ProfessorCaetanoReis e Sousa

Reis e Sousa C, 2007, Coupling of innate and adaptive immunity via C-type lectin signalling through Syk kinase, Annual Congress of the British-Society-of-Immunology, Publisher: BLACKWELL PUBLISHING, Pages: 22-22, ISSN: 0019-2805

• Author Web Link
• Cite

Pichlmair A, Diebold SS, Gschmeissner S, Takeuchi Y, Ikeda Y, Collins MK, Sousa CREet al., 2007, Tubulovesicular structures within vesicular stomatitis virus G protein-pseudotyped lentiviral vector preparations carry DNA and stimulate antiviral responses via toll-like receptor 9, JOURNAL OF VIROLOGY, Vol: 81, Pages: 539-547, ISSN: 0022-538X

• Author Web Link
• Cite
• Citations: 74

Diebold SS, Massacrier C, Akira S, Paturel C, Morel Y, Sousa CREet al., 2006, Nucleic acid agonists for toll-like receptor 7 are defined by the presence of uridine ribonucleotides, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 36, Pages: 3256-3267, ISSN: 0014-2980

• Author Web Link
• Cite
• Citations: 210

Robinson MJ, Sancho D, Slack EC, LeibundGut-Landmann S, Sousa CREet al., 2006, Myeloid C-type lectins in innate immunity, NATURE IMMUNOLOGY, Vol: 7, Pages: 1258-1265, ISSN: 1529-2908

• Author Web Link
• Cite
• Citations: 392

Diebold SS, Massacrier C, Akira S, Paturel C, Morel Y, Reis e Sousa Cet al., 2006, Nucleic acid agonists for Toll-like receptor 7 are defined by the presence of uridine ribonucleotides., Eur J Immunol, Vol: 36, Pages: 3256-3267, ISSN: 0014-2980

Toll-like receptor 7 (TLR7) mediates innate responses by responding to viral RNA in endocytic compartments. However, the molecular pattern recognised by TLR7 and whether it differs between RNA of viral and self origin remains unclear. Here, we identify nucleic acids that act as TLR7 agonists for mouse and human cells. We show that uridine and ribose, the two defining features of RNA, are both necessary and sufficient for TLR7 stimulation, and that short single-stranded RNA (ssRNA) act as TLR7 agonists in a sequence-independent manner as long as they contain several uridines in close proximity. Consistent with the notion that TLR7 lacks specificity for sequence motifs, we show that it is triggered equally efficiently by viral or self RNA delivered to endosomes. Our results support the notion that TLR7 recognises uracil repeats in RNA and that it discriminates between viral and self ligands on the basis of endosomal accessibility rather than sequence.

• Abstract
• Author Web Link
• Cite

Pichlmair A, Schulz O, Tan CP, Naslund TI, Liljestrom P, Weber F, Sousa CREet al., 2006, RIG-I-mediated antiviral responses to single-stranded RNA bearing 5′-phosphates, SCIENCE, Vol: 314, Pages: 997-1001, ISSN: 0036-8075

• Author Web Link
• Cite
• Citations: 1721

Reis e Sousa C, 2006, Essay - Dendritic cells in a mature age, NATURE REVIEWS IMMUNOLOGY, Vol: 6, Pages: 476-483, ISSN: 1474-1733

• Author Web Link
• Cite
• Citations: 861

Kato H, Takeuchi O, Sato S, Yoneyama M, Yamamoto M, Matsui K, Uematsu S, Jung A, Kawai T, Ishii KJ, Yamaguchi O, Otsu K, Tsujimura T, Koh CS, Sousa CRE, Matsuura Y, Fujita T, Akira Set al., 2006, Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses, NATURE, Vol: 441, Pages: 101-105, ISSN: 0028-0836

• Author Web Link
• Cite
• Citations: 2847

Rogers NC, Slack EC, Edwards AD, Nolte MA, Schulz O, Schweighoffer E, Williams DL, Gordon S, Tybulewicz VL, Brown GD, Sousa CREet al., 2005, Syk-dependent cytokine induction by dectin-1 reveals a novel pattern recognition pathway for C type lectins (vol 22, pg , 2005), IMMUNITY, Vol: 22, Pages: 773-774, ISSN: 1074-7613

