Publications
147 results found
Pichlmair A, Diebold SS, Gschmeissner S, et al., 2007, Tubulovesicular structures within vesicular stomatitis virus G protein-pseudotyped lentiviral vector preparations carry DNA and stimulate antiviral responses via toll-like receptor 9, JOURNAL OF VIROLOGY, Vol: 81, Pages: 539-547, ISSN: 0022-538X
- Author Web Link
- Cite
- Citations: 74
Diebold SS, Massacrier C, Akira S, et al., 2006, Nucleic acid agonists for Toll-like receptor 7 are defined by the presence of uridine ribonucleotides., Eur J Immunol, Vol: 36, Pages: 3256-3267, ISSN: 0014-2980
Toll-like receptor 7 (TLR7) mediates innate responses by responding to viral RNA in endocytic compartments. However, the molecular pattern recognised by TLR7 and whether it differs between RNA of viral and self origin remains unclear. Here, we identify nucleic acids that act as TLR7 agonists for mouse and human cells. We show that uridine and ribose, the two defining features of RNA, are both necessary and sufficient for TLR7 stimulation, and that short single-stranded RNA (ssRNA) act as TLR7 agonists in a sequence-independent manner as long as they contain several uridines in close proximity. Consistent with the notion that TLR7 lacks specificity for sequence motifs, we show that it is triggered equally efficiently by viral or self RNA delivered to endosomes. Our results support the notion that TLR7 recognises uracil repeats in RNA and that it discriminates between viral and self ligands on the basis of endosomal accessibility rather than sequence.
Diebold SS, Massacrier C, Akira S, et al., 2006, Nucleic acid agonists for toll-like receptor 7 are defined by the presence of uridine ribonucleotides, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 36, Pages: 3256-3267, ISSN: 0014-2980
- Author Web Link
- Cite
- Citations: 210
Robinson MJ, Sancho D, Slack EC, et al., 2006, Myeloid C-type lectins in innate immunity, NATURE IMMUNOLOGY, Vol: 7, Pages: 1258-1265, ISSN: 1529-2908
- Author Web Link
- Cite
- Citations: 392
Pichlmair A, Schulz O, Tan CP, et al., 2006, RIG-I-mediated antiviral responses to single-stranded RNA bearing 5′-phosphates, SCIENCE, Vol: 314, Pages: 997-1001, ISSN: 0036-8075
- Author Web Link
- Cite
- Citations: 1721
Reis e Sousa C, 2006, Essay - Dendritic cells in a mature age, NATURE REVIEWS IMMUNOLOGY, Vol: 6, Pages: 476-483, ISSN: 1474-1733
- Author Web Link
- Cite
- Citations: 861
Kato H, Takeuchi O, Sato S, et al., 2006, Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses, NATURE, Vol: 441, Pages: 101-105, ISSN: 0028-0836
- Author Web Link
- Cite
- Citations: 2847
Rogers NC, Slack EC, Edwards AD, et al., 2005, Syk-dependent cytokine induction by dectin-1 reveals a novel pattern recognition pathway for C type lectins (vol 22, pg , 2005), IMMUNITY, Vol: 22, Pages: 773-774, ISSN: 1074-7613
- Author Web Link
- Cite
- Citations: 2
Rogers NC, Slack EC, Edwards AD, et al., 2005, Syk-dependent cytokine induction by Dectin-1 reveals a novel pattern recognition pathway for C type lectins, IMMUNITY, Vol: 22, Pages: 507-517, ISSN: 1074-7613
- Author Web Link
- Cite
- Citations: 707
Schulz O, Diebold SS, Chen M, et al., 2005, Toll-like receptor 3 promotes cross-priming to virus-infected cells, NATURE, Vol: 433, Pages: 887-892, ISSN: 0028-0836
- Author Web Link
- Cite
- Citations: 697
Spörri R, Sousa CRE, 2005, Inflammatory mediators are insufficient for full dendritic cell activation and promote expansion of CD4<SUP>+</SUP> T cell populations lacking helper function, NATURE IMMUNOLOGY, Vol: 6, Pages: 163-170, ISSN: 1529-2908
- Author Web Link
- Cite
- Citations: 470
Herre J, Marshall ASJ, Caron E, et al., 2004, Dectin-1 uses novel mechanisms for yeast phagocytosis in macrophages, BLOOD, Vol: 104, Pages: 4038-4045, ISSN: 0006-4971
- Author Web Link
- Cite
- Citations: 332
LeibundGut-Landmann S, Waldburger JM, Sousa CRE, et al., 2004, MHC class II expression is differentially regulated in plasmacytoid and conventional dendritic cells, NATURE IMMUNOLOGY, Vol: 5, Pages: 899-908, ISSN: 1529-2908
- Author Web Link
- Cite
- Citations: 107
Diebold SS, Kaisho T, Hemmi H, et al., 2004, Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA, SCIENCE, Vol: 303, Pages: 1529-1531, ISSN: 0036-8075
- Author Web Link
- Cite
- Citations: 2591
Sousa CRE, 2004, Toll-like receptors and dendritic cells: for whom the bug tolls, SEMINARS IN IMMUNOLOGY, Vol: 16, Pages: 27-34, ISSN: 1044-5323
- Author Web Link
- Cite
- Citations: 259
Sousa CRE, 2004, Activation of dendritic cells: translating innate into adaptive immunity, CURRENT OPINION IN IMMUNOLOGY, Vol: 16, Pages: 21-25, ISSN: 0952-7915
- Author Web Link
- Cite
- Citations: 269
Ardavín C, Amigorena S, Reis e Sousa C, 2004, Dendritic cells: immunobiology and cancer immunotherapy., Immunity, Vol: 20, Pages: 17-23, ISSN: 1074-7613
A recent workshop on "Dendritic Cells: Biology and Therapeutic Applications," sponsored by the Juan March Foundation, brought together basic and clinical research scientists to discuss the mechanisms underlying the control of immune responses and tolerance by dendritic cells (DCs), as well as recent research in cancer immunotherapy based on DC vaccination. Particular emphasis was placed on antigen processing and presentation by DCs, C-type lectin antigen receptors, DC maturation and polarization of T cell responses, the control of immunity versus tolerance by DCs, the developmental origin of DCs, and the use of DCs in cancer immunotherapy.
