I joined UK DRI at Imperial in October 2018 as a postdoctoral research associate in the Barnes Lab. My main project is currently focused on understanding the causes and consequences of neuronal network and synaptic mechanisms destabilisation during ageing. To investigate this I am combining a number of techniques, including longitudinal 2-Photon in vivo imaging, single cell in vitro electrophysiology, immunofluorescence labelling, behavioural testing and pharmacological interventions. In June 2019, I was awarded one of the UK DRI Pilot Study Awards, in collaboration with Amy Smith (Imperial DRI), for a project titled: Discovery of the integrated optogenetic-transcriptomic signatures of destabilised neuronal activity early in progression of an Alzheimer’s disease model.
In 2012, I obtained a collaborative PhD scholarship award and undertook my PhD at the University of Sheffield (UK) and the Agency for Science, Technology and Research (A*STAR, Singapore) between 2013 and 2018. During the first part of my PhD, in Sheffield, I investigated corticostriatal communication in the healthy brain using concurrent in vitro multi-channel electrophysiology, optogenetics and pharmacological manipulations. The second half of my PhD, based at the Translational Laboratory in Genetic Medicine (TLGM), in Singapore, took on a translational focus. Specifically, my research was focused on the impact of environmental and microbiota manipulations on white matter plasticity in Huntington disease models. Here, I used a range of different techniques, including transmission electron microscopy, histology, and behavioural testing. Prior to my PhD I undertook an MSc in Cognitive and Computational Neuroscience at the University of Sheffield, during which a key component of my research consisted of the development and application of Matlab based tools to optimise behavioural paradigms and analysis of behavioural experiments.
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et al., 2020, pS421 huntingtin modulates mitochondrial phenotypes and confers neuroprotection in an HD hiPSC model, Cell Death & Disease, Vol:11
et al., 2019, Audio-visual experience strengthens multisensory assemblies in adult mouse visual cortex, Nature Communications, Vol:10, ISSN:2041-1723
et al., 2019, Manipulation of microbiota reveals altered callosal myelination and white matter plasticity in a model of Huntington disease, Neurobiology of Disease, Vol:127, ISSN:0969-9961, Pages:65-75
et al., 2017, Reversal of phenotypic abnormalities by CRISPR/Cas9-mediated gene correction in Huntington disease patient-derived induced pluripotent stem cells, Stem Cell Reports, Vol:8, ISSN:2213-6711, Pages:619-633