Publications
147 results found
Kratky W, Reis e Sousa C, Oxenius A, et al., 2011, Direct activation of antigen-presenting cells is required for CD8<SUP>+</SUP> T-cell priming and tumor vaccination, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 108, Pages: 17414-17419, ISSN: 0027-8424
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- Citations: 68
Mourao-Sa D, Robinson MJ, Zelenay S, et al., 2011, CLEC-2 signaling via Syk in myeloid cells can regulate inflammatory responses, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 41, Pages: 3040-3053, ISSN: 0014-2980
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- Citations: 67
Reis e Sousa C, 2011, COUPLING OF DEAD CELL RECOGNITION TO ADAPTIVE IMMUNITY BY DENDRITIC CELLS, 10th World Congress on Inflammation, Publisher: BIRKHAUSER VERLAG AG, Pages: 17-18, ISSN: 1023-3830
Kool M, Willart MAM, van Nimwegen M, et al., 2011, An Unexpected Role for Uric Acid as an Inducer of T Helper 2 Cell Immunity to Inhaled Antigens and Inflammatory Mediator of Allergic Asthma, IMMUNITY, Vol: 34, Pages: 527-540, ISSN: 1074-7613
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- Citations: 267
Reis e Sousa C, 2011, Harnessing dendritic cells, SEMINARS IN IMMUNOLOGY, Vol: 23, Pages: 1-1, ISSN: 1044-5323
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- Citations: 5
Rosas M, Osorio F, Robinson MJ, et al., 2011, Hoxb8 conditionally immortalised macrophage lines model inflammatory monocytic cells with important similarity to dendritic cells, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 41, Pages: 356-365, ISSN: 0014-2980
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- Citations: 23
Franz Poulin L, Salio M, Griessinger E, et al., 2010, Characterization of human DNGR-1<SUP>+</SUP> BDCA3<SUP>+</SUP> leukocytes as putative equivalents of mouse CD8α<SUP>+</SUP> dendritic cells, JOURNAL OF EXPERIMENTAL MEDICINE, Vol: 207, Pages: 1261-1271, ISSN: 0022-1007
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- Citations: 528
Schulz O, Pichlmair A, Rehwinkel J, et al., 2010, Protein Kinase R Contributes to Immunity against Specific Viruses by Regulating Interferon mRNA Integrity, CELL HOST & MICROBE, Vol: 7, Pages: 354-361, ISSN: 1931-3128
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- Citations: 130
Joffre OP, Sancho D, Zelenay S, et al., 2010, Efficient and versatile manipulation of the peripheral CD4<SUP>+</SUP> T-cell compartment by antigen targeting to DNGR-1/CLEC9A, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 40, Pages: 1255-1265, ISSN: 0014-2980
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- Citations: 112
Rehwinkel J, Tan CP, Goubau D, et al., 2010, RIG-I detects viral genomic RNA during negative-strand RNA virus infection., Cell, Vol: 140, Pages: 397-408
RIG-I is a key mediator of antiviral immunity, able to couple detection of infection by RNA viruses to the induction of interferons. Natural RIG-I stimulatory RNAs have variously been proposed to correspond to virus genomes, virus replication intermediates, viral transcripts, or self-RNA cleaved by RNase L. However, the relative contribution of each of these RNA species to RIG-I activation and interferon induction in virus-infected cells is not known. Here, we use three approaches to identify physiological RIG-I agonists in cells infected with influenza A virus or Sendai virus. We show that RIG-I agonists are exclusively generated by the process of virus replication and correspond to full-length virus genomes. Therefore, nongenomic viral transcripts, short replication intermediates, and cleaved self-RNA do not contribute substantially to interferon induction in cells infected with these negative strand RNA viruses. Rather, single-stranded RNA viral genomes bearing 5'-triphosphates constitute the natural RIG-I agonists that trigger cell-intrinsic innate immune responses during infection.
Pichlmair A, Schulz O, Tan C-P, et al., 2009, Activation of MDA5 Requires Higher-Order RNA Structures Generated during Virus Infection, JOURNAL OF VIROLOGY, Vol: 83, Pages: 10761-10769, ISSN: 0022-538X
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- Citations: 344
Robinson MJ, Osorio F, Rosas M, et al., 2009, Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection, Journal of Experimental Medicine, Vol: 206, Pages: 2037-2051, ISSN: 0022-1007
Innate immune cells detect pathogens via pattern recognition receptors (PRRs), which signal for initiation of immune responses to infection. Studies with Dectin-1, a PRR for fungi, have defined a novel innate signaling pathway involving Syk kinase and the adaptor CARD9, which is critical for inducing Th17 responses to fungal infection. We show that another C-type lectin, Dectin-2, also signals via Syk and CARD9, and contributes to dendritic cell (DC) activation by fungal particles. Unlike Dectin-1, Dectin-2 couples to Syk indirectly, through association with the FcRγ chain. In a model of Candida albicans infection, blockade of Dectin-2 did not affect innate immune resistance but abrogated Candida-specific T cell production of IL-17 and, in combination with the absence of Dectin-1, decreased Th1 responses to the organism. Thus, Dectin-2 constitutes a major fungal PRR that can couple to the Syk–CARD9 innate signaling pathway to activate DCs and regulate adaptive immune responses to fungal infection.