Spörri R, Sousa CR, 2003, Newly activated T cells promote maturation of bystander dendritic cells but not IL-12 production, JOURNAL OF IMMUNOLOGY, Vol: 171, Pages: 6406-6413, ISSN: 0022-1767
- Author Web Link
- Cite
- Citations: 42
Diebold SS, Montoya M, Unger H, et al., 2003, Viral infection switches non-plasmacytoid dendritic cells into high interferon producers, NATURE, Vol: 424, Pages: 324-328, ISSN: 0028-0836
- Author Web Link
- Cite
- Citations: 476
Edwards AD, Chaussabel D, Tomlinson S, et al., 2003, Relationships among murine CD11c<SUP>high</SUP> dendritic cell subsets as revealed by baseline gene expression patterns, JOURNAL OF IMMUNOLOGY, Vol: 171, Pages: 47-60, ISSN: 0022-1767
- Author Web Link
- Cite
- Citations: 103
Alberti J, Valenzuela JG, Carruthers VB, et al., 2003, Molecular mimicry of a CCR5 binding-domain in the microbial activation of dendritic cells, NATURE IMMUNOLOGY, Vol: 4, Pages: 485-490, ISSN: 1529-2908
- Author Web Link
- Cite
- Citations: 181
Edwards AD, Diebold SS, Slack EMC, et al., 2003, Toll-like receptor expression in murine DC subsets:: lack of TLR7 expression by CD8α<SUP>+</SUP> DC correlates with unresponsiveness to imidazoquinolines, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 33, Pages: 827-833, ISSN: 0014-2980
- Author Web Link
- Cite
- Citations: 434
Sousa CR, Diebold SS, Edwards AD, et al., 2003, Regulation of dendritic cell function by microbial stimuli, PATHOLOGIE BIOLOGIE, Vol: 51, Pages: 67-68, ISSN: 0369-8114
- Author Web Link
- Cite
- Citations: 26
Tsujimura H, Tamura T, Gongora C, et al., 2003, ICSBP/IRF-8 retrovirus transduction rescues dendritic cell development in vitro, BLOOD, Vol: 101, Pages: 961-969, ISSN: 0006-4971
- Author Web Link
- Cite
- Citations: 95
Aliberti J, Schulz O, Pennington DJ, et al., 2003, Essential role for ICSBP in the in vivo development of murine CD8α<SUP>+</SUP> dendritic cells, BLOOD, Vol: 101, Pages: 305-310, ISSN: 0006-4971
- Author Web Link
- Cite
- Citations: 255
Manickasingham SR, Edwards AD, Schulz O, et al., 2003, The ability of murine dendritic cell subsets to direct T helper cell differentiation is dependent on microbial signals, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 33, Pages: 101-107, ISSN: 0014-2980
- Author Web Link
- Cite
- Citations: 100
Spörri R, Sousa CRE, 2002, Self peptide/MHC class I complexes have a negligible effect on the response of some CD8<SUP>+</SUP> T cells to foreign antigen, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 32, Pages: 3161-3170, ISSN: 0014-2980
- Author Web Link
- Cite
- Citations: 27
Edwards AD, Manickasingham SP, Spörri R, et al., 2002, Microbial recognition via toll-like receptor-dependent and -independent pathways determines the cytokine response of murine dendritic cell subsets to CD40 triggering, JOURNAL OF IMMUNOLOGY, Vol: 169, Pages: 3652-3660, ISSN: 0022-1767
- Author Web Link
- Cite
- Citations: 186
Schulz O, Sousa CRE, 2002, Cross-presentation of cell-associated antigens by CD8α<SUP>+</SUP> dendritic cells is attributable to their ability to internalize dead cells, IMMUNOLOGY, Vol: 107, Pages: 183-189, ISSN: 0019-2805
- Author Web Link
- Cite
- Citations: 163
Schulz O, Pennington DJ, Hodivala-Dilke K, et al., 2002, CD36 or αvβ3 and αvβ5 integrins are not essential for MHC class I cross-presentation of cell-associated antigen by CD8α<SUP>+</SUP> murine dendritic cells, JOURNAL OF IMMUNOLOGY, Vol: 168, Pages: 6057-6065, ISSN: 0022-1767
- Author Web Link
- Cite
- Citations: 48
This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.