• Author Web Link
• Cite
• Citations: 2

Rogers NC, Slack EC, Edwards AD, Nolte MA, Schulz O, Schweighoffer E, Williams DL, Gordon S, Tybulewicz VL, Brown GD, Sousa CREet al., 2005, Syk-dependent cytokine induction by Dectin-1 reveals a novel pattern recognition pathway for C type lectins, IMMUNITY, Vol: 22, Pages: 507-517, ISSN: 1074-7613

• Author Web Link
• Cite
• Citations: 707

Schulz O, Diebold SS, Chen M, Näslund TI, Nolte MA, Alexopoulou L, Azuma YT, Flavell RA, Liljeström P, Sousa CREet al., 2005, Toll-like receptor 3 promotes cross-priming to virus-infected cells, NATURE, Vol: 433, Pages: 887-892, ISSN: 0028-0836

• Author Web Link
• Cite
• Citations: 697

Spörri R, Sousa CRE, 2005, Inflammatory mediators are insufficient for full dendritic cell activation and promote expansion of CD4<SUP>+</SUP> T cell populations lacking helper function, NATURE IMMUNOLOGY, Vol: 6, Pages: 163-170, ISSN: 1529-2908

• Author Web Link
• Cite
• Citations: 470

Herre J, Marshall ASJ, Caron E, Edwards AD, Williams DL, Schweighoffer E, Tybulewicz V, Sousa CRE, Gordon S, Brown GDet al., 2004, Dectin-1 uses novel mechanisms for yeast phagocytosis in macrophages, BLOOD, Vol: 104, Pages: 4038-4045, ISSN: 0006-4971

• Author Web Link
• Cite
• Citations: 332

LeibundGut-Landmann S, Waldburger JM, Sousa CRE, Acha-Orbea H, Reith Wet al., 2004, MHC class II expression is differentially regulated in plasmacytoid and conventional dendritic cells, NATURE IMMUNOLOGY, Vol: 5, Pages: 899-908, ISSN: 1529-2908

• Author Web Link
• Cite
• Citations: 107

Diebold SS, Kaisho T, Hemmi H, Akira S, Sousa CREet al., 2004, Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA, SCIENCE, Vol: 303, Pages: 1529-1531, ISSN: 0036-8075

• Author Web Link
• Cite
• Citations: 2591

Sousa CRE, 2004, Toll-like receptors and dendritic cells: for whom the bug tolls, SEMINARS IN IMMUNOLOGY, Vol: 16, Pages: 27-34, ISSN: 1044-5323

• Author Web Link
• Cite
• Citations: 259

Sousa CRE, 2004, Activation of dendritic cells: translating innate into adaptive immunity, CURRENT OPINION IN IMMUNOLOGY, Vol: 16, Pages: 21-25, ISSN: 0952-7915

• Author Web Link
• Cite
• Citations: 269

Ardavín C, Amigorena S, Reis e Sousa C, 2004, Dendritic cells: immunobiology and cancer immunotherapy., Immunity, Vol: 20, Pages: 17-23, ISSN: 1074-7613

A recent workshop on "Dendritic Cells: Biology and Therapeutic Applications," sponsored by the Juan March Foundation, brought together basic and clinical research scientists to discuss the mechanisms underlying the control of immune responses and tolerance by dendritic cells (DCs), as well as recent research in cancer immunotherapy based on DC vaccination. Particular emphasis was placed on antigen processing and presentation by DCs, C-type lectin antigen receptors, DC maturation and polarization of T cell responses, the control of immunity versus tolerance by DCs, the developmental origin of DCs, and the use of DCs in cancer immunotherapy.

