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@article{Fleming:2015:10.1183/13993003.00780-2015,
author = {Fleming, L and Murray, C and Bansal, AT and Hashimoto, S and Bisgaard, H and Bush, A and Frey, U and Hedlin, G and Singer, F and van, Aalderen WM and Vissing, NH and Zolkipli, Z and Selby, A and Fowler, S and Shaw, D and Chung, KF and Sousa, AR and Wagers, S and Corfield, J and Pandis, I and Rowe, A and Formaggio, E and Sterk, PJ and Roberts, G},
doi = {10.1183/13993003.00780-2015},
journal = {European Respiratory Journal},
pages = {1322--1333},
title = {The burden of severe asthma in childhood and adolescence: results from the paediatric U-BIOPRED cohorts},
url = {http://dx.doi.org/10.1183/13993003.00780-2015},
volume = {46},
year = {2015}
}

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TY  - JOUR
AB  - U-BIOPRED aims to characterise paediatric and adult severe asthma using conventional and innovative systems biology approaches.A total of 99 school-age children with severe asthma and 81 preschoolers with severe wheeze were compared with 49 school-age children with mild/moderate asthma and 53 preschoolers with mild/moderate wheeze in a cross-sectional study.Despite high-dose treatment, the severe cohorts had more severe exacerbations compared with the mild/moderate ones (annual medians: school-aged 3.0 versus 1.1, preschool 3.9 versus 1.8; p<0.001). Exhaled tobacco exposure was common in the severe wheeze cohort. Almost all participants in each cohort were atopic and had a normal body mass index. Asthma-related quality of life, as assessed by the Paediatric Asthma Quality of Life Questionnaire (PAQLQ) and the Paediatric Asthma Caregiver's Quality of Life Questionnaire (PACQLQ), was worse in the severe cohorts (mean±se school-age PAQLQ: 4.77±0.15 versus 5.80±0.19; preschool PACQLQ: 4.27±0.18 versus 6.04±0.18; both p≤0.001); however, mild/moderate cohorts also had significant morbidity. Impaired quality of life was associated with poor control and airway obstruction. Otherwise, the severe and mild/moderate cohorts were clinically very similar.Children with severe preschool wheeze or severe asthma are usually atopic and have impaired quality of life that is associated with poor control and airflow limitation: a very different phenotype from adult severe asthma. In-depth phenotyping of these children, integrating clinical data with high-dimensional biomarkers, may help to improve and tailor their clinical management.
AU  - Fleming,L
AU  - Murray,C
AU  - Bansal,AT
AU  - Hashimoto,S
AU  - Bisgaard,H
AU  - Bush,A
AU  - Frey,U
AU  - Hedlin,G
AU  - Singer,F
AU  - van,Aalderen WM
AU  - Vissing,NH
AU  - Zolkipli,Z
AU  - Selby,A
AU  - Fowler,S
AU  - Shaw,D
AU  - Chung,KF
AU  - Sousa,AR
AU  - Wagers,S
AU  - Corfield,J
AU  - Pandis,I
AU  - Rowe,A
AU  - Formaggio,E
AU  - Sterk,PJ
AU  - Roberts,G
DO  - 10.1183/13993003.00780-2015
EP  - 1333
PY  - 2015///
SN  - 0903-1936
SP  - 1322
TI  - The burden of severe asthma in childhood and adolescence: results from the paediatric U-BIOPRED cohorts
T2  - European Respiratory Journal
UR  - http://dx.doi.org/10.1183/13993003.00780-2015
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000365454000018&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://erj.ersjournals.com/content/46/5/1322
VL  - 46
ER  -

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