Imperial College London
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DrCarolinaHerrera

Faculty of Medicine, Department of Infectious Disease

Honorary Senior Research Fellow
 
 
 
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Contact

 

carolina.herrera

 
 
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Location

 

460 (Shattock Group)Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Berry:2022:10.3390/pathogens11091033,
author = {Berry, N and Stein, M and Ferguson, D and Ham, C and Hall, J and Giles, E and Kempster, S and Adedeji, Y and Almond, N and Herrera, C},
doi = {10.3390/pathogens11091033},
journal = {Pathogens},
pages = {1--18},
title = {Mucosal responses to Zika Virus infection in cynomolgus macaques},
url = {http://dx.doi.org/10.3390/pathogens11091033},
volume = {11},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Zika virus (ZIKV) cases continue to be reported, and no vaccine or specific antiviral agent has been approved for the prevention or treatment of infection. Though ZIKV is primarily transmitted by mosquitos, cases of sexual transmission and prolonged viral RNA presence in semen have been reported. In this observational study, we report the mucosal responses to sub-cutaneous and mucosal ZIKV exposure in cynomolgus macaques during acute and late chronic infection. Subcutaneous challenge induced a decrease in the growth factor VEGF in colorectal and cervicovaginal tissues 100 days post-challenge, in contrast to the observed increase in these tissues following vaginal infection. This different pattern was not observed in the uterus, where VEGF was upregulated independently of the challenge route. Vaginal challenge induced a pro-inflammatory profile in all mucosal tissues during late chronic infection. Similar responses were already observed during acute infection in a vaginal tissue explant model of ex vivo challenge. Non-productive and productive infection 100 days post-in vivo vaginal challenge induced distinct proteomic profiles which were characterized by further VEGF increase and IL-10 decrease in non-infected animals. Ex vivo challenge of mucosal explants revealed tissue-specific modulation of cytokine levels during the acute phase of infection. Mucosal cytokine profiles could represent biosignatures of persistent ZIKV infection.
AU  - Berry,N
AU  - Stein,M
AU  - Ferguson,D
AU  - Ham,C
AU  - Hall,J
AU  - Giles,E
AU  - Kempster,S
AU  - Adedeji,Y
AU  - Almond,N
AU  - Herrera,C
DO  - 10.3390/pathogens11091033
EP  - 18
PY  - 2022///
SN  - 2076-0817
SP  - 1
TI  - Mucosal responses to Zika Virus infection in cynomolgus macaques
T2  - Pathogens
UR  - http://dx.doi.org/10.3390/pathogens11091033
UR  - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000856699100001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.mdpi.com/2076-0817/11/9/1033
UR  - http://hdl.handle.net/10044/1/100444
VL  - 11
ER  -
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