Imperial College London
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DrCandiceRoufosse

Faculty of Medicine, Department of Immunology and Inflammation

Clinical Reader in Renal Pathology
 
 
 
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Contact

 

+44 (0)20 3313 3280c.roufosse

 
 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Kapp:2021:10.1097/MAT.0000000000001530,
author = {Kapp, ME and Fogo, AB and Roufouse, C and Najafian, B and Radhakrishnan, J and Mohan, S and Miller, SE and D'Agati, VD and Silberzweig, J and Barbar, T and Gopalan, T and Srivatana, V and Mokrzycki, MH and Benstein, JA and Ng, Y-H and Lentine, KL and Aggarwal, V and Perl, J and Salenger, P and Koyner, JL and Josephson, MA and Heung, M and Velez, JC and Ikizler, A and Vijayan, A and William, P and Thajudeen, B and Slepian, MJ},
doi = {10.1097/MAT.0000000000001530},
journal = {ASAIO J},
pages = {1087--1096},
title = {Renal Considerations in COVID-19: Biology, Pathology, and Pathophysiology.},
url = {http://dx.doi.org/10.1097/MAT.0000000000001530},
volume = {67},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has emerged into a worldwide pandemic of epic proportion. Beyond pulmonary involvement in coronavirus disease 2019 (COVID-19), a significant subset of patients experiences acute kidney injury. Patients who die from severe disease most notably show diffuse acute tubular injury on postmortem examination with a possible contribution of focal macro- and microvascular thrombi. Renal biopsies in patients with proteinuria and hematuria have demonstrated a glomerular dominant pattern of injury, most notably a collapsing glomerulopathy reminiscent of findings seen in human immunodeficiency virus (HIV) in individuals with apolipoprotein L-1 (APOL1) risk allele variants. Although various mechanisms have been proposed for the pathogenesis of acute kidney injury in SARS-CoV-2 infection, direct renal cell infection has not been definitively demonstrated and our understanding of the spectrum of renal involvement remains incomplete. Herein we discuss the biology, pathology, and pathogenesis of SARS-CoV-2 infection and associated renal involvement. We discuss the molecular biology, risk factors, and pathophysiology of renal injury associated with SARS-CoV-2 infection. We highlight the characteristics of specific renal pathologies based on native kidney biopsy and autopsy. Additionally, a brief discussion on ancillary studies and challenges in the diagnosis of SARS-CoV-2 is presented.
AU  - Kapp,ME
AU  - Fogo,AB
AU  - Roufouse,C
AU  - Najafian,B
AU  - Radhakrishnan,J
AU  - Mohan,S
AU  - Miller,SE
AU  - D'Agati,VD
AU  - Silberzweig,J
AU  - Barbar,T
AU  - Gopalan,T
AU  - Srivatana,V
AU  - Mokrzycki,MH
AU  - Benstein,JA
AU  - Ng,Y-H
AU  - Lentine,KL
AU  - Aggarwal,V
AU  - Perl,J
AU  - Salenger,P
AU  - Koyner,JL
AU  - Josephson,MA
AU  - Heung,M
AU  - Velez,JC
AU  - Ikizler,A
AU  - Vijayan,A
AU  - William,P
AU  - Thajudeen,B
AU  - Slepian,MJ
DO  - 10.1097/MAT.0000000000001530
EP  - 1096
PY  - 2021///
SP  - 1087
TI  - Renal Considerations in COVID-19: Biology, Pathology, and Pathophysiology.
T2  - ASAIO J
UR  - http://dx.doi.org/10.1097/MAT.0000000000001530
UR  - https://www.ncbi.nlm.nih.gov/pubmed/34191753
VL  - 67
ER  -
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