Publications
590 results found
McAdoo S, Bhangal G, Smith J, et al., 2014, Spleen Tyrosine Kinase (SYK) Expression in Antibody-Mediated Renal Allograft Rejection, World Transplant Congress, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 513-514, ISSN: 0041-1337
Smith J, Syed A, Bhangal G, et al., 2014, Treatment With a Spleen Tyrosine Kinase Inhibitor Reduced Inflammation and Protected Kidney Function in Experimental Renal Allograft Rejection, World Transplant Congress, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 27-27, ISSN: 0041-1337
Tanna A, Guarino L, Tam FWK, et al., 2014, Long-term outcome of anti-neutrophil cytoplasm antibody-associated glomerulonephritis: evaluation of the international histological classification and other prognostic factors, Nephrology Dialysis Transplantation, Vol: 30, Pages: 1185-1192, ISSN: 1460-2385
Background Anti-neutrophil cytoplasm antibody (ANCA) associated vasculitis with renal involvement requires treatment with potentially toxic drugs to reduce morbidity and mortality, and there is a major challenge to determine clinical and histological features predictive of renal prognosis. The aim of our study was to evaluate the use of the 2010 international histological classification for ANCA-associated glomerulonephritis (AAGN) as a predictor of renal outcome when used in conjunction with other prognostic factors.Methods One hundred and four patients with AAGN treated at our centre were included: 23 were classified as focal, 26 as crescentic, 48 as mixed and 7 as sclerotic. Renal outcomes were based on estimated glomerular filtration rate (eGFR) at 1 and 5 years, and on renal survival.Results By univariate analysis, patients in the focal class had the best renal outcome, those in the sclerotic class the worst outcome, and those in the mixed and crescentic classes had intermediate renal survival. There was no significant difference in outcome between the mixed and crescentic classes. In multivariate models, histological class did not improve model fit or associate with renal outcome after adjusting for established prognostic factors. Lower percentage of normal glomeruli, greater degree of tubular atrophy (TA), MPO-ANCA positivity, increasing age and lower starting eGFR, all correlated with poorer renal outcomes.Conclusions We conclude that, in our cohort of patients, the international histological classification is predictive of renal outcome in AAGN, but did not appear to be additionally informative over other established prognostic factors in multivariate analysis. However, it may be of value to combine the current histological classification with other established parameters, such as TA and percentage normal glomeruli.
Tan LT, Davagnanam I, Isa H, et al., 2014, Clinical and Imaging Features Predictive of Orbital Granulomatosis with Polyangiitis and the Risk of Systemic Involvement, OPHTHALMOLOGY, Vol: 121, Pages: 1304-1309, ISSN: 0161-6420
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- Citations: 26
Rahmattulla C, van Wijngaarden RADL, Berden AE, et al., 2014, RENAL FUNCTION IN ANCA-ASSOCIATED VASCULITIS IS ASSOCIATED WITH ENT INVOLVEMENT, 15th Annual European Congress of Rheumatology (EULAR), Publisher: BMJ PUBLISHING GROUP, Pages: 552-552, ISSN: 0003-4967
McAdoo S, Bhangal G, Smith J, et al., 2014, Spleen Tyrosine Kinase (SYK) Expression in Antibody-Mediated Renal Allograft Rejection, World Transplant Congress, Publisher: WILEY-BLACKWELL, Pages: 513-514, ISSN: 1600-6135
Smith J, Syed A, Bhangal G, et al., 2014, Treatment With a Spleen Tyrosine Kinase Inhibitor Reduced Inflammation and Protected Kidney Function in Experimental Renal Allograft Rejection., World Transplant Congress, Publisher: WILEY-BLACKWELL, Pages: 27-27, ISSN: 1600-6135
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- Citations: 1
Woollard KJ, Pusey CD, 2014, The heterogeneous mononuclear phagocyte system of the kidney, KIDNEY INTERNATIONAL, Vol: 85, Pages: 1011-1014, ISSN: 0085-2538
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- Citations: 4
Tarzi RM, Pusey CD, 2014, Current and future prospects in the management of granulomatosis with polyangiitis (Wegener's granulomatosis), THERAPEUTICS AND CLINICAL RISK MANAGEMENT, Vol: 10, Pages: 279-293
McAdoo SP, Pusey CD, 2014, Should Rituximab Be Used to Prevent Relapse in Patients with ANCA-Associated Vasculitis?, CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, Vol: 9, Pages: 641-644, ISSN: 1555-9041
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- Citations: 4