• Abstract
• Author Web Link
• Cite

Spörri R, Sousa CR, 2003, Newly activated T cells promote maturation of bystander dendritic cells but not IL-12 production, JOURNAL OF IMMUNOLOGY, Vol: 171, Pages: 6406-6413, ISSN: 0022-1767

• Author Web Link
• Cite
• Citations: 42

Diebold SS, Montoya M, Unger H, Alexopoulou L, Roy P, Haswell LE, Al-Shamkhani A, Flavell R, Borrow P, Sousa CREet al., 2003, Viral infection switches non-plasmacytoid dendritic cells into high interferon producers, NATURE, Vol: 424, Pages: 324-328, ISSN: 0028-0836

• Author Web Link
• Cite
• Citations: 476

Edwards AD, Chaussabel D, Tomlinson S, Schulz O, Sher A, Sousa CREet al., 2003, Relationships among murine CD11c<SUP>high</SUP> dendritic cell subsets as revealed by baseline gene expression patterns, JOURNAL OF IMMUNOLOGY, Vol: 171, Pages: 47-60, ISSN: 0022-1767

• Author Web Link
• Cite
• Citations: 103

Alberti J, Valenzuela JG, Carruthers VB, Hieny S, Andersen J, Charest H, Sousa CRE, Fairlamb A, Ribeiro JM, Sher Aet al., 2003, Molecular mimicry of a CCR5 binding-domain in the microbial activation of dendritic cells, NATURE IMMUNOLOGY, Vol: 4, Pages: 485-490, ISSN: 1529-2908

• Author Web Link
• Cite
• Citations: 181

Edwards AD, Diebold SS, Slack EMC, Tomizawa H, Hemmi H, Kaisho T, Akira S, Sousa CRet al., 2003, Toll-like receptor expression in murine DC subsets:: lack of TLR7 expression by CD8α<SUP>+</SUP> DC correlates with unresponsiveness to imidazoquinolines, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 33, Pages: 827-833, ISSN: 0014-2980

• Author Web Link
• Cite
• Citations: 434

Sousa CR, Diebold SS, Edwards AD, Rogers N, Schulz O, Spörri Ret al., 2003, Regulation of dendritic cell function by microbial stimuli, PATHOLOGIE BIOLOGIE, Vol: 51, Pages: 67-68, ISSN: 0369-8114

• Author Web Link
• Cite
• Citations: 26

Tsujimura H, Tamura T, Gongora C, Aliberti J, Sousa CRE, Sher A, Ozato Ket al., 2003, ICSBP/IRF-8 retrovirus transduction rescues dendritic cell development in vitro, BLOOD, Vol: 101, Pages: 961-969, ISSN: 0006-4971

• Author Web Link
• Cite
• Citations: 95

Aliberti J, Schulz O, Pennington DJ, Tsujimura H, Sousa CRE, Ozato K, Sher Aet al., 2003, Essential role for ICSBP in the in vivo development of murine CD8α<SUP>+</SUP> dendritic cells, BLOOD, Vol: 101, Pages: 305-310, ISSN: 0006-4971

• Author Web Link
• Cite
• Citations: 255

Manickasingham SR, Edwards AD, Schulz O, Sousa CREet al., 2003, The ability of murine dendritic cell subsets to direct T helper cell differentiation is dependent on microbial signals, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 33, Pages: 101-107, ISSN: 0014-2980

• Author Web Link
• Cite
• Citations: 100

Spörri R, Sousa CRE, 2002, Self peptide/MHC class I complexes have a negligible effect on the response of some CD8<SUP>+</SUP> T cells to foreign antigen, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 32, Pages: 3161-3170, ISSN: 0014-2980

• Author Web Link
• Cite
• Citations: 27

Edwards AD, Manickasingham SP, Spörri R, Diebold SS, Schulz O, Sher A, Kaisho T, Akira S, Sousa CREet al., 2002, Microbial recognition via toll-like receptor-dependent and -independent pathways determines the cytokine response of murine dendritic cell subsets to CD40 triggering, JOURNAL OF IMMUNOLOGY, Vol: 169, Pages: 3652-3660, ISSN: 0022-1767

• Author Web Link
• Cite
• Citations: 186

Schulz O, Sousa CRE, 2002, Cross-presentation of cell-associated antigens by CD8α<SUP>+</SUP> dendritic cells is attributable to their ability to internalize dead cells, IMMUNOLOGY, Vol: 107, Pages: 183-189, ISSN: 0019-2805

• Author Web Link
• Cite
• Citations: 163