Imperial College London

DrCarolineSmall

Faculty of MedicineDepartment of Metabolism, Digestion and Reproduction

Honorary Senior Lecturer
 
 
 
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Contact

 

c.small Website

 
 
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Location

 

Metabolic MedicineCommonwealth BuildingHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

92 results found

Semjonous NM, Smith KL, Parkinson JRC, Gunner DJL, Liu Y-L, Murphy KG, Ghatei MA, Bloom SR, Small CJet al., 2009, Coordinated changes in energy intake and expenditure following hypothalamic administration of neuropeptides involved in energy balance, International Journal of Obesity, Vol: 33, Pages: 775-785, ISSN: 0307-0565

Journal article

Parkinson JRC, Dhillo WS, Small CJ, Chaudhri OB, Bewick GA, Pritchard I, Moore S, Ghatei MA, Bloom SRet al., 2008, PYY<sub>3-36</sub> injection in mice produces an acute anorexigenic effect followed by a delayed orexigenic effect not observed with other anorexigenic gut hormones, AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, Vol: 294, Pages: E698-E708, ISSN: 0193-1849

Journal article

White NE, Dhillo WS, Liu Y-L, Small CJ, Kennett GA, Gardiner JV, Ghatei MA, Bloom SRet al., 2008, Co-administration of SR141716 with peptide YY<sub>3-36</sub> or oxyntomodulin has additive effects on food intake in mice, DIABETES OBESITY & METABOLISM, Vol: 10, Pages: 167-170, ISSN: 1462-8902

Journal article

Kuo Y-T, Parkinson JRC, Chaudhri OB, Herlihy AH, So P-W, Dhillo WS, Small CJ, Bloom SR, Bell JDet al., 2007, The temporal sequence of gut Peptide-CNS interactions tracked <i>in vivo</i> by magnetic resonance Imaging, JOURNAL OF NEUROSCIENCE, Vol: 27, Pages: 12341-12348, ISSN: 0270-6474

Journal article

Martin NM, Small CJ, Lee JL, Ellis S, Dhillo WS, Smith KL, Kong WM, Frost GS, Bloom SRet al., 2007, Low-dose oral tri-iodothyronine does not directly increase food intake in man, DIABETES OBESITY & METABOLISM, Vol: 9, Pages: 435-437, ISSN: 1462-8902

Journal article

Jesudason DR, Monteiro MP, McGowan BMC, Neary NM, Park AJ, Philippou E, Small CJ, Frost GS, Ghatei MA, Bloom SRet al., 2007, Low-dose pancreatic polypeptide inhibits food intake in man, BRITISH JOURNAL OF NUTRITION, Vol: 97, Pages: 426-429, ISSN: 0007-1145

Journal article

Wynne K, Park AJ, Small CJ, Meeran K, Ghatei MA, Frost GS, Bloom SRet al., 2006, Oxyntomodulin increases energy expenditure in addition to decreasing energy intake in overweight and obese humans: a randomised controlled trial, INTERNATIONAL JOURNAL OF OBESITY, Vol: 30, Pages: 1729-1736, ISSN: 0307-0565

Journal article

McGowan BM, Stanley SA, Smith KL, Minnion JS, Donovan J, Thompson EL, Patterson M, Connolly MM, Abbott CR, Small CJ, Gardiner JV, Ghatel MA, Bloom SRet al., 2006, Effects of acute and chronic relaxin-3 on food intake and energy expenditure in rats, REGULATORY PEPTIDES, Vol: 136, Pages: 72-77, ISSN: 0167-0115

Journal article

Jethwa PH, Smith KL, Small CJ, Abbott CR, Darch SJ, Murphy KG, Seth A, Semjonous NM, Patel SR, Todd JF, Ghatei MA, Bloom SRet al., 2006, Neuromedin U partially mediates leptin-induced hypothalamo-pituitary adrenal (HPA) stimulation and has a physiological role in the regulation of the HPA axis in the rat, ENDOCRINOLOGY, Vol: 147, Pages: 2886-2892, ISSN: 0013-7227

