Imperial College London
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DrChristopherRowlands

Faculty of Engineering, Department of Bioengineering

Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 1331c.rowlands Website CV

 
 
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Location

 

3.15Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Bezer:2020:10.1016/j.ultrasmedbio.2020.08.012,
author = {Bezer, JH and Koruk, H and Rowlands, CJ and Choi, JJ},
doi = {10.1016/j.ultrasmedbio.2020.08.012},
journal = {Ultrasound in Medicine and Biology},
pages = {3327--3338},
title = {Elastic deformation of soft tissue-mimicking materials using a single microbubble and acoustic radiation force},
url = {http://dx.doi.org/10.1016/j.ultrasmedbio.2020.08.012},
volume = {46},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Mechanical effects of microbubbles on tissues are central to many emerging ultrasound applications. Here, we investigated the acoustic radiation force a microbubble exerts on tissue at clinically relevant therapeutic ultrasound parameters. Individual microbubbles administered into a wall-less hydrogel channel (diameter: 25-100 µm, Young's modulus: 2-8.7 kPa) were exposed to an acoustic pulse (centre frequency: 1 MHz, pulse length: 10 ms, peak-rarefactional pressures: 0.6-1.0 MPa). Using high-speed microscopy, each microbubble was tracked as it pushed against the hydrogel wall. We found that a single microbubble can transiently deform a soft tissue-mimicking material by several micrometres, producing tissue loading-unloading curves that were similar to those produced using other indentation-based methods. Indentation depths were linked to gel stiffness. Using a mathematical model fitted to the deformation curves, we estimated the radiation force on each bubble (typically tens of nanonewtons) and the viscosity of the gels. These results provide insight into the forces exerted on tissues during ultrasound therapy and indicate a potential source of bio-effects.
AU  - Bezer,JH
AU  - Koruk,H
AU  - Rowlands,CJ
AU  - Choi,JJ
DO  - 10.1016/j.ultrasmedbio.2020.08.012
EP  - 3338
PY  - 2020///
SN  - 0301-5629
SP  - 3327
TI  - Elastic deformation of soft tissue-mimicking materials using a single microbubble and acoustic radiation force
T2  - Ultrasound in Medicine and Biology
UR  - http://dx.doi.org/10.1016/j.ultrasmedbio.2020.08.012
UR  - https://www.ncbi.nlm.nih.gov/pubmed/32919812
UR  - http://hdl.handle.net/10044/1/84818
VL  - 46
ER  -
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