Imperial College London
Professor Caetano Reis e Sousa

ProfessorCaetanoReis e Sousa

Faculty of Medicine, Department of Immunology and Inflammation

Visiting Professor
 
 
 
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Contact

 

c.reisesousa

 
 
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Location

 

Wright Fleming WingSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Boettcher:2018:10.1016/j.cell.2018.01.004,
author = {Boettcher, JP and Bonavita, E and Chakravarty, P and Blees, H and Cabeza-Cabrerizo, M and Sammicheli, S and Rogers, NC and Sahai, E and Zelenay, S and Reis, e Sousa C},
doi = {10.1016/j.cell.2018.01.004},
journal = {Cell},
pages = {1022--1037.e14},
title = {NK cells stimulate recruitment of cDC1 into the tumor microenvironment promoting cancer immune control},
url = {http://dx.doi.org/10.1016/j.cell.2018.01.004},
volume = {172},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Conventional type 1 dendritic cells (cDC1) are critical for antitumor immunity, and their abundance within tumors is associated with immune-mediated rejection and the success of immunotherapy. Here, we show that cDC1 accumulation in mouse tumors often depends on natural killer (NK) cells that produce the cDC1 chemoattractants CCL5 and XCL1. Similarly, in human cancers, intratumoral CCL5, XCL1, and XCL2 transcripts closely correlate with gene signatures of both NK cells and cDC1 and are associated with increased overall patient survival. Notably, tumor production of prostaglandin E2 (PGE2) leads to evasion of the NK cell-cDC1 axis in part by impairing NK cell viability and chemokine production, as well as by causing downregulation of chemokine receptor expression in cDC1. Our findings reveal a cellular and molecular checkpoint for intratumoral cDC1 recruitment that is targeted by tumor-derived PGE2 for immune evasion and that could be exploited for cancer therapy.
AU  - Boettcher,JP
AU  - Bonavita,E
AU  - Chakravarty,P
AU  - Blees,H
AU  - Cabeza-Cabrerizo,M
AU  - Sammicheli,S
AU  - Rogers,NC
AU  - Sahai,E
AU  - Zelenay,S
AU  - Reis,e Sousa C
DO  - 10.1016/j.cell.2018.01.004
EP  - 1037
PY  - 2018///
SN  - 0092-8674
SP  - 1022
TI  - NK cells stimulate recruitment of cDC1 into the tumor microenvironment promoting cancer immune control
T2  - Cell
UR  - http://dx.doi.org/10.1016/j.cell.2018.01.004
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000425937100013&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.sciencedirect.com/science/article/pii/S0092867418300394?via%3Dihub
VL  - 172
ER  -
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