Publications
42 results found
Sands CJ, Guha IN, Kyriakides M, et al., 2015, Metabolic phenotyping for enhanced mechanistic stratification of chronic Hepatitis C-Induced liver fibrosis, American Journal of Gastroenterology, Vol: 110, Pages: 159-169, ISSN: 0002-9270
Objectives: The invasive nature of biopsy alongside issues with categorical staging and sampling error has driven research into noninvasive biomarkers for the assessment of liver fibrosis in order to stratify and personalize treatment of patients with liver disease. Here, we sought to determine whether a metabonomic approach could be used to identify signatures reflective of the dynamic, pathological metabolic perturbations associated with fibrosis in chronic hepatitis C (CHC) patients.Methods: Plasma nuclear magnetic resonance (NMR) spectral profiles were generated for two independent cohorts of CHC patients and healthy controls (n=50 original andn=63 validation). Spectral data were analyzed and significant discriminant biomarkers associated with fibrosis (as graded by enhanced liver fibrosis (ELF) and METAVIR scores) identified using orthogonal projection to latent structures (O-PLS).Results: Increased severity of fibrosis was associated with higher tyrosine, phenylalanine, methionine, citrate and, very-low-density lipoprotein (vLDL) and lower creatine, low-density lipoprotein (LDL), phosphatidylcholine, and N-Acetyl-α1-acid-glycoprotein. Although area under the receiver operator characteristic curve analysis revealed a high predictive performance for classification based on METAVIR-derived models, <40% of identified biomarkers were validated in the second cohort. In the ELF-derived models, however, over 80% of the biomarkers were validated.Conclusions: Our findings suggest that modeling against a continuous ELF-derived score of fibrosis provides a more robust assessment of the metabolic changes associated with fibrosis than modeling against the categorical METAVIR score. Plasma metabolic phenotypes reflective of CHC-induced fibrosis primarily define alterations in amino-acid and lipid metabolism, and hence identify mechanistically relevant pathways for further investigation as therapeutic targets.
MacIntyre DA, Lee YS, Marchesi J, et al., 2014, Preterm Premature Rupture of Membranes (PPROM) Is Associated with Disparate Vaginal Microbiomes That Are Correlated with Specific Urinary Metabolic Profiles, 61st Annual Scientific Meeting of the Society-for-Gynecologic-Investigation (SGI), Publisher: SAGE PUBLICATIONS INC, Pages: 246A-246A, ISSN: 1933-7191
Alves AC, Li JV, Garcia-Perez I, et al., 2012, Characterization of data analysis methods for information recovery from metabolic 1H NMR spectra using artificial complex mixtures, Metabolomics, Vol: 8, Pages: 1170-1180
Li JV, Ashrafian H, Bueter M, et al., 2012, Metabolic surgery profoundly influences gut microbial-host metabolic cross-talk, Gut, Vol: 60, Pages: 1214-1223
Sands CJ, Coen M, Ebbels TMD, et al., 2011, Data-Driven Approach for Metabolite Relationship Recovery in Biological <SUP>1</SUP>H NMR Data Sets Using Iterative Statistical Total Correlation Spectroscopy, ANALYTICAL CHEMISTRY, Vol: 83, Pages: 2075-2082, ISSN: 0003-2700
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- Citations: 30
Sands CJ, Coen M, Ebbels TMD, et al., 2011, Data-Driven Approach for Metabolite Relationship Recovery in Biological 1H NMR Data Sets Using Iterative Statistical Total Correlation Spectroscopy, Analytical Chemistry, Vol: 83, Pages: 2075-2082
Sands CJ, Coen M, Maher AD, et al., 2009, Statistical Total Correlation Spectroscopy Editing of <SUP>1</SUP>H NMR Spectra of Biofluids: Application to Drug Metabolite Profile Identification and Enhanced Information Recovery, ANALYTICAL CHEMISTRY, Vol: 81, Pages: 6458-6466, ISSN: 0003-2700
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- Citations: 33
Sands CJ, Coen M, Maher AD, et al., 2009, Statistical Total Correlation Spectroscopy Editing of 1H NMR Spectra of Biofluids: Application to Drug Metabolite Profile Identification and Enhanced Information Recovery, Analytical Chemistry, Vol: 81, Pages: 6458-6466
MartinezArgudo I, Sands C, Jepson MA, 2007, Translocation of enteropathogenic Escherichia coli across an in vitro M cell model is regulated by its type III secretion system, Cellular Microbiology, Vol: 9, Pages: 1538-1546
Pye VE, Dreveny I, Briggs LC, et al., 2006, Going through the motions: The ATPase cycle of p97, JOURNAL OF STRUCTURAL BIOLOGY, Vol: 156, Pages: 12-28, ISSN: 1047-8477
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- Citations: 79
Pye VE, Dreveny I, Briggs LC, et al., 2006, Going through the motions: The ATPase cycle of p97, Journal of Structural Biology, Vol: 156, Pages: 12-28
Buda A, Sands C, Jepson MA, 2005, Use of fluorescence imaging to investigate the structure and function of intestinal M cells, Advanced Drug Delivery Reviews, Vol: 57, Pages: 123-134
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