Imperial College London
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MissChloePyle

Faculty of Natural Sciences, Department of Life Sciences

 
 
 
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Contact

 

c.pyle

 
 
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Location

 

Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Pyle:2021:10.1084/jem.20201555,
author = {Pyle, CJ and Labeur-Iurman, L and Groves, HT and Puttur, F and Lloyd, CM and Tregoning, JS and Harker, JA},
doi = {10.1084/jem.20201555},
journal = {Journal of Experimental Medicine},
title = {Enhanced IL-2 in early life limits the development of TFH and protective antiviral immunity},
url = {http://dx.doi.org/10.1084/jem.20201555},
volume = {218},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - T follicular helper cell (TFH)-dependent antibody responses are critical for long-term immunity. Antibody responses are diminished in early life, limiting long-term protective immunity and allowing prolonged or recurrent infection, which may be important for viral lung infections that are highly prevalent in infancy. In a murine model using respiratory syncytial virus (RSV), we show that TFH and the high-affinity antibody production they promote are vital for preventing disease on RSV reinfection. Following a secondary RSV infection, TFH-deficient mice had significantly exacerbated disease characterized by delayed viral clearance, increased weight loss, and immunopathology. TFH generation in early life was compromised by heightened IL-2 and STAT5 signaling in differentiating naive T cells. Neutralization of IL-2 during early-life RSV infection resulted in a TFH-dependent increase in antibody-mediated immunity and was sufficient to limit disease severity upon reinfection. These data demonstrate the importance of TFH in protection against recurrent RSV infection and highlight a mechanism by which this is suppressed in early life.
AU  - Pyle,CJ
AU  - Labeur-Iurman,L
AU  - Groves,HT
AU  - Puttur,F
AU  - Lloyd,CM
AU  - Tregoning,JS
AU  - Harker,JA
DO  - 10.1084/jem.20201555
PY  - 2021///
SN  - 0022-1007
TI  - Enhanced IL-2 in early life limits the development of TFH and protective antiviral immunity
T2  - Journal of Experimental Medicine
UR  - http://dx.doi.org/10.1084/jem.20201555
UR  - https://www.ncbi.nlm.nih.gov/pubmed/34665220
UR  - http://hdl.handle.net/10044/1/92500
VL  - 218
ER  -
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