Imperial College London
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DrCarolinaHerrera

Faculty of Medicine, Department of Infectious Disease

Honorary Senior Research Fellow
 
 
 
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Contact

 

carolina.herrera

 
 
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Location

 

460 (Shattock Group)Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Herrera:2022:10.3389/frph.2022.998913,
author = {Herrera, C and Olejniczak, N and Noël-Romas, L and Plummer, F and Burgener, A},
doi = {10.3389/frph.2022.998913},
journal = {Frontiers in Reproductive Health},
title = {Pre-clinical evaluation of antiproteases as potential candidates for HIV-1 pre-exposure prophylaxis},
url = {http://dx.doi.org/10.3389/frph.2022.998913},
volume = {4},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Previous studies on highly HIV-1-exposed, yet persistently seronegative women from the Punwami Sex Worker cohort in Kenya, have shed light on putative protective mechanisms, suggesting that mucosal immunological factors, such as antiproteases, could be mediating resistance to HIV-1 transmission in the female reproductive tract. Nine protease inhibitors were selected for this study: serpin B4, serpin A1, serpin A3, serpin C1, cystatin A, cystatin B, serpin B13, serpin B1 and α-2-macroglobulin-like-protein 1. We assessed in a pilot study, the activity of these antiproteases with cellular assays and an ex vivo HIV-1 challenge model of human ecto-cervical tissue explants. Preliminary findings with both models, cellular and tissue explants, established an order of inhibitory potency for the mucosal proteins as candidates for pre-exposure prophylaxis when mimicking pre-coital use. Combination of all antiproteases considered in this study was more active than any of the individual mucosal proteins. Furthermore, the migration of cells out of ecto-cervical explants was blocked indicating potential prevention of viral dissemination following amplification of the founder population. These findings constitute the base for further development of these mucosal protease inhibitors for prevention strategies.
AU  - Herrera,C
AU  - Olejniczak,N
AU  - Noël-Romas,L
AU  - Plummer,F
AU  - Burgener,A
DO  - 10.3389/frph.2022.998913
PY  - 2022///
SN  - 2673-3153
TI  - Pre-clinical evaluation of antiproteases as potential candidates for HIV-1 pre-exposure prophylaxis
T2  - Frontiers in Reproductive Health
UR  - http://dx.doi.org/10.3389/frph.2022.998913
UR  - http://hdl.handle.net/10044/1/101426
VL  - 4
ER  -
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