My research focused on the role of hypothalamic peptides in the control of energy homeostasis and body weight regulation. It investigated the links between energy homeostasis and metabolic function, particularly the control of the thyroid and reproduction. The research extended into how the gut sensed nutritional status and signalled to the appetite centers of the brain to regulate food intake.
Researched focused on two gut hormones, Peptide YY (PYY) and Oxyntomudulin and how these gut hormones controlled food intake and body weight. Following a number of studies in rodents and humans trials these discoveries were patented and formed the basis of the Imperial spin out company Thiakis. This lead my focus into the comercial side of Imperial as Divisional Comercialisation Director and in 2007 I completed the Exec MBA programme at Imperial Colege Business School.
During 2014 I undertook a project as part of REF assessment excercise. I wrote the Impact Case studies for the Faculty of Medicine demonstrating the depth and breath of the research at Imperial. I continue to teach the undergraduate medical students at Imperial.
et al., 2009, Coordinated changes in energy intake and expenditure following hypothalamic administration of neuropeptides involved in energy balance, International Journal of Obesity, Vol:33, ISSN:0307-0565, Pages:775-785
et al., 2008, PYY3-36 injection in mice produces an acute anorexigenic effect followed by a delayed orexigenic effect not observed with other anorexigenic gut hormones, American Journal of Physiology-endocrinology and Metabolism, Vol:294, ISSN:0193-1849, Pages:E698-E708
et al., 2008, Co-administration of SR141716 with peptide YY3-36 or oxyntomodulin has additive effects on food intake in mice, Diabetes Obesity & Metabolism, Vol:10, ISSN:1462-8902, Pages:167-170
et al., 2007, The temporal sequence of gut Peptide-CNS interactions tracked in vivo by magnetic resonance Imaging, Journal of Neuroscience, Vol:27, ISSN:0270-6474, Pages:12341-12348
et al., 2007, Low-dose oral tri-iodothyronine does not directly increase food intake in man, Diabetes Obesity & Metabolism, Vol:9, ISSN:1462-8902, Pages:435-437