Imperial College London
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ProfessorChristoferToumazou

Faculty of Engineering, Department of Electrical and Electronic Engineering

Winston Wong Chair, Biomedical Circuits
 
 
 
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Contact

 

+44 (0)20 7594 6255c.toumazou

 
 
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Assistant

 

Mrs Gifty Osei-Ansah +44 (0)20 7594 6168

 
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Location

 

405Bessemer BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Reddy:2014:10.1089/dia.2014.0009,
author = {Reddy, M and Herrero, P and El, Sharkawy M and Pesl, P and Jugnee, N and Thomson, H and Pavitt, D and Toumazou, C and Johnston, D and Georgiou, P and Oliver, N},
doi = {10.1089/dia.2014.0009},
journal = {Diabetes Technology and Therapeutics},
pages = {550--557},
title = {Feasibility study of a bio-inspired artificial pancreas in adults with type 1 diabetes},
url = {http://dx.doi.org/10.1089/dia.2014.0009},
volume = {16},
year = {2014}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background: This study assesses proof of concept and safety of a novel bio-inspired artificial pancreas (BiAP) system in adults with type 1 diabetes during fasting, overnight, and postprandial conditions. In contrast to existing glucose controllers in artificial pancreas systems, the BiAP uses a control algorithm based on a mathematical model of β-cell physiology. The algorithm is implemented on a miniature silicon microchip within a portable hand-held device that interfaces the components of the artificial pancreas.Materials and Methods: In this nonrandomized open-label study each subject attended for a 6-h fasting study followed by a 13-h overnight and post-breakfast study on a separate occasion. During both study sessions the BiAP system was used, and microboluses of insulin were recommended every 5 min by the control algorithm according to subcutaneous sensor glucose levels. The primary outcome was percentage time spent in the glucose target range (3.9–10.0 mmol/L).Results: Twenty subjects (55% male; mean [SD] age, 44 [10] years; duration of diabetes, 22 [12] years; glycosylated hemoglobin, 7.4% [0.7%] [57 (7) mmol/mol]; body mass index, 25 [4] kg/m2) participated in the fasting study, and the median (interquartile range) percentage time in target range was 98.0% (90.8–100.0%). Seventeen of these subjects then participated in the overnight/postprandial study, where 70.7% (63.9–77.4%) of time was spent in the target range and, reassuringly, 0.0% (0.0–2.3%) of time was spent in hypoglycemia (<3.9 mmol/L).Conclusions: The BiAP achieves safe glycemic control during fasting, overnight, and postprandial conditions.
AU  - Reddy,M
AU  - Herrero,P
AU  - El,Sharkawy M
AU  - Pesl,P
AU  - Jugnee,N
AU  - Thomson,H
AU  - Pavitt,D
AU  - Toumazou,C
AU  - Johnston,D
AU  - Georgiou,P
AU  - Oliver,N
DO  - 10.1089/dia.2014.0009
EP  - 557
PY  - 2014///
SN  - 1520-9156
SP  - 550
TI  - Feasibility study of a bio-inspired artificial pancreas in adults with type 1 diabetes
T2  - Diabetes Technology and Therapeutics
UR  - http://dx.doi.org/10.1089/dia.2014.0009
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000341241500002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
VL  - 16
ER  -
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