Imperial College London
Portrait Picture

DrChristopher BernhardTimmermann Slater

Faculty of Medicine, Department of Brain Sciences

Research Associate
 
 
 
//

Contact

 

+44 (0)20 7594 7994c.timmermann-slater15 CV

 
 
//

Location

 

Burlington DanesHammersmith Campus

//

Summary

 

Publications

Citation

BibTex format

@unpublished{Timmermann:2019:10.1101/706283,
author = {Timmermann, C and Roseman, L and Schartner, M and Milliere, R and Williams, L and Erritzoe, D and Muthukumaraswamy, S and Ashton, M and Bendrioua, A and Kaur, O and Turton, S and Nour, MM and Day, CM and Leech, R and Nutt, D and Carhart-Harris, R},
doi = {10.1101/706283},
publisher = {Cold Spring Harbor Laboratory},
title = {Neural correlates of the DMT experience as assessed via multivariate EEG},
url = {http://dx.doi.org/10.1101/706283},
year = {2019}
}
Download

RIS format (EndNote, RefMan)

TY  - UNPB
AB  - <jats:title>Abstract</jats:title><jats:p>Studying transitions in and out of the altered state of consciousness caused by intravenous (IV) N,N-Dimethyltryptamine (DMT – a fast-acting tryptamine psychedelic) offers a safe and powerful means of advancing knowledge on the neurobiology of conscious states. Here we sought to investigate the effects of IV DMT on the power spectrum and signal diversity of human brain activity (6 female, 7 male) recorded via multivariate EEG, and plot relationships between subjective experience, brain activity and drug plasma concentrations across time. Compared with placebo, DMT markedly reduced oscillatory power in the <jats:italic>alpha</jats:italic> and <jats:italic>beta</jats:italic> bands and robustly increased spontaneous signal diversity. Time-referenced analyses revealed close relationships between changes in various aspects of subjective experience and changes in brain activity. Importantly, the emergence of oscillatory activity within the delta and theta frequency bands was found to correlate with the peak of the experience, and particularly its eyes-closed visual component. These findings highlight marked changes in oscillatory activity and signal diversity with DMT that parallel broad and specific components of the relevant subjective experience and thus further our understanding of the neurobiological underpinnings of immersive states of consciousness.</jats:p>
AU  - Timmermann,C
AU  - Roseman,L
AU  - Schartner,M
AU  - Milliere,R
AU  - Williams,L
AU  - Erritzoe,D
AU  - Muthukumaraswamy,S
AU  - Ashton,M
AU  - Bendrioua,A
AU  - Kaur,O
AU  - Turton,S
AU  - Nour,MM
AU  - Day,CM
AU  - Leech,R
AU  - Nutt,D
AU  - Carhart-Harris,R
DO  - 10.1101/706283
PB  - Cold Spring Harbor Laboratory
PY  - 2019///
TI  - Neural correlates of the DMT experience as assessed via multivariate EEG
UR  - http://dx.doi.org/10.1101/706283
ER  -
Download