Imperial College London
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DrCarolynWebb

Faculty of Medicine, National Heart & Lung Institute

Research Fellow
 
 
 
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Contact

 

+44 (0)20 7351 8860c.webb Website

 
 
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Location

 

3013Chelsea WingRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Gaudino:2020:10.1016/j.athoracsur.2019.07.010,
author = {Gaudino, M and Benedetto, U and Fremes, SE and Hare, DL and Hayward, P and Moat, N and Moscarelli, M and Di, Franco A and Nasso, G and Peric, M and Petrovic, I and Collins, P and Webb, CM and Puskas, JD and Speziale, G and Yoo, KJ and Girardi, LN and Taggart, DP and RADIAL, Investigators},
doi = {10.1016/j.athoracsur.2019.07.010},
journal = {Annals of Thoracic Surgery},
pages = {688--694},
title = {Angiographic outcome of coronary artery bypass grafts: Radial Artery Database International Alliance},
url = {http://dx.doi.org/10.1016/j.athoracsur.2019.07.010},
volume = {109},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: We used a large patient-level dataset including six angiographic randomized trials (RCTs) on coronary artery bypass conduits to explore incidence and determinants of coronary graft failure. METHODS: Patient-level angiographic data of six RCTs comparing long-term outcomes of the radial artery and other conduits were joined. Primary outcome was graft occlusion at maximum follow-up. The analysis was divided as follows: 1) left anterior descending coronary (LAD) distribution, 2) non-LAD distribution (circumflex and right coronary artery). To identify predictors of graft occlusion, mixed model multivariable Cox regression including all baseline characteristics with stratification by individual trials was used. RESULTS: 1091 patients and 2281 grafts were included (921 left internal mammary arteries, 74 right internal mammary arteries, 710 radial artery and 576 saphenous veins; all left internal mammary arteries were used on the LAD, the other conduits were used on the non-LAD distribution; mean angiographic follow up: 65±29 months). Occlusion rate was 2.3%, 13.5%, 9.4%, 17.5% for the left internal mammary arteries, right internal mammary arteries, radial artery and saphenous veins, respectively. At multivariable analysis type of conduit used, age, female gender, left ventricular ejection fraction<50% and use of the Y graft were significantly associated with graft occlusion in the non-LAD distribution. CONCLUSIONS: Our analyses showed that failure of the left internal mammary arteries to LAD bypass is a very uncommon event. For the non-LAD distribution, the non-use of radial artery, age, female gender, left ventricular ejection fraction<50% and use of the Y graft configuration were significantly associated with mid-term graft failure.
AU  - Gaudino,M
AU  - Benedetto,U
AU  - Fremes,SE
AU  - Hare,DL
AU  - Hayward,P
AU  - Moat,N
AU  - Moscarelli,M
AU  - Di,Franco A
AU  - Nasso,G
AU  - Peric,M
AU  - Petrovic,I
AU  - Collins,P
AU  - Webb,CM
AU  - Puskas,JD
AU  - Speziale,G
AU  - Yoo,KJ
AU  - Girardi,LN
AU  - Taggart,DP
AU  - RADIAL,Investigators
DO  - 10.1016/j.athoracsur.2019.07.010
EP  - 694
PY  - 2020///
SN  - 0003-4975
SP  - 688
TI  - Angiographic outcome of coronary artery bypass grafts: Radial Artery Database International Alliance
T2  - Annals of Thoracic Surgery
UR  - http://dx.doi.org/10.1016/j.athoracsur.2019.07.010
UR  - https://www.ncbi.nlm.nih.gov/pubmed/31470012
UR  - https://www.sciencedirect.com/science/article/pii/S0003497519312263?via%3Dihub
UR  - http://hdl.handle.net/10044/1/73226
VL  - 109
ER  -
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