Sancho D, Joffre OP, Keller AM, et al., 2009, Identification of a dendritic cell receptor that couples sensing of necrosis to immunity, NATURE, Vol: 458, Pages: 899-903, ISSN: 0028-0836
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- Citations: 528
Kerrigan AM, Dennehy KM, Mourao-Sa D, et al., 2009, CLEC-2 Is a Phagocytic Activation Receptor Expressed on Murine Peripheral Blood Neutrophils, JOURNAL OF IMMUNOLOGY, Vol: 182, Pages: 4150-4157, ISSN: 0022-1767
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- Citations: 93
Hernanz-Falcon P, Joffre O, Williams DL, et al., 2009, Internalization of Dectin-1 terminates induction of inflammatory responses, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 39, Pages: 507-513, ISSN: 0014-2980
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- Citations: 63
Joffre O, Nolte MA, Spoerri R, et al., 2009, Inflammatory signals in dendritic cell activation and the induction of adaptive immunity, IMMUNOLOGICAL REVIEWS, Vol: 227, Pages: 234-247, ISSN: 0105-2896
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- Citations: 425
LeibundGut-Landmann S, Osorio F, Brown GD, et al., 2008, Stimulation of dendritic cells via the dectin-1/Syk pathway allows priming of cytotoxic T-cell responses, BLOOD, Vol: 112, Pages: 4971-4980, ISSN: 0006-4971
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- Citations: 160
Osorio F, LeibundGut-Landmann S, Lochner M, et al., 2008, DC activated <i>via</i> dectin-1 convert Treg into IL-17 producers, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 38, Pages: 3274-3281, ISSN: 0014-2980
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- Citations: 225
Bashyam H, 2008, Caetano Reis e Sousa: harnessing DC power, JOURNAL OF EXPERIMENTAL MEDICINE, Vol: 205, Pages: 1946-1947, ISSN: 0022-1007
Reis e Sousa C, 2008, Innate recognition pathways in dendritic cells, 7th Joint Conference of the International-Cytokine-Society/International-Society-for-Interferon-and-Cytoklin-Research, Publisher: ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD, Pages: 232-232, ISSN: 1043-4666
Sancho D, Mourao-Sa D, Joffre OP, et al., 2008, Tumor therapy in mice via antigen targeting to a novel, DC-restricted C-type lectin, JOURNAL OF CLINICAL INVESTIGATION, Vol: 118, Pages: 2098-2110, ISSN: 0021-9738
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- Citations: 403
Sancho D, Mourão-Sá D, Joffre OP, et al., 2008, Tumor therapy in mice via antigen targeting to a novel, DC-restricted C-type lectin., J Clin Invest, Vol: 118, Pages: 2098-2110, ISSN: 0021-9738
The mouse CD8alpha+ DC subset excels at cross-presentation of antigen, which can elicit robust CTL responses. A receptor allowing specific antigen targeting to this subset and its equivalent in humans would therefore be useful for the induction of antitumor CTLs. Here, we have characterized a C-type lectin of the NK cell receptor group that we named DC, NK lectin group receptor-1 (DNGR-1). DNGR-1 was found to be expressed in mice at high levels by CD8+ DCs and at low levels by plasmacytoid DCs but not by other hematopoietic cells. Human DNGR-1 was also restricted in expression to a small subset of blood DCs that bear similarities to mouse CD8alpha+ DCs. The selective expression pattern and observed endocytic activity of DNGR-1 suggested that it could be used for antigen targeting to DCs. Consistent with this notion, antigen epitopes covalently coupled to an antibody specific for mouse DNGR-1 were selectively cross-presented by CD8alpha+ DCs in vivo and, when given with adjuvants, induced potent CTL responses. When the antigens corresponded to tumor-expressed peptides, treatment with the antibody conjugate and adjuvant could prevent development or mediate eradication of B16 melanoma lung pseudometastases. We conclude that DNGR-1 is a novel, highly specific marker of mouse and human DC subsets that can be exploited for CTL cross-priming and tumor therapy.
Worsley AGF, LeibundGut-Landmann S, Slack E, et al., 2008, Dendritic cell expression of the Notch ligand <i>jagged2</i> is not essential for Th2 response induction <i>in vivo</i>, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 38, Pages: 1043-1049, ISSN: 0014-2980
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- Citations: 39
Pichlmair A, Sousa CRE, 2007, Innate recognition of viruses, IMMUNITY, Vol: 27, Pages: 370-383, ISSN: 1074-7613
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- Citations: 546
Nolte MA, LeibundGut-Landmann S, Joffre O, et al., 2007, Dendritic cell quiescence during systemic inflammation driven by LPS stimulation of radioresistant cells in vivo, JOURNAL OF EXPERIMENTAL MEDICINE, Vol: 204, Pages: 1487-1501, ISSN: 0022-1007
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- Citations: 49
Slack EC, Robinson MJ, Hernanz-Falcon P, et al., 2007, Syk-dependent ERK activation regulates IL-2 and IL-10 production by DC stimulated with zymosan, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 37, Pages: 1600-1612, ISSN: 0014-2980
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- Citations: 134
LeibundGut-Landmann S, Gross O, Robinson MJ, et al., 2007, Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17, NATURE IMMUNOLOGY, Vol: 8, Pages: 630-638, ISSN: 1529-2908
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- Citations: 918
Reis e Sousa C, 2007, Eating in to avoid infection, SCIENCE, Vol: 315, Pages: 1376-1377, ISSN: 0036-8075
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- Citations: 9
Worsley AGF, Leibundgut-Landmon S, Sousa CRE, et al., 2007, Dendritic cells and antigen presentation: why Notch?, Annual Congress of the British-Society-of-Immunology, Publisher: BLACKWELL PUBLISHING, Pages: 59-59, ISSN: 0019-2805
Reis e Sousa C, 2007, Coupling of innate and adaptive immunity via C-type lectin signalling through Syk kinase, Annual Congress of the British-Society-of-Immunology, Publisher: BLACKWELL PUBLISHING, Pages: 22-22, ISSN: 0019-2805
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