Summary
Chloe gained her BSc (Hons) in Biomedical Science at Kings College London, and after graduating worked for two years as a Research Scientist for a contract research company, using models of inflammatory disease to progress novel compounds from hit identification through to lead optimization. In 2015 she came to Imperial College and worked for four years as Research Assistant to Dr James Harker.
During her time in the Harker lab she focused on two main areas of research:
- The role of IL-6 in regulating the immune response to Respiratory Syncytial Virus (RSV)
- The regulation of antibody production in early life, particularly in RSV infection
In 2018 she joined Dr Robert Snelgrove's lab, and currently works on investigating the opposing roles of LTA4H - an enzyme with both pro-inflammatory (LTB4 generation) and anti-inflammatory (PGP degradation) activity - in dictating neutrophilic inflammation.
Publications
Journals
Pyle CJ, Labeur-Iurman L, Groves HT, et al., 2021, Enhanced IL-2 in early life limits the development of TFH and protective antiviral immunity, Journal of Experimental Medicine, Vol:218, ISSN:0022-1007
Turnbull A, Pyle C, Patel D, et al., 2020, Abnormal pro-gly-pro pathway and airway neutrophilia in pediatric cystic fibrosis, Journal of Cystic Fibrosis, Vol:19, ISSN:1569-1993, Pages:40-48
Patel DF, Peiro T, Bruno N, et al., 2019, Neutrophils restrain allergic airway inflammation by limiting ILC2 function and monocyte-dendritic cell antigen presentation, Science Immunology, Vol:4, ISSN:2470-9468, Pages:1-18
Uwadiae F, Pyle C, Walker S, et al., 2019, Targeting the ICOS/ICOS-L pathway in a mouse model of established allergic asthma disrupts T follicular helper cell responses and ameliorates disease, Allergy, Vol:74, ISSN:0105-4538, Pages:650-662