Imperial College London
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DrChristinaPrechtl

Faculty of Medicine, School of Public Health

Operations Manager - Clinical Research
 
 
 
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Contact

 

+44 (0)20 7594 5275c.prechtl

 
 
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Location

 

Stadium HouseWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Scholtz:2014:10.1136/gutjnl-2013-305008,
author = {Scholtz, S and Miras, AD and Chhina, N and Prechtl, CG and Sleeth, ML and Daud, NM and Ismail, NA and Durighel, G and Ahmed, AR and Olbers, T and Vincent, RP and Alaghband-Zadeh, J and Ghatei, MA and Waldman, AD and Frost, GS and Bell, JD and le, Roux CW and Goldstone, AP},
doi = {10.1136/gutjnl-2013-305008},
journal = {Gut},
pages = {891--902},
title = {Obese patients after gastric bypass surgery have lower brain-hedonic responses to food than after gastric banding},
url = {http://dx.doi.org/10.1136/gutjnl-2013-305008},
volume = {63},
year = {2014}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Objectives Roux-en-Y gastric bypass (RYGB) has greater efficacy for weight loss in obese patients than gastric banding (BAND) surgery. We hypothesise that this may result from different effects on food hedonics via physiological changes secondary to distinct gut anatomy manipulations.Design We used functional MRI, eating behaviour and hormonal phenotyping to compare body mass index (BMI)-matched unoperated controls and patients after RYGB and BAND surgery for obesity.Results Obese patients after RYGB had lower brain-hedonic responses to food than patients after BAND surgery. RYGB patients had lower activation than BAND patients in brain reward systems, particularly to high-calorie foods, including the orbitofrontal cortex, amygdala, caudate nucleus, nucleus accumbens and hippocampus. This was associated with lower palatability and appeal of high-calorie foods and healthier eating behaviour, including less fat intake, in RYGB compared with BAND patients and/or BMI-matched unoperated controls. These differences were not explicable by differences in hunger or psychological traits between the surgical groups, but anorexigenic plasma gut hormones (GLP-1 and PYY), plasma bile acids and symptoms of dumping syndrome were increased in RYGB patients.Conclusions The identification of these differences in food hedonic responses as a result of altered gut anatomy/physiology provides a novel explanation for the more favourable long-term weight loss seen after RYGB than after BAND surgery, highlighting the importance of the gut–brain axis in the control of reward-based eating behaviour.
AU  - Scholtz,S
AU  - Miras,AD
AU  - Chhina,N
AU  - Prechtl,CG
AU  - Sleeth,ML
AU  - Daud,NM
AU  - Ismail,NA
AU  - Durighel,G
AU  - Ahmed,AR
AU  - Olbers,T
AU  - Vincent,RP
AU  - Alaghband-Zadeh,J
AU  - Ghatei,MA
AU  - Waldman,AD
AU  - Frost,GS
AU  - Bell,JD
AU  - le,Roux CW
AU  - Goldstone,AP
DO  - 10.1136/gutjnl-2013-305008
EP  - 902
PY  - 2014///
SN  - 0017-5749
SP  - 891
TI  - Obese patients after gastric bypass surgery have lower brain-hedonic responses to food than after gastric banding
T2  - Gut
UR  - http://dx.doi.org/10.1136/gutjnl-2013-305008
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=000335360000008&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://gut.bmj.com/content/63/6/891
VL  - 63
ER  -
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