McAdoo SP, Tanna A, McDaid J, et al., 2014, SYK inhibition in experimental autoimmune vasculitis and its glomerular expression in ANCA-associated vasculitis, LANCET, Vol: 383, Pages: 72-72, ISSN: 0140-6736
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- Citations: 3
Kim MJ, Turner CM, Hewitt R, et al., 2014, Exaggerated renal fibrosis in P2X4 receptor-deficient mice following unilateral ureteric obstruction, Nephrology Dialysis Transplantation, Vol: 29, Pages: 1350-1361, ISSN: 1460-2385
Background. The ATP-sensitive P2X7 receptor (P2X7R) hasbeen shown to contribute to renal injury in nephrotoxic nephritis,a rodent model of acute glomerulonephritis, and in unilateral uretericobstruction (UUO), a rodent model of chronic interstitialinflammation and fibrosis. Renal tubular cells, endothelial cellsand macrophages also express the closely related P2X4 receptor(P2X4R), which is chromosomally co-located with P2X7R andhas 40% homology; it is also pro-inflammatory and has beenshown to interact with P2X7R to modulate its pro-apoptotic andpro-inflammatory effects. Therefore, we chose to explore the functionof P2X4R in the UUO model of renal injury using knockoutmice. We hypothesized that UUO-induced tubulointerstitialdamage and fibrosis would also be attenuated in P2X4R−/− mice.Method. P2X4R−/− and wild-type (WT) mice were subjectedto either UUO or sham operation. Kidney samples taken onDays 7 and 14 were evaluated for renal inflammation and fi-brosis, and expression of pro-fibrotic factors.Results. To our surprise, the obstructed kidney in P2X4R−/−mice showed more severe renal injury, more collagen deposition( picrosirius red staining, increase of 53%; P < 0.05) andmore type I collagen staining (increase of 107%; P < 0.01), aswell as increased mRNA for TGF-β (increase of 102%, P <0.0005) and CTGF (increase of 157%; P < 0.05) by Day 14,compared with the UUO WT mice.Conclusion. These findings showed that lack of P2X4Rexpression leads to increased renal fibrosis, and increasedexpression of TGF-β and CTGF in the UUO model.
Tanna A, Tam FWK, Pusey CD, 2013, B-cell-targeted therapy in adult glomerulonephritis, EXPERT OPINION ON BIOLOGICAL THERAPY, Vol: 13, Pages: 1691-1706, ISSN: 1471-2598
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- Citations: 8
Reynolds J, Preston GA, Pressler BM, et al., 2013, Autoimmunity to the alpha 3 chain of type IV collagen is triggered by 'autoantigen complementarity', Annual Congress of the British-Society-for-Immunology, Publisher: WILEY-BLACKWELL, Pages: 48-49, ISSN: 0019-2805
Tarzi R, Pusey C, 2013, VASCULITIS SYNDROMES RAVE about rituximab in ANCA vasculitis?, NATURE REVIEWS NEUROLOGY, Vol: 9, Pages: 628-629, ISSN: 1759-4758
Tarzi R, Pusey C, 2013, VASCULITIS SYNDROMES RAVE about rituximab in ANCA vasculitis?, NATURE REVIEWS NEPHROLOGY, Vol: 9, Pages: 628-629, ISSN: 1759-5061
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- Citations: 1
D'Souza Z, McAdoo SP, Smith J, et al., 2013, Experimental crescentic glomerulonephritis: a new bicongenic rat model, DISEASE MODELS & MECHANISMS, Vol: 6, Pages: 1477-1486, ISSN: 1754-8403
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- Citations: 10
Manzouri B, Shankar V, Sim D, et al., 2013, Bilateral Subconjunctival Masses as a Rare Presentation of Churg-Strauss Syndrome, OCULAR IMMUNOLOGY AND INFLAMMATION, Vol: 21, Pages: 333-336, ISSN: 0927-3948
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- Citations: 5
Walsh M, Casian A, Flossmann O, et al., 2013, Long-term follow-up of patients with severe ANCA-associated vasculitis comparing plasma exchange to intravenous methylprednisolone treatment is unclear, KIDNEY INTERNATIONAL, Vol: 84, Pages: 397-402, ISSN: 0085-2538
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- Citations: 181
Tonneijck L, Tanna A, Pusey CD, 2013, Antineutrophil cytoplasm antibody-positive pulmonary-renal syndrome in a patient with diffuse cutaneous systemic sclerosis., BMJ Case Rep, Vol: 2013
A 72-year-old male patient with known diffuse cutaneous systemic sclerosis (SSc) presented with severe haemoptysis and blood and protein in the urine. In light of his known interstitial lung disease, he had been repeatedly treated for recurrent community-acquired pneumonia. Immunological testing demonstrated a strongly positive perinuclear antineutrophil cytoplasm antibody with a high titre antimyeloperoxidase antibody. The patient was diagnosed with pulmonary-renal syndrome as a consequence of antineutrophil cytoplasm antibody-associated vasculitis. He started immediate plasmapheresis in combination with methylprednisolone, followed by cyclophosphamide and rituximab, with good clinical outcome.