Journal article

Murray JF, Hahn JD, Kennedy AR, Small CJ, Bloom SR, Haskell-Luevano C, Coen CW, Wilson CAet al., 2006, Evidence for a stimulatory action of melanin-concentrating hormone on luteinising hormone release involving MCH1 and melanocortin-5 receptors, JOURNAL OF NEUROENDOCRINOLOGY, Vol: 18, Pages: 157-167, ISSN: 0953-8194

Journal article

Martin NM, Houston PA, Patterson M, Sajedi A, Carmignac DF, Ghatei MA, Bloom SR, Small CJet al., 2006, Abnormalities of the somatotrophic axis in the obese agouti mouse, INTERNATIONAL JOURNAL OF OBESITY, Vol: 30, Pages: 430-438, ISSN: 0307-0565

Journal article

Abbott CR, Small CJ, Sajedi A, Smith KL, Parkinson JRC, Broadhead LL, Ghatei MA, Bloom SRet al., 2006, The importance of acclimatisation and habituation to experimental conditions when investigating the anorectic effects of gastrointestinal hormones in the rat, INTERNATIONAL JOURNAL OF OBESITY, Vol: 30, Pages: 288-292, ISSN: 0307-0565

Journal article

Martin NM, Smith KL, Bloom SR, Small CJet al., 2006, Interactions between the melanocortin system and the hypothalamo-pituitary-thyroid axis, PEPTIDES, Vol: 27, Pages: 333-339, ISSN: 0196-9781

Journal article

Druce MR, Neary NM, Small CJ, Milton J, Monteiro M, Patterson M, Ghatei MA, Bloom SRet al., 2006, Subcutaneous administration of ghrelin stimulates energy intake in healthy lean human volunteers, INTERNATIONAL JOURNAL OF OBESITY, Vol: 30, Pages: 293-296, ISSN: 0307-0565

Journal article

Neary NM, Druce MR, Small CJ, Bloom SRet al., 2006, Acylated ghrelin stimulates food intake in the fed and fasted states but desacylated ghrelin has no effect, GUT, Vol: 55, Pages: 135-135, ISSN: 0017-5749

Journal article

Neary NM, Small CJ, Druce MR, Park AJ, Ellis SM, Semjonous NM, Dakin CL, Filipsson K, Wang F, Kent AS, Frost GS, Ghatei MA, Bloom SRet al., 2005, Peptide YY<sub>3-36</sub> and glucagon-like peptide-1<sub>7-36</sub> inhibit food intake additively, ENDOCRINOLOGY, Vol: 146, Pages: 5120-5127, ISSN: 0013-7227

Journal article

Jethwa PH, Small CJ, Smith KL, Seth A, Darch SJ, Abbott CR, Murphy KG, Todd JF, Ghatei MA, Bloom SRet al., 2005, Neuromedin U has a physiological role in the regulation of food intake and partially mediates the effects of leptin, AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, Vol: 289, Pages: E301-E305, ISSN: 0193-1849

Journal article

Wynne K, Park AJ, Small CJ, Patterson M, Ellis SM, Murphy KG, Wren AM, Frost GS, Meeran K, Ghatei MA, Bloom SRet al., 2005, Subcutaneous oxyntomodulin reduces body weight in overweight and obese subjects - A double-blind, randomized, controlled trial, DIABETES, Vol: 54, Pages: 2390-2395, ISSN: 0012-1797

Journal article

le Roux CW, Neary NM, Halsey TJ, Small CJ, Martinez-Isla AM, Ghatei MA, Theodorou NA, Bloom SRet al., 2005, Ghrelin does not stimulate food intake in patients with surgical procedures involving vagotomy, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol: 90, Pages: 4521-4524, ISSN: 0021-972X

Journal article

Wynne K, Giannitsopoulou K, Small CJ, Patterson M, Frost G, Ghatei MA, Brown EA, Bloom SR, Choi Pet al., 2005, Subcutaneous ghrelin enhances acute food intake in malnourished patients who receive maintenance peritoneal dialysis: A randomized, placebo-controlled trial, JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, Vol: 16, Pages: 2111-2118, ISSN: 1046-6673

