Imperial College London

Dr Carola I. Radulescu

Faculty of MedicineDepartment of Brain Sciences

Research Associate
 
 
 
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Contact

 

c.radulescu

 
 
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Location

 

Burlington DanesHammersmith Campus

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Summary

 

Summary

I joined the UK DRI at Imperial in October 2018 as a postdoctoral research associate in the Barnes lab and have been conducting single cell in vitro electrophysiology experiments in combination with immunofluorescence labeling to understand the causes and consequences of synaptic mechanisms destabilisation during aging. I am currently running longitudinal 2-Photon in vivo calcium imaging to investigate the spatiotemporal propagation of neuronal
activity during neurodegeneration in the early stages of Alzheimer’s disease.

I undertook my PhD at the University of Sheffield (UK) and the Agency for Science, Technology and Research (A*STAR, Singapore) between 2013 and 2018 after being awarded the ARAP PhD scholarship. The first part of my PhD, in Sheffield, involved concurrent in vitro multi-channel electrophysiology, optogenetics and pharmacological manipulations to investigate corticostriatal communication in the healthy brain. During the second half of my PhD, based at the Translational Laboratory in Genetic Medicine (TLGM), in Singapore, my research took on a translational focus where I investigated the impact of environmental and microbiota manipulations on white matter plasticity and behavioural characteristics in Huntington’s disease models, using a range of techniques, including transmission electron microscopy, histology, and behavioural experiments. Prior to my PhD I undertook an MSc in Cognitive and Computational Neuroscience MSc at the University of Sheffield, during which a key component of my research consisted of the development and application of Matlab based tools to optimise behavioural paradigms and analysis of joystick experiments in rats.

Publications

Journals

Radulescu CI, Garcia-Miralles M, Sidik H, et al., 2019, Manipulation of microbiota reveals altered callosal myelination and white matter plasticity in a model of Huntington disease, Neurobiology of Disease, Vol:127, ISSN:0969-9961, Pages:65-75

Garcia-Miralles M, Yusof NABM, Tan JY, et al., 2019, Laquinimod Treatment Improves Myelination Deficits at the Transcriptional and Ultrastructural Levels in the YAC128 Mouse Model of Huntington Disease, Molecular Neurobiology, Vol:56, ISSN:0893-7648, Pages:4464-4478

Conference

Utami K, Skotte NH, Colaco AR-F, et al., 2019, Neurodevelopmental deficits in human isogenic fragile x syndrome neurons, Joint Meeting of the International-Society-for-Neurochemistry and American-Society-for-Neurochemistry (ISN-ASN), WILEY, Pages:103-103, ISSN:0022-3042

Ziaei A, Garcia-Miralles M, Radulescu C, et al., 2019, Recapitulation of familial multiple sclerosis mutation leads to compromised myelin and susceptibility to demyelination insult, Joint Meeting of the International-Society-for-Neurochemistry and American-Society-for-Neurochemistry (ISN-ASN), WILEY, Pages:103-103, ISSN:0022-3042

Ziaei A, Garcia-Miralles M, Radulescu C, et al., 2019, Recapitulation of familial multiple sclerosis mutation leads to compromised myelin and susceptibility to demyelination insult, Joint Meeting of the International-Society-for-Neurochemistry and American-Society-for-Neurochemistry (ISN-ASN), WILEY, Pages:68-69, ISSN:0022-3042

More Publications