Imperial College London

MissChloePyle

Faculty of Natural SciencesDepartment of Life Sciences

 
 
 
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Contact

 

c.pyle

 
 
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Location

 

Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Summary

Chloe gained her BSc (Hons) in Biomedical Science at Kings College London, and after graduating worked for two years as a Research Scientist for a contract research company, using models of inflammatory disease to progress novel compounds from hit identification through to lead optimization. In 2015 she came to Imperial College and worked for four years as Research Assistant to Dr James Harker.

During her time in the Harker lab she focused on two main areas of research:

  • The role of IL-6 in regulating the immune response to Respiratory Syncytial Virus (RSV)
  • The regulation of antibody production in early life, particularly in RSV infection

In 2018 she joined Dr Robert Snelgrove's lab, and currently works on investigating the opposing roles of  LTA4H - an enzyme with both pro-inflammatory (LTB4 generation) and anti-inflammatory (PGP degradation) activity - in dictating neutrophilic inflammation.

Publications

Journals

Pyle C, Patel D, Peiro T, et al., 2022, MMP-12 supports pulmonary B cell follicle formation and local antibody responses during asthma, American Journal of Respiratory and Critical Care Medicine, Vol:206, ISSN:1073-449X, Pages:1424-1428

Pyle CJ, Labeur-Iurman L, Groves HT, et al., 2021, Enhanced IL-2 in early life limits the development of TFH and protective antiviral immunity, Journal of Experimental Medicine, Vol:218, ISSN:0022-1007

Turnbull A, Pyle C, Patel D, et al., 2020, Abnormal pro-gly-pro pathway and airway neutrophilia in pediatric cystic fibrosis, Journal of Cystic Fibrosis, Vol:19, ISSN:1569-1993, Pages:40-48

Conference

Pyle CJ, Patel ND, Wang Z, et al., 2023, A Rhinovirus-A16 VP0 Vaccine Induces Homotypic Humoral and Cellular Immunity, and Following Heterotypic Rhinovirus-A01 Infection, Accelerates Virus Clearance and Induces Cross-strain IFN-γ T Cell and Neutralising Antibody Responses, International Conference of the American-Thoracic-Society (ATS), AMER THORACIC SOC, ISSN:1073-449X

Bruno N, Singanayagam A, Farne HA, et al., 2022, G-CSF drives pathophysiology of RV-induced allergic asthma exacerbations by potentiating neutrophilic inflammation and ILC2 function, EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN:0903-1936

More Publications