Journal article

Abbott CR, Monteiro M, Small CJ, Sajedi A, Smith KL, Parkinson JRC, Ghatei MA, Bloom SRet al., 2005, The inhibitory effects of peripheral administration of peptide YY<sub>3-36</sub> and glucagon-like peptide-1 on food intake are attenuated by ablation of the vagal-brainstem-hypothalamic pathway, BRAIN RESEARCH, Vol: 1044, Pages: 127-131, ISSN: 0006-8993

Journal article

Abbott CR, Small CJ, Kennedy AR, Neary NM, Sajedi A, Ghatei MA, Bloom SRet al., 2005, Blockade of the neuropeptide YY2 receptor with the specific antagonist BIIE0246 attenuates the effect of endogenous and exogenous peptide YY<sub>(3-36)</sub> on food intake, BRAIN RESEARCH, Vol: 1043, Pages: 139-144, ISSN: 0006-8993

Journal article

Small CJ, Bloom SR, 2005, The therapeutic potential of gut hormone peptide YY<sub>3-36</sub> in the treatment of obesity, EXPERT OPINION ON INVESTIGATIONAL DRUGS, Vol: 14, Pages: 647-653, ISSN: 1354-3784

Journal article

Andersson U, Treebak JT, Nielsen JN, Smith KL, Abbott CR, Small CJ, Carling D, Richter EAet al., 2005, Exercise in rats does not alter hypothalamic AMP-activated protein kinase activity, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol: 329, Pages: 719-725, ISSN: 0006-291X

Journal article

Small CJ, Parkinson JR, Bloom SR, 2005, Novel therapeutic targets for appetite regulation., Curr Opin Investig Drugs, Vol: 6, Pages: 369-372, ISSN: 1472-4472

Obesity is currently the major cause of premature death in the UK, killing almost 1000 individuals per week, and worldwide, its prevalence is accelerating. Many peptides are synthesized and released from the gastrointestinal tract and, while their roles in the regulation of gastrointestinal function have been known for some time, it is now evident that they also physiologically influence eating behavior. Therefore, manipulation of gastrointestinal hormones provides the prospect of an effective and well-tolerated treatment for obesity. Whereas drugs targeting appetite-signaling neuropeptides in the brain may also affect other aspects of the central nervous system, agents based on gut hormones themselves have the advantage of targeting specific appetite circuits within the brain without producing any unacceptable side effects.

Journal article

Martin NM, Small CJ, Sajedi A, Liao XH, Weiss RE, Gardiner JV, Ghatei MA, Bloom SRet al., 2004, Abnormalities of the hypothalamo-pituitary-thyroid axis in the pro-opiomelanocortin deficient mouse, REGULATORY PEPTIDES, Vol: 122, Pages: 169-172, ISSN: 0167-0115

Journal article

Thompson EL, Murphy KG, Todd JF, Martin NM, Small CJ, Ghatei MA, Bloom SRet al., 2004, Chronic administration of NMU into the paraventricular nucleus stimulates the HPA axis but does not influence food intake or body weight, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol: 323, Pages: 65-71, ISSN: 0006-291X

Journal article

Small CJ, Bloom SR, 2004, Gut hormones and the control of appetite, TRENDS IN ENDOCRINOLOGY AND METABOLISM, Vol: 15, Pages: 259-263, ISSN: 1043-2760

Journal article

Batterham RL, Cowley MA, Small CJ, Herzog H, Cohen MA, Dakin CL, Wren AM, Brynes AE, Low MJ, Ghatei MA, Cone RD, Bloom SRet al., 2004, Does gut hormone PYY<sub>3-36</sub> decrease food intake in rodents?: Reply, NATURE, Vol: 430, ISSN: 0028-0836

Journal article

Martin NM, Small CJ, Sajedi A, Patterson M, Ghatei MA, Bloom SRet al., 2004, Pre-obese and obese agouti mice are sensitive to the anorectic effects of peptide YY<sub>3-36</sub> but resistant to ghrelin, INTERNATIONAL JOURNAL OF OBESITY, Vol: 28, Pages: 886-893, ISSN: 0307-0565

Journal article

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