Imperial College London
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DrChristopherRhodes

Faculty of Medicine, National Heart & Lung Institute

Reader in Pulmonary Vascular Disease
 
 
 
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Contact

 

+44 (0)20 7594 7638c.rhodes07

 
 
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Location

 

535ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Rhodes:2017:10.1016/S2213-2600(17)30161-3,
author = {Rhodes, CJ and Wharton, J and Ghataorhe, P and Watson, G and Girerd, B and Howard, LS and Gibbs, JSR and Condliffe, R and Elliot, CA and Kiely, DG and Simonneau, G and Montani, D and Sitbon, O and Gall, H and Schermuly, RT and Ghofrani, HA and Lawrie, A and Humbert, M and Wilkins, MR and Rhodes, CJ and Wharton, J and Ghataorhe, P and Watson, G and Girerd, B and Howard, L and Gibbs, JSR and Condliffe, R and Elliot, C and Kiely, D and Simonneau, G and Montani, D and Sitbon, O and Gall, H and Schermuly, R and Ghofrani, HA and Lawrie, A and Humbert, M and Wilkins, MR},
doi = {10.1016/S2213-2600(17)30161-3},
journal = {Lancet Respiratory Medicine},
pages = {717--726},
title = {Plasma proteome analysis in patients with pulmonary arterial hypertension: an observational cohort study},
url = {http://dx.doi.org/10.1016/S2213-2600(17)30161-3},
volume = {5},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: Idiopathic and heritable pulmonary arterial hypertension form a rare but molecularly heterogeneous disease group. We aimed to measure and validate differences in plasma concentrations of proteins that are associated with survival in patients with idiopathic or heritable pulmonary arterial hypertension to improve risk stratification. METHODS: In this observational cohort study, we enrolled patients with idiopathic or heritable pulmonary arterial hypertension from London (UK; cohorts 1 and 2), Giessen (Germany; cohort 3), and Paris (France; cohort 4). Blood samples were collected at routine clinical appointment visits, clinical data were collected within 30 days of blood sampling, and biochemical data were collected within 7 days of blood sampling. We used an aptamer-based assay of 1129 plasma proteins, and patient clinical details were concealed to the technicians. We identified a panel of prognostic proteins, confirmed with alternative targeted assays, which we evaluated against the established prognostic risk equation for pulmonary arterial hypertension derived from the REVEAL registry. All-cause mortality was the primary endpoint. FINDINGS: 20 proteins differentiated survivors and non-survivors in 143 consecutive patients with idiopathic or heritable pulmonary arterial hypertension with 2 years' follow-up (cohort 1) and in a further 75 patients with 2·5 years' follow-up (cohort 2). Nine proteins were both prognostic independent of plasma NT-proBNP concentrations and confirmed by targeted assays. The functions of these proteins relate to myocardial stress, inflammation, pulmonary vascular cellular dysfunction and structural dysregulation, iron status, and coagulation. A cutoff-based score using the panel of nine proteins provided prognostic information independent of the REVEAL equation, improving the C statistic from area under the curve 0·83 (for REVEAL risk score, 95% CI 0·77-0·89; p<0·0001) to 0·91 (for p
AU  - Rhodes,CJ
AU  - Wharton,J
AU  - Ghataorhe,P
AU  - Watson,G
AU  - Girerd,B
AU  - Howard,LS
AU  - Gibbs,JSR
AU  - Condliffe,R
AU  - Elliot,CA
AU  - Kiely,DG
AU  - Simonneau,G
AU  - Montani,D
AU  - Sitbon,O
AU  - Gall,H
AU  - Schermuly,RT
AU  - Ghofrani,HA
AU  - Lawrie,A
AU  - Humbert,M
AU  - Wilkins,MR
AU  - Rhodes,CJ
AU  - Wharton,J
AU  - Ghataorhe,P
AU  - Watson,G
AU  - Girerd,B
AU  - Howard,L
AU  - Gibbs,JSR
AU  - Condliffe,R
AU  - Elliot,C
AU  - Kiely,D
AU  - Simonneau,G
AU  - Montani,D
AU  - Sitbon,O
AU  - Gall,H
AU  - Schermuly,R
AU  - Ghofrani,HA
AU  - Lawrie,A
AU  - Humbert,M
AU  - Wilkins,MR
DO  - 10.1016/S2213-2600(17)30161-3
EP  - 726
PY  - 2017///
SN  - 2213-2600
SP  - 717
TI  - Plasma proteome analysis in patients with pulmonary arterial hypertension: an observational cohort study
T2  - Lancet Respiratory Medicine
UR  - http://dx.doi.org/10.1016/S2213-2600(17)30161-3
UR  - https://www.sciencedirect.com/science/article/pii/S2213260017301613?via%3Dihub
UR  - http://hdl.handle.net/10044/1/48077
VL  - 5
ER  -
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