DrCandiceRoufosse

Summary

MD PhD FRCPath

Consultant Renal and Transplant Pathologist since 2007 (50% FTE)

Clinical Senior Lecturer Imperial College since 2018 (50% FTE)

Sub-specialty Lead for Renal and Electron Microscopy, North West London Pathology (Imperial College Healthcare NHS Trust)

Sub-specialty lead for Renal and Transplant Pathology, Royal College of Pathologists (2020-2025)

RESEARCH MISSION

I carry out translational research in the fields of renal and transplant pathology. I apply recent advances in tissue imaging and molecular analysis to improve diagnosis in kidney diseases, for patient and societal benefit. 

I am a clinical trials pathologist and support clinical trials into kidney and transplant disease.

EXPERTISE

Established: renal and transplant pathology; gene expression analysis in diagnostic tissue samples; electron microscopy

Developing: advanced imaging including super-resolution microscopy (with Prof Paul French), advanced ultrastructural examination and correlative microscopy (with Dr Lucy Collinson); digital pathology and machine learning (with Dr Bernhard Kainz)

RECENT RESEARCH HIGH-LIGHTS

I co-lead with Dr Michelle Willicombe the Transplantation subtheme of the Imperial College BRC Immunology theme 2023-2027 (https://imperialbrc.nihr.ac.uk/research/immunology).

Recent Grants

Imperial BRC Core funding: Digital Pathology Initiative - Leica Scanner  

Imperial BRC funding: Clinical Implementation of New Markers of Kidney Disease

Imperial BRC funding: Spatial Transcriptomics for the Investigation of Antibody-Mediated Injury in Kidney Transplants 

NIHR Capital Investment Call - GPU Workstations for Digital Pathology

Imperial Confidence in Concepts (ICiC). Development of an ICL - RMH/ICR pipeline for integrated development and deployment of tissue-based AI

MRC Multimodal Multiscale Initiative. A Nanopathology Platform for Prediction and Early Detection of Disease in Kidney Transplant Rejection. 

North West London Pathology (NWLP) Education- Research Co-ordination Funding: Establishing a Platform for Embedding Deep Learning Algorithms in Diagnostic Cellular Pathology workflows

Kidney Research UK Training Fellowship: Improving our understanding of auto-immunity following kidney transplantation: biomarkers, outcomes and the link with alloimmunity (Dr Gleeson) 

Named collaborator on: “Democratisation of Visual Proteomics via HR-CLEM-KIT, a low cost user-friendly high-resolution CLEM pipeline. “ Chan-Zuckerberg Initiative Grant

Auchi Fund Imperial Health Charity: The Role of Spleen Tyrosine Kinase in Renal Allograft Rejection (Dr Clarke) and Novel biomarkers in antibody-mediated rejection of the transplanted kidney” (Dr Beadle)

Novel imaging of kidney disease

Imperial Confidence in Concept (ICiC): Novel, low-cost instrumentation for clinical histopathology of kidney disease [PI Paul French Photonics Group, Physics Department]

RECENT PUBLICATION HIGH-LIGHTS

Biopsy-based transcriptomics in the diagnosis of kidney transplant rejection. de Nattes T, Beadle J, Roufosse C.Curr Opin Nephrol Hypertens. 2024 Feb 22. doi: 10.1097/MNH.0000000000000974. PMID: 38411022

Application of HLA molecular level mismatching in ethnically diverse kidney transplant recipients receiving a steroid sparing immunosuppression protocol. Santos E, Spensley K, Gunby N, Worthington J, Roufosse C, Anand A, Willicombe M.Am J Transplant. 2024 Feb 23:S1600-6135(24)00161-8. doi: 10.1016/j.ajt.2024.02.019. PMID: 38403189 

 Atypical Anti-Glomerular Basement Membrane Nephritis: A Case Series From the French Nephropathology Group. Chauveau B, Gibier JB, Olagne J, Morel A, Aydin S, McAdoo SP, Viallet N, Perrochia H, Pambrun E, Royal V, Demoulin N, Kemeny JL, Philipponnet C, Hertig A, Boffa JJ, Plaisier E, Domenger C, Brochériou I, Deltombe C, Duong Van Huyen JP, Buob D, Roufosse C, Hellmark T, Audard V, Mihout F, Nasr SH, Renaudin K, Moktefi A, Rabant M; CFPR - French Nephropathology Group.Am J Kidney Dis. 2024 Jan 1:S0272-6386(23)01003-X. doi: 10.1053/j.ajkd.2023.11.003.

Randomized Trial on the Effect of an Oral Spleen Tyrosine Kinase Inhibitor in the Treatment of IgA Nephropathy. Tam FWK, Tumlin J, Barratt J, Rovin BH, Roberts ISD, Roufosse C, Cook HT, Bhangal G, Brown AL, Busch M, Dudhiya F, Duliege AM, Fraser DJ, Gale DP, Huang CC, Lai PC, Lee M, Masuda ES, McAdoo SP, Rosenkranz AR, Sommerer C, Sunder-Plassmann G, Szeto CC, Tang SCW, Williamson DE, Willcocks L, Vielhauer V, Kim MJ, Todd L, Zayed H, Tong-Starksen S, Lafayette R. Kidney Int Rep. 2023 Sep 30;8(12):2546-2556. doi: 10.1016/j.ekir.2023.09.024. PMID: 38106605 

The Banff 2022 Kidney Meeting Report: Reappraisal of microvascular inflammation and the role of biopsy-based transcript diagnostics. Naesens M, Roufosse C, Haas M, Lefaucheur C, Mannon RB, Adam BA, Aubert O, Böhmig GA, Callemeyn J, Clahsen-van Groningen M, Cornell LD, Demetris AJ, Drachenberg CB, Einecke G, Fogo AB, Gibson IW, Halloran P, Hidalgo LG, Horsfield C, Huang E, Kikić Ž, Kozakowski N, Nankivell B, Rabant M, Randhawa P, Riella LV, Sapir-Pichhadze R, Schinstock C, Solez K, Tambur AR, Thaunat O, Wiebe C, Zielinski D, Colvin R, Loupy A, Mengel M.Am J Transplant. 2024 Mar;24(3):338-349. doi: 10.1016/j.ajt.2023.10.016. PMID: 38032300  

The Banff 2022 Kidney Meeting Work Plan: Data-driven refinement of the Banff Classification for renal allografts. Roufosse C, Naesens M, Haas M, Lefaucheur C, Mannon RB, Afrouzian M, Alachkar N, Aubert O, Bagnasco SM, Batal I, Bellamy COC, Broecker V, Budde K, Clahsen-Van Groningen M, Coley SM, Cornell LD, Dadhania D, Demetris AJ, Einecke G, Farris AB, Fogo AB, Friedewald J, Gibson IW, Horsfield C, Huang E, Husain SA, Jackson AM, Kers J, Kikić Ž, Klein A, Kozakowski N, Liapis H, Mangiola M, Montgomery RA, Nankinvell B, Neil DAH, Nickerson P, Rabant M, Randhawa P, Riella LV, Rosales I, Royal V, Sapir-Pichhadze R, Sarder P, Sarwal M, Schinstock C, Stegall M, Solez K, van der Laak J, Wiebe C, Colvin RB, Loupy A, Mengel M.Am J Transplant. 2024 Mar;24(3):350-361. doi: 10.1016/j.ajt.2023.10.031. PMID: 37931753 

 

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