Imperial College London
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Dr Carolin Vegvari

Faculty of Medicine, School of Public Health

Visiting Researcher
 
 
 
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c.vegvari CV

 
 
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Location

 

LG 36Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Werkman:2018:10.1371/journal.pntd.0006864,
author = {Werkman, M and Toor, J and Vegvari, C and Wright, JE and Truscott, JE and Asbjornsdottir, KH and Means, AR and Walson, JL and Anderson, RM},
doi = {10.1371/journal.pntd.0006864},
journal = {PLoS Neglected Tropical Diseases},
title = {Defining stopping criteria for ending randomized clinical trials that investigate the interruption of transmission of soil-transmitted helminths employing mass drug administration},
url = {http://dx.doi.org/10.1371/journal.pntd.0006864},
volume = {12},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The current World Health Organization strategy to address soil-transmitted helminth (STH) infections in children is based on morbidity control through routine deworming of school and pre-school aged children. However, given that transmission continues to occur as a result of persistent reservoirs of infection in untreated individuals (including adults) and in the environment, in many settings such a strategy will need to be continued for very extended periods of time, or until social, economic and environmental conditions result in interruption of transmission. As a result, there is currently much discussion surrounding the possibility of accelerating the interruption of transmission using alternative strategies of mass drug administration (MDA). However, the feasibility of achieving transmission interruption using MDA remains uncertain due to challenges in sustaining high MDA coverage levels across entire communities. The DeWorm3 trial, designed to test the feasibility of interrupting STH transmission, is currently ongoing. In DeWorm3, three years of high treatment coverage—indicated by mathematical models as necessary for breaking transmission—will be followed by two years of surveillance. Given the fast reinfection (bounce-back) rates of STH, a two year no treatment period is regarded as adequate to assess whether bounce-back or transmission interruption have occurred in a given location. In this study, we investigate if criteria to determine whether transmission interruption is unlikely can be defined at earlier timepoints. A stochastic, individual-based simulation model is employed to simulate core aspects of the DeWorm3 community-based cluster-randomized trial. This trial compares a control arm (annual treatment of children alone with MDA) with an intervention arm (community-wide biannual treatment with MDA). Simulations were run for each scenario for both Ascaris lumbricoides and hookworm (Necator americanus). A range of threshold prevalences meas
AU  - Werkman,M
AU  - Toor,J
AU  - Vegvari,C
AU  - Wright,JE
AU  - Truscott,JE
AU  - Asbjornsdottir,KH
AU  - Means,AR
AU  - Walson,JL
AU  - Anderson,RM
DO  - 10.1371/journal.pntd.0006864
PY  - 2018///
SN  - 1935-2727
TI  - Defining stopping criteria for ending randomized clinical trials that investigate the interruption of transmission of soil-transmitted helminths employing mass drug administration
T2  - PLoS Neglected Tropical Diseases
UR  - http://dx.doi.org/10.1371/journal.pntd.0006864
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000449318100057&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/65242
VL  - 12
ER  -
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