Imperial College London
Professor Caetano Reis e Sousa

ProfessorCaetanoReis e Sousa

Faculty of Medicine, Department of Immunology and Inflammation

Visiting Professor
 
 
 
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Contact

 

c.reisesousa

 
 
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Location

 

Wright Fleming WingSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Gordon:2018:10.7554/eLife.38636,
author = {Gordon, O and Henry, CM and Srinivasan, N and Ahrens, S and Franz, A and Deddouche, S and Chakravarty, P and Phillips, D and George, R and Kjaer, S and Frith, D and Snijders, AP and Valente, RS and da, Silva CJS and Teixeira, L and Thompson, B and Dionne, MS and Wood, W and Reis, e Sousa C},
doi = {10.7554/eLife.38636},
journal = {eLife},
title = {alpha-actinin accounts for the bioactivity of actin preparations in inducing STAT target genes in Drosophila melanogaster},
url = {http://dx.doi.org/10.7554/eLife.38636},
volume = {7},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Damage-associated molecular patterns (DAMPs) are molecules exposed or released bydead cells that trigger or modulate immunity and tissue repair. In vertebrates, the cytoskeletalcomponent F-actin is a DAMP specifically recognised by DNGR-1, an innate immune receptor.Previously we suggested that actin is also a DAMP in Drosophila melanogaster by inducing STATdependent genes (Srinivasan et al., 2016). Here, we revise that conclusion and report that aactinin is far more potent than actin at inducing the same STAT response and can be found in traceamounts in actin preparations. Recombinant expression of actin or a-actinin in bacteriademonstrated that only a-actinin could drive the expression of STAT target genes in Drosophila.The response to injected a-actinin required the same signalling cascade that we had identified inour previous work using actin preparations. Taken together, these data indicate that a-actininrather than actin drives STAT activation when injected into Drosophila.
AU  - Gordon,O
AU  - Henry,CM
AU  - Srinivasan,N
AU  - Ahrens,S
AU  - Franz,A
AU  - Deddouche,S
AU  - Chakravarty,P
AU  - Phillips,D
AU  - George,R
AU  - Kjaer,S
AU  - Frith,D
AU  - Snijders,AP
AU  - Valente,RS
AU  - da,Silva CJS
AU  - Teixeira,L
AU  - Thompson,B
AU  - Dionne,MS
AU  - Wood,W
AU  - Reis,e Sousa C
DO  - 10.7554/eLife.38636
PY  - 2018///
SN  - 2050-084X
TI  - alpha-actinin accounts for the bioactivity of actin preparations in inducing STAT target genes in Drosophila melanogaster
T2  - eLife
UR  - http://dx.doi.org/10.7554/eLife.38636
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000446156000001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/69292
VL  - 7
ER  -
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