Croft A, Smith SW, Carr S, et al., 2013, SUCCESSFUL OUTCOMES OF PREGNANCY IN PATIENTS WITH ANCA VASCULITIS, ANNALS OF THE RHEUMATIC DISEASES, Vol: 71, Pages: 222-223, ISSN: 0003-4967
Power A, Duncan N, Pusey C, et al., 2013, PATIENT-LEVEL FACTORS ASSOCIATED WITH CEREBROVASCULAR EVENTS IN MAINTENANCE HEMODIALYSIS, 50th European-Renal-Association - European-Dialysis-and-Transplant-Association Congress, Publisher: OXFORD UNIV PRESS, Pages: 85-85, ISSN: 0931-0509
West SC, Arulkumaran N, Ind PW, et al., 2013, Pulmonary-renal syndrome: a life threatening but treatable condition, POSTGRADUATE MEDICAL JOURNAL, Vol: 89, Pages: 274-283, ISSN: 0032-5473
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- Citations: 28
Moschidou D, Sharp P, Behmoaras J, et al., 2013, Potential of human fetal chorionic stem cell therapy for Alport Syndrome, Conference of the British-Society-for-Gene-and-Cell-Therapy (BSGCT), Publisher: MARY ANN LIEBERT INC, Pages: A12-A12, ISSN: 1043-0342
Luong L, Fragiadaki M, Smith J, et al., 2013, Cezanne Regulates Inflammatory Responses to Hypoxia in Endothelial Cells by Targeting TRAF6 for Deubiquitination., Circ Res
Rationale: Hypoxia followed by reoxygenation promotes inflammation by activating NF-κB transcription factors in endothelial cells (EC). This process involves modification of the signalling intermediary TRAF6 with polyubiquitin chains. Thus cellular mechanisms that suppress TRAF6 ubiquitination are potential therapeutic targets to reduce inflammation in hypoxic tissues. Objective: In this study, we tested the hypothesis that endothelial activation in response to hypoxia-reoxygenation can be influenced by Cezanne, a deubiquitinating enzyme that cleaves ubiquitin from specific modified proteins. Methods and Results: Studies of cultured endothelial cells (EC) demonstrated that hypoxia (1% oxygen) induced Cezanne via p38 MAP kinase-dependent transcriptional and post-transcriptional mechanisms. Hypoxia-reoxygenation had minimal effects on pro-inflammatory signalling in unmanipulated EC but significantly enhanced Lys-63 polyubiquitination of TRAF6, activation of NF-κB and expression of inflammatory genes following silencing of Cezanne. Thus although hypoxia primed cells for inflammatory activation it simultaneously induced Cezanne which impeded signalling to NF-κB by suppressing TRAF6 ubiquitination. Similarly, ischemia induced Cezanne in the murine kidney in vascular EC, glomerular EC, podocytes and epithelial cells, and genetic deletion of Cezanne enhanced renal inflammation and injury in murine kidneys exposed to ischemia followed by reperfusion. Conclusions: We conclude that inflammatory responses to ischemia are controlled by a balance between ubiquitination and deubiquitination and that Cezanne is a key regulator of this process. Our observations have important implications for therapeutic targeting of inflammation and injury during ischemia-reperfusion.
Croft AP, Smith S, Carr S, et al., 2013, SUCCESSFUL PREGNANCY OUTCOMES IN PATIENTS WITH ANCA VASCULITIS, Annual Meeting of the British-Society-for-Rheumatology and British-Health-Professionals-in-Rheumatology, Publisher: OXFORD UNIV PRESS, Pages: 171-172, ISSN: 1462-0324
McAdoo SP, Pusey CD, 2013, Novel forms of clinical vasculitis: Anti-GBM vasculitis (Goodpasture's disease), PRESSE MEDICALE, Vol: 42, Pages: 625-628, ISSN: 0755-4982
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- Citations: 2
Mcdaid JP, Tanna A, Bhangal G, et al., 2013, The role of quantitative trait loci (QTL) in the pathogenesis of experimental autoimmune vasculitis (EAV), Publisher: MASSON EDITEUR, Pages: 688-688, ISSN: 0755-4982
Pepper RJ, Chanouzas D, Tarzi R, et al., 2013, European Vasculitis Study (EUVAS) investigators: Intravenous cyclophosphamide and plasmapheresis in dialysis-dependent ANCA-associated vasculitis (vol 8, pg 219, 2013), CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, Vol: 8, Pages: 701-701, ISSN: 1555-9041
Goceroglu A, Van Wijngaarden RAFDL, Berden AE, et al., 2013, Predicting renal relapse with the histopathologic classification of ANCA-associated glomerulonephritis, PRESSE MEDICALE, Vol: 42, Pages: 750-751, ISSN: 0755-4982
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