Imperial College London

Dr Carola I. Radulescu

Faculty of MedicineDepartment of Brain Sciences

Research Associate
 
 
 
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Contact

 

c.radulescu

 
 
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Location

 

Burlington DanesHammersmith Campus

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Summary

 

Summary

I joined the UK DRI at Imperial in October 2018 as a postdoctoral research associate in the Barnes lab and have been conducting single cell in vitro electrophysiology experiments in combination with immunofluorescence labeling to understand the causes and consequences of synaptic mechanisms destabilisation during aging. I am currently running longitudinal 2-Photon in vivo calcium imaging to investigate the spatiotemporal propagation of neuronal
activity during neurodegeneration in the early stages of Alzheimer’s disease.

I undertook my PhD at the University of Sheffield (UK) and the Agency for Science, Technology and Research (A*STAR, Singapore) between 2013 and 2018 after being awarded the ARAP PhD scholarship. The first part of my PhD, in Sheffield, involved concurrent in vitro multi-channel electrophysiology, optogenetics and pharmacological manipulations to investigate corticostriatal communication in the healthy brain. During the second half of my PhD, based at the Translational Laboratory in Genetic Medicine (TLGM), in Singapore, my research took on a translational focus where I investigated the impact of environmental and microbiota manipulations on white matter plasticity and behavioural characteristics in Huntington’s disease models, using a range of techniques, including transmission electron microscopy, histology, and behavioural experiments. Prior to my PhD I undertook an MSc in Cognitive and Computational Neuroscience MSc at the University of Sheffield, during which a key component of my research consisted of the development and application of Matlab based tools to optimise behavioural paradigms and analysis of joystick experiments in rats.

Selected Publications

Journal Articles

Utami KH, Skotte NH, Colaço AR, et al., 2020, Integrative analysis identifies key molecular signatures underlying neurodevelopmental deficits in fragile X syndrome, Biological Psychiatry, ISSN:0006-3223

Knopfel T, Sweeney Y, Radulescu CI, et al., 2019, Audio-visual experience strengthens multisensory assemblies in adult mouse visual cortex, Nature Communications, Vol:10, ISSN:2041-1723

Radulescu CI, Garcia-Miralles M, Sidik H, et al., 2019, Manipulation of microbiota reveals altered callosal myelination and white matter plasticity in a model of Huntington disease, Neurobiology of Disease, Vol:127, ISSN:0969-9961, Pages:65-75

Xu X, Tay Y, Sim B, et al., 2017, Reversal of phenotypic abnormalities by CRISPR/Cas9-mediated gene correction in Huntington disease patient-derived induced pluripotent stem cells, Stem Cell Reports, Vol:8, ISSN:2213-6711, Pages:619-633

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