approach to study the molecular and cellular basis of VWD. We isolated blood outgrowth endothelial cells (BOECs) from peripheral blood of 4 type 1 VWD and 4 type 2 VWD patients and 9 healthy controls. We confirmed the endothelial lineage of BOECs, then measured VWF messenger RNA (mRNA) and protein levels (before and after stimulation) and VWF multimers. Decreased mRNA levels were predictive of plasma VWF levels in type 1 VWD, confirming a defect in VWF synthesis. However, BOECs from this group of patients also showed defects in processing, storage, and/or secretion of VWF. Levels of VWF mRNA and protein were normal in BOECs from 3 type 2 VWD patients, supporting the dysfunctional VWF model. However, 1 type 2M patient showed decreased VWF synthesis and storage, indicating a complex cellular defect. These results demonstrate for the first time that isolation of endothelial cells from VWD patients provides novel insight into cellular mechanisms of the disease
Starke RD, Paschalaki KE, Dyer CEF, et al., 2013, Cellular and molecular basis of von Willebrand disease: studies on blood outgrowth endothelial cells, BLOOD, Vol: 121, Pages: 2773-2784, ISSN: 0006-4971
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- Citations: 69
Nowak AA, Harris DNF, Laffan M, et al., 2012, Evaluation of Primary Haemostasis in Patients Undergoing Cardiac Surgery Using a Novel Automated Microchip Flow-Chamber System (T-TAS), 54th Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), Publisher: AMER SOC HEMATOLOGY, ISSN: 0006-4971
Millar CM, Makris M, 2012, Dealing with the uncertain risk of variant Creutzfeldt-Jakob disease transmission by coagulation replacement products, BRITISH JOURNAL OF HAEMATOLOGY, Vol: 158, Pages: 442-452, ISSN: 0007-1048
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- Citations: 10
McKinnon TAJ, Nowak AA, Cutler J, et al., 2012, Characterisation of von Willebrand factor A1 domain mutants I1416N and I1416T: correlation of clinical phenotype with flow-based platelet adhesion, JOURNAL OF THROMBOSIS AND HAEMOSTASIS, Vol: 10, Pages: 1409-1416, ISSN: 1538-7933
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- Citations: 5
Ranger A, Manning RA, Lyall H, et al., 2012, Pregnancy in type 2B VWD: a case series, HAEMOPHILIA, Vol: 18, Pages: 406-412, ISSN: 1351-8216
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- Citations: 15
McKinnon TAJ, Nowak AA, Hua A, et al., 2011, Flow Analysis of Von Willebrand Factor Collagen Binding Mutants, 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis, Publisher: AMER SOC HEMATOLOGY, Pages: 963-963, ISSN: 0006-4971
Zaman SMA, Hill FGH, Palmer B, et al., 2011, The risk of variant Creutzfeldt-Jakob disease among UK patients with bleeding disorders, known to have received potentially contaminated plasma products, HAEMOPHILIA, Vol: 17, Pages: 931-937, ISSN: 1351-8216
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- Citations: 23
Wilde JT, Mutimer D, Dolan G, et al., 2011, UKHCDO guidelines on the management of HCV in patients with hereditary bleeding disorders 2011, HAEMOPHILIA, Vol: 17, Pages: E877-E883, ISSN: 1351-8216
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- Citations: 9
McKinnon T, Nowak A, Goyder A, et al., 2011, Characterisation of von Willebrand factor A1 domain mutants 1416N and I1416T: application of flow-based platelet adhesion assays, JOURNAL OF THROMBOSIS AND HAEMOSTASIS, Vol: 9, Pages: 668-669, ISSN: 1538-7933
Peden A, McCardle L, Head MW, et al., 2010, Variant CJD infection in the spleen of a neurologically asymptomatic UK adult patient with haemophilia, HAEMOPHILIA, Vol: 16, Pages: 296-304, ISSN: 1351-8216
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- Citations: 176
Millar CM, Connor N, Dolan G, et al., 2010, Risk reduction strategies for variant Creutzfeldt-Jakob disease transmission by UK plasma products and their impact on patients with inherited bleeding disorders, HAEMOPHILIA, Vol: 16, Pages: 305-315, ISSN: 1351-8216
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- Citations: 19
Riddell AF, Gomez K, Millar CM, et al., 2009, Characterization of W1745C and S1783A: 2 novel mutations causing defective collagen binding in the A3 domain of von Willebrand factor, Blood
Hill FGH, Zaman A, Connor N, et al., 2009, Extent of exposure to and risk stratification of UK patients reated with plasma concentrates with contribution from a donor who developed vCJD, Publisher: ELSEVIER SCIENCE INC, Pages: 114-114, ISSN: 1538-7933
Millar CM, Riddell AF, Mellors G, et al., 2009, The spectrum of VWD type 2 phenotypes associated with a1 domain mutations, Publisher: ELSEVIER SCIENCE INC, Pages: 531-532, ISSN: 1538-7933
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- Citations: 1
Ironside JW, Peden A, Head MW, et al., 2009, Detection of PrPSc in the spleen of an adult haemophilic patient in the UK, Publisher: ELSEVIER SCIENCE INC, Pages: 114-114, ISSN: 1538-7933
Riddell A, Gomez K, Millar C, et al., 2008, Characterisation of W1745C and S1783A, Two Novel Collagen . Binding Defects in the A3 Domain of Von Willebrand Factor, 50th Annual Meeting of the American-Society-of-Hematology, Publisher: AMER SOC HEMATOLOGY, Pages: 161-162, ISSN: 0006-4971
Lester W, Guilliatt A, Grundy P, et al., 2008, Is VWF R924Q a benign polymorphism, a marker of a null allele or a factor VIII-binding defect? The debate continues with results from the UKHCDO VWD study, THROMBOSIS AND HAEMOSTASIS, Vol: 100, Pages: 716-718, ISSN: 0340-6245
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- Citations: 7
Millar CM, Riddell AF, Tuddenham EG, 2008, Consideration of platelet function disorders in patients with reduced VWF levels, HAEMOPHILIA, Vol: 14, Pages: 1131-1132, ISSN: 1351-8216
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- Citations: 1
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