Imperial College London
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Dr Charlotte-Eve Short

Faculty of Medicine, Department of Infectious Disease

Academic Clinical Lecturer
 
 
 
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Contact

 

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Location

 

VD4, Variety wingNorfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Charlton:2014:10.1002/pd.4267,
author = {Charlton, TG and Franklin, JM and Douglas, M and Short, CE and Mills, I and Smith, R and Clarke, A and Smith, J and Tookey, PA and Cortina-Borja, M and Taylor, GP},
doi = {10.1002/pd.4267},
journal = {Prenatal Diagnosis},
pages = {121--127},
title = {The impact of HIV infection and antiretroviral therapy on the predicted risk of Down syndrome},
url = {http://dx.doi.org/10.1002/pd.4267},
volume = {34},
year = {2014}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - ObjectiveThe aim of this study was to assess predicted Down syndrome risk, based on three serum analytes (triple test), with HIV infection status and antiretroviral therapy regimen.MethodsScreening results in 72 HIVpositive women were compared with results from agematched and racematched HIVnegative controls. Mean concentrations of each analyte were compared by serostatus and antiretroviral therapy. Observed Down syndrome incidence in the offspring of HIVpositive women was calculated from national HIV surveillance data.ResultsOverall, women with HIV had a significantly higher probability of receiving a ‘highrisk’ result than uninfected controls (p = 0.002). Compared with matched uninfected controls, women with HIV infection had significantly higher human chorionic gonadotrophin, lower unconjugated estriol, and higher overall predicted risk of their infant having Down syndrome (1/6250 vs. 1/50 000 p = < 0.001). National surveillance data show no evidence of higher than expected incidence of Down syndrome in the offspring of HIVpositive women.ConclusionsHIV infection impacts the serum analytes used to assay for Down syndrome risk resulting in a high rate of ‘high risk’ results. However, there is no populationbased association between maternal HIV infection and Down syndrome. Care should be taken when interpreting highrisk serum screening results in HIVpositive women to avoid unnecessary invasive diagnostic procedures. © 2013 John Wiley & Sons, Ltd.
AU  - Charlton,TG
AU  - Franklin,JM
AU  - Douglas,M
AU  - Short,CE
AU  - Mills,I
AU  - Smith,R
AU  - Clarke,A
AU  - Smith,J
AU  - Tookey,PA
AU  - Cortina-Borja,M
AU  - Taylor,GP
DO  - 10.1002/pd.4267
EP  - 127
PY  - 2014///
SN  - 0197-3851
SP  - 121
TI  - The impact of HIV infection and antiretroviral therapy on the predicted risk of Down syndrome
T2  - Prenatal Diagnosis
UR  - http://dx.doi.org/10.1002/pd.4267
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000331249600004&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://obgyn.onlinelibrary.wiley.com/doi/full/10.1002/pd.4267
VL  - 34
ER  -
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