Imperial College London
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DrCandiceRoufosse

Faculty of Medicine, Department of Immunology and Inflammation

Clinical Reader in Renal Pathology
 
 
 
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Contact

 

+44 (0)20 3313 3280c.roufosse

 
 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Mengel:2020:10.1111/ajt.16059,
author = {Mengel, M and Loupy, A and Haas, M and Roufosse, C and Naesens, M and Akalin, E and Clahsen-van, Groningen MC and J, Dagobert and Demetris, AJ and Duong, van Huyen JP and Gueguen, J and Issa, F and Robin, B and Rosales, I and Von, der Thüsen JH and Sanchez-Fueyo, A and Smith, RN and Wood, K and Adam, B and Colvin, RB},
doi = {10.1111/ajt.16059},
journal = {American Journal of Transplantation},
title = {Banff 2019 Meeting Report: Molecular diagnostics in solid organ transplantation - Consensus for the Banff Human Organ Transplant (B-HOT) gene panel and open source multicenter validation},
url = {http://dx.doi.org/10.1111/ajt.16059},
volume = {20},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - This Meeting Report from the XVth Banff conference describes the creation of a multi-organ transplant gene panel by the Banff Molecular Diagnostics Working Group (MDWG). This Banff Human Organ Transplant (B-HOT) panel is the culmination of previous work by the MDWG to identify a broadly useful gene panel based on whole transcriptome technology. A data driven process distilled a gene list from peer reviewed comprehensive microarray studies that discovered and validated their use in kidney, liver, heart and lung transplant biopsies. These were supplemented by genes that define relevant cellular pathways and cell types plus 12 reference genes used for normalization. The 770 gene B-HOT panel includes the most pertinent genes related to rejection, tolerance, viral infections, and innate and adaptive immune responses. This commercially available panel uses the NanoString platform, which can quantitate transcripts from formalin fixed paraffin embedded samples. The B-HOT panel will facilitate multicenter collaborative clinical research using archival samples and permit the development of an open source large database of standardized analyzes, thereby expediting clinical validation studies. The MDWG believes that a pathogenesis and pathway based molecular approach will be valuable for investigators and promote therapeutic decision-making and clinical trials.
AU  - Mengel,M
AU  - Loupy,A
AU  - Haas,M
AU  - Roufosse,C
AU  - Naesens,M
AU  - Akalin,E
AU  - Clahsen-van,Groningen MC
AU  - J,Dagobert
AU  - Demetris,AJ
AU  - Duong,van Huyen JP
AU  - Gueguen,J
AU  - Issa,F
AU  - Robin,B
AU  - Rosales,I
AU  - Von,der Thüsen JH
AU  - Sanchez-Fueyo,A
AU  - Smith,RN
AU  - Wood,K
AU  - Adam,B
AU  - Colvin,RB
DO  - 10.1111/ajt.16059
PY  - 2020///
SN  - 1600-6135
TI  - Banff 2019 Meeting Report: Molecular diagnostics in solid organ transplantation - Consensus for the Banff Human Organ Transplant (B-HOT) gene panel and open source multicenter validation
T2  - American Journal of Transplantation
UR  - http://dx.doi.org/10.1111/ajt.16059
UR  - https://www.ncbi.nlm.nih.gov/pubmed/32428337
UR  - https://onlinelibrary.wiley.com/doi/abs/10.1111/ajt.16059
UR  - http://hdl.handle.net/10044/1/79596
VL  - 20
ER  -
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