Imperial College London
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DrChristopherRhodes

Faculty of Medicine, National Heart & Lung Institute

Reader in Pulmonary Vascular Disease
 
 
 
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Contact

 

+44 (0)20 7594 7638c.rhodes07

 
 
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Location

 

535ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Wojciak-Stothard:2022:10.1038/s42003-022-04169-z,
author = {Wojciak-Stothard, B and Ainscough, AJ and Smith, TJ and Haensel, M and Rhodes, CJ and Fellows, A and Whitwell, HJ and Vasilaki, E and Grey, K and Freeman, A and Howard, LS and Wharton, J and Dunmore, B and Upton, PD and Wilkins, MR and Edel, J},
doi = {10.1038/s42003-022-04169-z},
journal = {Communications Biology},
pages = {1--15},
title = {An organ-on-chip model of pulmonary arterial hypertension identifies a BMPR2-SOX17-prostacyclin signalling axis},
url = {http://dx.doi.org/10.1038/s42003-022-04169-z},
volume = {5},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Pulmonary arterial hypertension (PAH) is an unmet clinical need. The lack of models of human disease is a key obstacle to drug development. We present a biomimetic model of pulmonary arterial endothelial-smooth muscle cell interactions in PAH, combining natural and induced bone morphogenetic protein receptor 2 (BMPR2) dysfunction with hypoxia to induce smooth muscle activation and proliferation, which is responsive to drug treatment. BMPR2- and oxygenation-specific changes in endothelial and smooth muscle gene expression, consistent with observations made in genomic and biochemical studies of PAH, enable insights into underlying disease pathways and mechanisms of drug response. The model captures key changes in the pulmonary endothelial phenotype that are essential for the induction of SMC remodelling, including a BMPR2-SOX17-prostacyclin signalling axis and offers an easily accessible approach for researchers to study pulmonary vascular remodelling and advance drug development in PAH.
AU  - Wojciak-Stothard,B
AU  - Ainscough,AJ
AU  - Smith,TJ
AU  - Haensel,M
AU  - Rhodes,CJ
AU  - Fellows,A
AU  - Whitwell,HJ
AU  - Vasilaki,E
AU  - Grey,K
AU  - Freeman,A
AU  - Howard,LS
AU  - Wharton,J
AU  - Dunmore,B
AU  - Upton,PD
AU  - Wilkins,MR
AU  - Edel,J
DO  - 10.1038/s42003-022-04169-z
EP  - 15
PY  - 2022///
SN  - 2399-3642
SP  - 1
TI  - An organ-on-chip model of pulmonary arterial hypertension identifies a BMPR2-SOX17-prostacyclin signalling axis
T2  - Communications Biology
UR  - http://dx.doi.org/10.1038/s42003-022-04169-z
UR  - https://www.nature.com/articles/s42003-022-04169-z
UR  - http://hdl.handle.net/10044/1/101160
VL  - 5
ER  -
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