Claire Peghaire graduated from the University of Bordeaux (France) with a Doctorate in Pharmacy (PharmD) in 2015.
In 2012, she became a recipient of a fellowship from French Ministry and from GRRC and she went on to undertake a PhD in Cellular Biology, physiology and pathology (2012-2015) at INSERM UNIT 1034 « Biology of Cardiovascular Diseases” in Pessac (France) with Professor Pascale Dufourcq. The project focused on the role of the receptor Frizzled7 in physiological and pathological angiogenesis through the regulation of the canonical Wnt/β-catenin pathway and an interplay with the Notch signalling pathway.
In 2015, she moved to London and became a post-doctoral research associate at the National Heart and Lung Institute (NHLI) at Imperial College London with Professor Anna Randi. Pr Randi's group is focused on the regulation of homeostasis and angiogenesis in vascular biology by the ETS transcription factor ERG.
et al., 2021, Lack of evidence of ACE2 expression and replicative infection by SARSCoV-2 in human endothelial cells, Circulation, Vol:143, ISSN:0009-7322, Pages:865-868
et al., 2020, Dynamic regulation of canonical TGF beta signalling by endothelial transcription factor ERG protects from liver fibrogenesis (vol 31, pg 450, 2017), Nature Communications, Vol:11, ISSN:2041-1723, Pages:1-1
et al., 2019, The transcription factor ERG regulates a low shear stress-induced anti-thrombotic pathway in the microvasculature, Nature Communications, Vol:10, ISSN:2041-1723, Pages:1-17
et al., 2019, The heparin binding domain of von Willebrand factor binds to growth factors and promotes angiogenesis in wound healing, Blood, Vol:133, ISSN:0006-4971, Pages:2559-2569
et al., 2019, The transcription factor ERG regulates super-enhancers associated with an endothelial-specific gene expression program, Circulation Research, Vol:124, ISSN:0009-7330, Pages:1337-1349