Imperial College London
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Professor Carlton A W Evans

Faculty of Medicine, Department of Infectious Disease

Professor of Global Health
 
 
 
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Contact

 

+44 (0)20 3313 3222carlton.evans Website

 
 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Lee:2020:10.1371/journal.pone.0231167,
author = {Lee, GO and Comina, G and Hernandez-Cordova, G and Naik, N and Gayoso, O and Ticona, E and Coronel, J and Evans, C and Zimic, M and Paz-Soldan, VA and Gilman, RH and Oberhelman, R},
doi = {10.1371/journal.pone.0231167},
journal = {PLoS One},
pages = {1--13},
title = {Cough dynamics in adults receiving tuberculosis treatment},
url = {http://dx.doi.org/10.1371/journal.pone.0231167},
volume = {15},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Cough is a characteristic symptom of tuberculosis, is the main cause of transmission,and is used to assess treatment response. We aimed to identify the best measure ofcough severity and characterize changes during initial tuberculosis therapy.We conducted a prospective cohort of recently diagnosed ambulatory adult patientswith pulmonary tuberculosis in two tertiary hospitals in Lima, Peru. Pre-treatment andfive times during the first two months of treatment, a vibrometer was used to capture 4-hour recordings of involuntary cough. A total of 358 recordings from 69 participantswere analyzed using a computer algorithm.Total time spent coughing (seconds per hour) was a better predictor of microbiologicindicators of disease severity and treatment response than the frequency of coughepisodes or cough power. Patients with prior tuberculosis tended to cough more thanpatients without prior tuberculosis, and patients with tuberculosis and diabetescoughed more than patients without diabetes co-morbidity. Cough characteristics weresimilar regardless of HIV co-infection and for drug-susceptible versus drug-resistanttuberculosis.Tuberculosis treatment response may be meaningfully assessed by objectivelymonitoring the time spent coughing. This measure demonstrated that cough wasincreased in patients with TB recurrence or co-morbid diabetes, but not because ofdrug resistance or HIV co-infection.
AU  - Lee,GO
AU  - Comina,G
AU  - Hernandez-Cordova,G
AU  - Naik,N
AU  - Gayoso,O
AU  - Ticona,E
AU  - Coronel,J
AU  - Evans,C
AU  - Zimic,M
AU  - Paz-Soldan,VA
AU  - Gilman,RH
AU  - Oberhelman,R
DO  - 10.1371/journal.pone.0231167
EP  - 13
PY  - 2020///
SN  - 1932-6203
SP  - 1
TI  - Cough dynamics in adults receiving tuberculosis treatment
T2  - PLoS One
UR  - http://dx.doi.org/10.1371/journal.pone.0231167
UR  - https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0231167
UR  - http://hdl.handle.net/10044/1/78954
VL  - 15
ER  -
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